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SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2016650117Source: DataRank Database

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling is a research paper published in Proceedings of the National Academy of Sciences (2020). On theSindex it has a DataRank of 0.953. It has been cited 575 times.

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0.953DataRank · unranked

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Open Access575 citations

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Enrichment:Funding (9 grants)Impact (FWCI 10.87)OA: hybridTopics (58)Linked Datasets (25)DataCite Reuse (25)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.953

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Authors (27)

Thomas Kehrer ORCID,María Teresa Sánchez-Aparicio ORCID,Ke Zhang ORCID,Phillip Cohen ORCID,Roosheel S. Patel ORCID

Live enrichment

PubMed:33097660 PMC:PMC7668094 OpenAlex:https://openalex.org/W3094558943

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: HHSN272201400008C

Defense Sciences Office, DARPA

Grant: HR0011-19-20020

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R01AI154635

Gouvernement du Canada | Canadian Institutes of Health Research

Grant: 156030

HHS | NIH | National Institute of General Medical Sciences

Grant: 5R35GM133743

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: U19AI118610

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: U19AI135972

NIGMS NIH HHS

Grant: R35 GM133743

NIAID NIH HHS

Grant: U19 AI135990

FWCI

10.87

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1073/pnas.2016650117

publisherhttps://doi.org/10.1073/pnas.2016650117

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2016650117

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2016650117

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33097660

Fields of Study

SARS-CoV-2 and COVID-19 Researchinterferon and immune responsesAnimal Virus Infections StudiesActive Transport, Cell NucleusAnimalsBinding SitesCOVID-19Chlorocebus aethiopsHEK293 CellsHumansInterferonsNuclear Matrix-Associated ProteinsNuclear PoreNuclear Pore Complex ProteinsNucleocytoplasmic Transport ProteinsProtein BindingSTAT1 Transcription FactorSTAT2 Transcription FactorSignal TransductionVero CellsViral Proteins

MeSH Terms

COVID-19AnimalsBinding SitesChlorocebus aethiopsHumansInterferonsProtein BindingVero CellsViral ProteinsSignal TransductionActive Transport, Cell NucleusNuclear PoreNuclear Pore Complex ProteinsNucleocytoplasmic Transport ProteinsNuclear Matrix-Associated ProteinsSTAT1 Transcription FactorSTAT2 Transcription FactorHEK293 Cells

Keywords

InterferonSTAT1BiologystatSignal transductionCell biologyViral infectionVirologyNuclear transportImmune systemVirusImmunologyCell nucleusNucleusStatsNup98Orf6Sars-cov-2Interferon Signaling Antagonism

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment

10.6084/m9.figshare.14313949.v1figshare

Additional file 1 of Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment

10.6084/m9.figshare.14313949figshare

Additional file 1 of Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

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Additional file 1 of Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

10.6084/m9.figshare.14314289figshare

Additional file 1 of Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity

10.6084/m9.figshare.23722249.v1figshare

Additional file 1 of Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity

10.6084/m9.figshare.23722249figshare

Additional file 11 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077108.v1figshare

Additional file 10 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

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Additional file 11 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077108figshare

Additional file 10 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077105figshare

Additional file 7 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

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Additional file 7 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077096figshare

Additional file 8 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077099.v1figshare

Additional file 9 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077102.v1figshare

Additional file 9 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077102figshare

Additional file 8 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077099figshare

Additional file 6 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

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Additional file 4 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

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Additional file 5 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077090figshare

Additional file 3 of Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations

10.6084/m9.figshare.24077084figshare