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LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2303789120Source: DataRank Database

LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition is a research paper published in Proceedings of the National Academy of Sciences (2023). On theSindex it has a DataRank of 0. It has been cited 75 times.

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Open Access75 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)OA: hybridTopics (21)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC)Annotations (2)

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Findable (2/2)

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Accessible (1/2)

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Interoperable (2/2)

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Authors (2)

Shawn M. Ferguson ORCID,Narayana Yadavalli ORCID

Live enrichment

PubMed:37487100 PMC:PMC10400961

Aligning Science Across Parkinson's

Grant: ASAP-000580

Impaired integration of organelle function in Parkinson’s disease

Ludwig Family Foundation

Grant: N/A

hybridLicense: cc-by

publisherhttps://doi.org/10.1073/pnas.2303789120

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2303789120

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10400961/pdf/pnas.202303789.pdf

Europe_PMChttps://europepmc.org/articles/PMC10400961

Europe_PMChttps://europepmc.org/articles/PMC10400961?pdf=render

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

MicrogliaLysosomesMacrophagesHumansParkinson DiseaseTranscription FactorsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2

Keywords

MacrophageLysosomeMicrogliaParkinson’s DiseaseMacrophagesHumansParkinson DiseaseBiological SciencesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LysosomesTranscription Factors

Additional file 1 of LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

10.6084/m9.figshare.25341205.v1figshare

Additional file 1 of LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

10.6084/m9.figshare.25341205figshare