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RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling

Journal of Biological Chemistry(2020)10.1074/jbc.ra119.011080Source: DataRank Database

RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0.622. It has been cited 13 times, with 9 citing works in its 1-hop citation network.

N/A

0.622DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access13 citations · 9 citing works in its network

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pdb doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB6OB2 1HE8 4G0N 3CON 6MBT

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 0.52)OA: hybridTopics (74)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 64%Citation Network 36%

Base Score Contribution

0.396

From this paper's citation signal

Citation Network Contribution

0.226

From 8 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 9 citers.

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Q61 mutant-mediated dynamics changes of the GTP-KRAS complex probed by Gaussian accelerated molecular dynamics and free energy landscapes
RSC Advances202240 citations107 referencesContributes 0.035
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SAR and QSAR in environmental research202319 citations88 referencesContributes 0.034
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Computers in Biology and Medicine20242 citations34 referencesContributes 0.032

Authors (16)

Thomas J. Turbyville ORCID,Srisathiyanarayanan Dharmaiah ORCID,Megan Rigby ORCID,Rendong Yang ORCID,Ting-You Wang ORCID

Live enrichment

PubMed:32393580 PMC:PMC7363148 OpenAlex:https://openalex.org/W3023448647

American Cancer Society

Grant: 118198-IRG-58-001-52-IRG94

HHS | NIH | National Center for Advancing Translational Sciences

Grant: 8UL1TR000114

HHS | NIH | National Institute of General Medical Sciences

Grant: P30 GM124165

NCATS NIH HHS

Grant: UL1 TR000114

NIH HHS

Grant: S10 OD021527

CCR NIH HHS

Grant: HHSN261200800001C

NCI NIH HHS

Grant: HHSN261200800001E

National Institutes of Health

Grant: 3UL1TR000114-04S1

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)

National Institutes of Health

Grant: 1S10OD021527-01

Pixel Array Detector for Macromolecular Crystallography

National Institutes of Health

Grant: 3P30GM124165-03S1

NE-CAT: A Resource for Advanced Macromolecular Crystallography

FWCI

0.52

Citation Percentile

0.6%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1074/jbc.ra119.011080

publisherhttps://doi.org/10.1074/jbc.ra119.011080

publisherhttps://api.elsevier.com/content/article/PII:S0021925817489575?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817489575?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA119.011080

Fields of Study

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamicsPI3K/AKT/mTOR signaling in cancer0301 basic medicine0303 health sciences03 medical and health sciencesColorectal NeoplasmsCrystallography, X-RayGTP PhosphohydrolasesHEK293 CellsHumansMAP Kinase Signaling SystemMembrane ProteinsMutationProtein DomainsProto-Oncogene MasProto-Oncogene Proteins p21(ras)Exome Sequencingraf Kinases

MeSH Terms

Protein DomainsExome SequencingProto-Oncogene MasHumansMembrane ProteinsMutationColorectal NeoplasmsProto-Oncogene Proteins p21(ras)Crystallography, X-RayGTP PhosphohydrolasesMAP Kinase Signaling Systemraf KinasesHEK293 Cells

Keywords

Neuroblastoma RAS viral oncogene homologNeurofibromin 1KRASMAPK/ERK pathwayBiologyCancer researchGTPaseGTPase-activating proteinKinaseHRASCarcinogenesisOncogeneSignal transductionProtein kinase AMutationColorectal cancerCancerCell biologyGeneticsGeneG proteinCell cycleRas proteinColon cancerprotein structurePersonalized MedicineStructural BiologyTandem DuplicationExome SequencingBedside-to-bench AnalysisSwitch Ii DomainMAP Kinase Signaling SystemMembrane ProteinsCrystallography, X-RayProto-Oncogene MasGTP PhosphohydrolasesProto-Oncogene Proteins p21(ras)HEK293 CellsProtein DomainsHumansraf KinasesColorectal Neoplasms

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being