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IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2404349121Source: DataRank Database

IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 25 times.

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Open Access25 citations

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Enrichment:Funding (4 grants)OA: hybridTopics (29)IDs (PubMed, PMC)Annotations (1)

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Authors (6)

Karthika Nagalekshmi ORCID,Sean Matthew McCauley ORCID,Claudia Carbone ORCID,Özkan Aydemir ORCID,Jeremy Luban ORCID

Live enrichment

PubMed:38985764 PMC:PMC11260138

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R37AI147868

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: U54AI170856

National Institutes of Health

Grant: 1U54AI170856-01

CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics

National Institutes of Health

Grant: 5R37AI147868-05

The HUSH complex in HIV-1 latency

hybridLicense: cc-by-nc-nd

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2404349121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2404349121

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11260138/pdf/pnas.202404349.pdf

Europe_PMChttps://europepmc.org/articles/PMC11260138

Europe_PMChttps://europepmc.org/articles/PMC11260138?pdf=render

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Dendritic CellsHumansProvirusesHIV-1HIV InfectionsAdaptor Proteins, Signal TransducingKaryopherinsRNA, ViralIntronsImmunity, InnateInterferon-Induced Helicase, IFIH1

Keywords

HIV-1Dendritic cellsMDA5Type 1 InterferonUnspliced RnaInterferon-Induced Helicase, IFIH1HIV InfectionsBiological SciencesKaryopherinsArticleImmunity, InnateIntronsProvirusesHumansRNA, ViralAdaptor Proteins, Signal Transducing