M.R. Sawaya

Also affiliated with UCLA Health, UCLA Medical Center, Abterra Biosciences (United States), Institute of Molecular Medicine, Genomics (United Kingdom)

Materials ScienceMedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 60 papers. Top paper: “The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure”.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1917914117

N/A

4.3DataRank · unranked

183 citations

Binsen Li, Chuanqi Sun, Weijia Fan, Kang Zhou, Michael P. Hughes +4 more

Structural basis for L-isoaspartyl-containing protein recognition by the human PCMTD1 cullin-RING E3 ubiquitin ligase

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110735

N/A

0.208DataRank · unranked

3 citations

Boyu Zhao, Cameron Flowers, Elizabeth Oroudjeva, J. K. Winter, Vijaya Pandey +6 more

Structural basis of heme scavenging by the ChtA and HtaA hemophores in Corynebacterium diphtheriae

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110633

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0.104DataRank · unranked

1 citations

Andrew K. Goring, Yuri Lee, Megan Chen, Brendan J. Mahoney, M.R. Sawaya +4 more

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

Nature Structural & Molecular Biology(2020)10.1038/s41594-020-0403-y

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0DataRank · unranked

98 citations

M.R. Sawaya, P. Ge, Marcus Gallagher-Jones, Connor Short, Ronquiajah Bowman +5 more

Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER

Acta Crystallographica Section D Structural Biology(2020)10.1107/s2059798320008049

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0DataRank · unranked

17 citations

Claudia Millán, Jennifer Miao, Michael W. Martynowycz, M.R. Sawaya, Tamir Gonen +4 more

Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization

Protein Science(2020)10.1002/pro.3941

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0DataRank · unranked

13 citations

Vy N. Nguyen, Mengxiao Nie, M.R. Sawaya, Thomas A. Bobik, Todd O. Yeates +1 more

Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade

Nature Communications(2020)10.1038/s41467-020-14894-w

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0DataRank · unranked

39 citations

Anne‐Sophie Banneville, Elena A. Andreeva, Aaron S. Brewster, Mark S. Hunter, Raymond G. Sierra +33 more

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.013638

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0DataRank · unranked

36 citations

Paul M. Seidler, M.R. Sawaya, Duilio Cascio, Tianxiao Yang, Stephan Philipp +11 more

Computational design of mixed chirality peptide macrocycles with internal symmetry

Protein Science(2020)10.1002/pro.3974

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0DataRank · unranked

36 citations

Christine S. Kang, M.R. Sawaya, Stephen Rettie, Xinting Li, I. Antselovich +7 more

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.25.114967

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0DataRank · unranked

3 citations

David R. Boyer, M.R. Sawaya, P. Ge, David Eisenberg, Qin Cao

The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.24.113621

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0DataRank · unranked

1 citations

Qin Cao, Michael P. Hughes, M.R. Sawaya, David R. Boyer, Duilio Cascio +2 more

The expanding amyloid family: Structure, stability, function, and pathogenesis

Cell(2021)10.1016/j.cell.2021.08.013

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0DataRank · unranked

479 citations

Michael P. Hughes, José A. Rodríguez, Roland Riek, David Eisenberg, M.R. Sawaya

Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores

Nature Structural & Molecular Biology(2021)10.1038/s41594-021-00646-x

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0DataRank · unranked

90 citations

David R. Boyer, M.R. Sawaya, Romany Abskharon, Lorena Saelices, Binh A. Nguyen +5 more

Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices

Protein Science(2021)10.1002/pro.4268

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0DataRank · unranked

15 citations

M.R. Sawaya, Debalina Acharyya, Jinchao Lou, Emery M. Edington, Michael D. Best +4 more

Structural characterization of hexameric shell proteins from two types of choline-utilization bacterial microcompartments

Acta Crystallographica Section F Structural Biology Communications(2021)10.1107/s2053230x21007470

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0DataRank · unranked

6 citations

Oscar Mijares, Andrea Acosta, Xavier Escoto, Nancy Leon-Rivera, Joanna D. Marshall +3 more

Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.05.434000

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0DataRank · unranked

24 citations

Xinyi Cheng, Christen E. Tai, Jeannette T. Bowler, Sarah L. Griner, M.R. Sawaya +19 more

