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Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2010722117Source: DataRank Database

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation is a research paper published in Proceedings of the National Academy of Sciences (2020). On theSindex it has a DataRank of 0. It has been cited 361 times.

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Enrichment:Funding (4 grants)OA: hybridTopics (72)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, PMC)Annotations (3)SDGs (1)

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Authors (9)

She Zhang ORCID,Rebecca A. Porritt ORCID,Magali Noval Rivas ORCID,Lisa Paschold ORCID,Edith Willscher ORCID

Live enrichment

PubMed:32989130 PMC:PMC7568239

HHS | National Institutes of Health

Grant: P41 GM103712

HHS | National Institutes of Health

Grant: R01 AI072726

National Institutes of Health

Grant: 5P41GM103712-08

High Performance Computing for Multiscale Modeling of Biological Systems

National Institutes of Health

Grant: 5R01AI072726-07

Role of IL-1 in Bacterial ligand-induced vasculitis and myocarditis

hybridLicense: CC BY

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2010722117

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2010722117

Unpaywallhttps://escholarship.org/uc/item/8fk232rz

Europe_PMChttps://europepmc.org/articles/PMC7568239

Europe_PMChttps://europepmc.org/articles/PMC7568239?pdf=render

Fields of Study

0302 clinical medicine03 medical and health sciences

MeSH Terms

HumansPneumonia, ViralCoronavirus InfectionsIntercellular Adhesion Molecule-1Receptors, Antigen, T-CellEnterotoxinsNeurotoxinsEpitopes, T-LymphocyteSuperantigensAmino Acid MotifsProtein BindingMutationModels, MolecularSystemic Inflammatory Response SyndromePandemicsSpike Glycoprotein, CoronavirusBetacoronavirusCOVID-19SARS-CoV-2

Keywords

SuperantigenToxic Shock SyndromeCovid-19Sars-cov-2 SpikeTcr BindingModels, MolecularAmino Acid MotifsEpitopes, T-LymphocyteEpitopesEnterotoxinsModelsReceptors2.1 Biological and endogenous factorsViralAetiologyLungMultidisciplinarySuperantigensBiological SciencesIntercellular Adhesion Molecule-1Spike GlycoproteinSystemic Inflammatory Response SyndromeInfectious DiseasesMedical MicrobiologyAntigenPhysical SciencesSpike Glycoprotein, CoronavirusPneumonia & InfluenzaCoronavirus InfectionsProtein Binding570NeurotoxinsPneumonia, ViralReceptors, Antigen, T-Cell610Vaccine RelatedBetacoronavirusBiodefenseHumansPandemicsBiomedical and Clinical SciencesSARS-CoV-2PreventionInflammatory and immune systemMolecularPneumoniaT-CellCoronavirusEmerging Infectious DiseasesT-LymphocyteMutation

Sustainable Development Goals

SDG 3: 3. Good health

Additional file 7 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608322.v1figshare

Additional file 7 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

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Additional file 1 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608304.v1figshare

Additional file 1 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608304figshare

Additional file 2 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608307.v1figshare

Additional file 2 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608307figshare

Additional file 3 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608310.v1figshare

Additional file 3 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608310figshare

Additional file 4 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

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Additional file 4 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608313figshare

Additional file 6 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608319.v1figshare

Additional file 6 of Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children

10.6084/m9.figshare.22608319figshare

Additional file 1 of The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection

10.6084/m9.figshare.26664427figshare

Additional file 1 of The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection

10.6084/m9.figshare.26664427.v1figshare

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

FAIR Checklist

Authors (9)

Funding (4 grants)

Open Access

Topics

Linked Datasets (14)

Annotations (Europe PMC)