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Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2215916120Source: DataRank Database

Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein is a research paper published in Proceedings of the National Academy of Sciences (2023). On theSindex it has a DataRank of 0. It has been cited 25 times.

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Open Access25 citations

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Data and code for: Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist and stimulatory G protein · Dryad

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (24 grants)Impact (FWCI 2.36)OA: hybridTopics (46)Linked Datasets (1)DataCite Reuse (1)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (9)

John R.D. Dawson ORCID,Kevin R. DeMarco ORCID,Kyle C. Rouen ORCID,Slava Bekker ORCID,Vladimir Yarov‐Yarovoy ORCID

Live enrichment

PubMed:36853938 PMC:PMC10013855 OpenAlex:https://openalex.org/W4322617999

HHS | NIH | NIH Office of the Director

Grant: OT2OD026580

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: R01HL128537

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: R01HL152681

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: U01HL126273

American Heart Association

Grant: 19CDA34770101

American Heart Association

Grant: 16PRE27260295

National Science Foundation

Grant: 2032486

Frontera Travel Grant: Enhanced Atomistic Simulations for Predictive Multi-Scale Modeling Safety Pharmacology Pipeline

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: R01HL162825

Center for Integrated Healthcare, U.S. Department of Veterans Affairs

Grant: 01BX005100

Center for Integrated Healthcare, U.S. Department of Veterans Affairs

Grant: IK6BX005753

BLRD VA

Grant: I01 BX005100

NHLBI NIH HHS

Grant: T32 HL086350

NIGMS NIH HHS

Grant: T32 GM136597

NIGMS NIH HHS

Grant: T32 GM099608

NIGMS NIH HHS

Grant: R01 GM116961

National Institutes of Health

Grant: 5R01HL162825-03

Regulation of a cardiac b1AR/SERCA2 complex in heart failure

National Institutes of Health

Grant: 5T32GM099608-04

Pharmacology Training: Bench to Bedside

National Institutes of Health

Grant: 5T32GM136597-02

UC Davis Chemical Biology Program

National Institutes of Health

Grant: 5R01GM116961-04

Breakthrough Molecular Dynamics Research via an Anton2 Supercomputer

National Institutes of Health

Grant: 5IK6BX005753-02

BLRD Research Career Scientist Award Application

National Institutes of Health

Grant: 5R01HL128537-02

In silico Safety Pharmacology

National Institutes of Health

Grant: 5R01HL152681-03

Multi-Scale Modeling of Vascular Signaling Units

National Institutes of Health

Grant: 5U01HL126273-04

Predictive multiscale in silico cardio-pharmacology

National Institutes of Health

Grant: 3OT2OD026580-01S4

Development of the Predictive NeuroCardiovascular Simulator

FWCI

2.36

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1073/pnas.2215916120

publisherhttps://doi.org/10.1073/pnas.2215916120

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2215916120

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36853938

repositoryhttps://escholarship.org/uc/item/07j4d27h

Fields of Study

Receptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyMass Spectrometry Techniques and Applications0301 basic medicine03 medical and health sciences

MeSH Terms

LigandsNorepinephrineSignal TransductionReceptors, Adrenergic, beta-2GTP-Binding Protein alpha Subunits, GsMolecular Dynamics Simulation

Keywords

G protein-coupled receptorChemistryG proteinReceptorAgonistBiophysicsAllosteric regulationSignal transductionLigand (biochemistry)Inverse agonistGs alpha subunitTransmembrane domainStereochemistryBiochemistryBiologyNorepinephrineMolecular dynamicsSympathetic nervous system5701.1 Normal biological development and functioningbeta-2Molecular Dynamics SimulationLigandsGsReceptorsGTP-Binding Protein alpha Subunits, GsNeurosciencesBiological Sciences540GTP-Binding Protein alpha SubunitsAdrenergicChemical SciencesBiochemistry and Cell BiologyGeneric health relevanceReceptors, Adrenergic, beta-2

Data and code for: Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist and stimulatory G protein

10.25338/b89h1tDryad