Fragment-based ab initio phasing of peptidic nanocrystals by MicroED

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.13.459692

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0DataRank · unranked

3 citations

Maria D. Flores, Claudia Millán, Calina Glynn, Chih-Te Zee, M.R. Sawaya +5 more

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

Nature Communications(2022)10.1038/s41467-022-32951-4

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0DataRank · unranked

187 citations

Kevin A. Murray, David R. Boyer, P. Ge, M.R. Sawaya, Carolyn J. Hu +9 more

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43

Nature(2022)10.1038/s41586-022-04670-9

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0DataRank · unranked

180 citations

Qin Cao, M.R. Sawaya, Romany Abskharon, P. Ge, Michael DeTure +6 more

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2119952119

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0DataRank · unranked

98 citations

M.R. Sawaya, David R. Boyer, Qin Cao, Binh A. Nguyen, Duilio Cascio +2 more

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00774-y

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0DataRank · unranked

43 citations

Michael P. Hughes, Carolyn J. Hu, M.R. Sawaya, Łukasz Salwiński, Hope Pan +4 more

Extended β-Strands Contribute to Reversible Amyloid Formation

ACS Nano(2022)10.1021/acsnano.1c08043

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0DataRank · unranked

30 citations

Declan Evans, Michael P. Hughes, M.R. Sawaya, Carolyn J. Hu, K. N. Houk +2 more

De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

Nature Communications(2022)10.1038/s41467-022-31746-x

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0DataRank · unranked

27 citations

M.R. Sawaya, Elke De Zitter, Elena A. Andreeva, Anne‐Sophie Banneville, Natalie A. Schibrowsky +58 more

The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey

Chemical Science(2022)10.1039/d2sc02531k

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0DataRank · unranked

16 citations

M.R. Sawaya, Niko Vlahakis, Timothy C. Johnstone, David R. Boyer, José A. Rodríguez +3 more

Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102111

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0DataRank · unranked

7 citations

Jeffrey M. Vinokur, Kento Motoyama, Rino Ishikawa, Michael Collazo, Duilio Cascio +5 more

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.28.478258

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0DataRank · unranked

11 citations

M.R. Sawaya, David R. Boyer, Qin Cao, Binh A. Nguyen, Duilio Cascio +2 more

Structural polymorphism of amyloid fibrils in cardiac transthyretin amyloidosis revealed by cryo-electron microscopy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.21.496949

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0DataRank · unranked

8 citations

Shumaila Afrin, Virender Singh, Yasmin Ahmed, Rose Pedretti, María del Carmen Fernández‐Ramírez +12 more

Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.07.519389

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0DataRank · unranked

8 citations

M.R. Sawaya, David R. Boyer, Samantha Zink, Susanna Tovmasyan, Adrian Saucedo +5 more

Rigidified Scaffolds for 3 Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.18.508009

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0DataRank · unranked

6 citations

Kyle Meador, Mark A. Arbing, M.R. Sawaya, Morgan Gee, Duilio Cascio +6 more

Amyloid fibrils in frontotemporal lobar degeneration with TDP-43 inclusions are composed of TMEM106B, rather than TDP-43

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.31.478523

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0DataRank · unranked

1 citations

Qin Cao, M.R. Sawaya, Romany Abskharon, P. Ge, Michael DeTure +6 more

Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.11.483992

N/A

0DataRank · unranked

0 citations

Kang Zhou, Peter DePaola, Woo Shik Shin, Trae Hillyer, M.R. Sawaya +3 more

Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2305494120

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0DataRank · unranked

49 citations

Kyle Meador, Mark A. Arbing, M.R. Sawaya, Morgan Gee, Duilio Cascio +11 more

Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104566

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0DataRank · unranked

47 citations

Kang Zhou, Peter DePaola, Woo Shik Shin, Trae Hillyer, M.R. Sawaya +5 more

Racemic Peptides from Amyloid β and Amylin Form Rippled β-Sheets Rather Than Pleated β-Sheets

Journal of the American Chemical Society(2023)10.1021/jacs.3c11712

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0DataRank · unranked

16 citations

M.R. Sawaya, Maria Sajimon, Niko Vlahakis, José A. Rodríguez, David Eisenberg +2 more

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

Nature Communications(2023)10.1038/s41467-023-37865-3

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0DataRank · unranked

27 citations

Jeannette T. Bowler, Christen E. Tai, M.R. Sawaya, Yi Xiao Jiang, Gustavo Garcia +23 more

Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED

ACS Bio & Med Chem Au(2023)10.1021/acsbiomedchemau.2c00082

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0DataRank · unranked

10 citations

Maria D. Flores, Claudia Millán, Calina Glynn, Chih-Te Zee, M.R. Sawaya +5 more

Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core

Structure(2023)10.1016/j.str.2023.08.007

N/A

0DataRank · unranked

6 citations

Maria D. Flores, Samantha Zink, Natalie A. Schibrowsky, M.R. Sawaya, José A. Rodríguez +1 more

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105531

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0DataRank · unranked

5 citations

P. Ge, M.R. Sawaya, Michael P. Hughes, David R. Boyer, Qin Cao +5 more

Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method

PNAS Nexus(2023)10.1093/pnasnexus/pgad402

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0DataRank · unranked

4 citations

Romany Abskharon, David R. Boyer, P. Ge, M.R. Sawaya, David Eisenberg +1 more

DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.06.531355

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0DataRank · unranked

8 citations

Elizaveta Ustyantseva, David R. Boyer, Aydé Mendoza‐Oliva, Mikołaj I. Kuska, Paweł M. Wydorski +7 more

A Suite of Designed Protein Cages Using Machine Learning Algorithms and Protein Fragment-Based Protocols

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.09.561468

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0DataRank · unranked

3 citations

Roger Castells‐Graells, Roman Aguirre, M.R. Sawaya, Mark A. Arbing, Trent Sherman +3 more

Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.08.527771

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0DataRank · unranked

1 citations

Maria D. Flores, Samantha Zink, Natalie A. Schibrowsky, M.R. Sawaya, José A. Rodríguez +1 more

Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

Nature Communications(2024)10.1038/s41467-024-44820-3

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0DataRank · unranked

62 citations

Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed +13 more

A suite of designed protein cages using machine learning and protein fragment-based protocols

Structure(2024)10.1016/j.str.2024.02.017

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0DataRank · unranked

21 citations

Roger Castells‐Graells, Roman Aguirre, M.R. Sawaya, Mark A. Arbing, Trent Sherman +3 more

DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity

Structure(2024)10.1016/j.str.2024.02.015

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0DataRank · unranked

17 citations

Elizaveta Ustyantseva, David R. Boyer, Aydé Mendoza‐Oliva, Mikołaj I. Kuska, Paweł M. Wydorski +7 more

AlphaFold -assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography

Acta Crystallographica Section D Structural Biology(2024)10.1107/s205979832400072x

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0DataRank · unranked

8 citations

Matthew P. Agdanowski, Joshua L. Dolinsky, M.R. Sawaya, Duilio Cascio, José A. Rodríguez +2 more

How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer’s disease brain by a strain-relief mechanism

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.25.586668

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0DataRank · unranked

3 citations

P. Ge, M.R. Sawaya, Joshua L. Dolinsky, Yuan Yang, Yi Xiao Jiang +11 more

How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer’s disease brain by a strain-relief mechanism

Research Square(2024)10.21203/rs.3.rs-4152095/v1

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0DataRank · unranked

3 citations

Ke Hou, P. Ge, M.R. Sawaya, Joshua L. Dolinsky, Yuan Yang +11 more

X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation

Acta Crystallographica Section F Structural Biology Communications(2024)10.1107/s2053230x2400414x

N/A

0DataRank · unranked

0 citations

Roger Castells‐Graells, M.R. Sawaya, Duilio Cascio, Todd O. Yeates, Mark A. Arbing +1 more

How short peptides disassemble tau fibrils in Alzheimer’s disease

Nature(2025)10.1038/s41586-025-09244-z

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0DataRank · unranked

17 citations

P. Ge, M.R. Sawaya, Liisa Lutter, Joshua L. Dolinsky, Yuan Yang +12 more

Formation of rippled β-sheets from mixed chirality linear and cyclic peptides—new structural motifs based on the pauling-corey rippled β-sheet

Chemical Science(2025)10.1039/d4sc08079c

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0DataRank · unranked

8 citations

M.R. Sawaya, Hyeonju Lee, Maria Sajimon, Hyungjun Kim, William A. Goddard +3 more

Combining MicroED and native mass spectrometry for structural discovery of enzyme–small molecule complexes

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2503780122

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0DataRank · unranked

4 citations

Cameron W. Flowers, Mengting Liu, Matthew P. Agdanowski, Samuel Johnson, J. Summers +16 more

In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex

Cell Reports(2025)10.1016/j.celrep.2025.115971

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0DataRank · unranked

3 citations

M.R. Sawaya, Jonna B. Westover, Chenyi Wang, Frederick Jimenez, A. Muñoz +6 more

Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein

npj Parkinson s Disease(2025)10.1038/s41531-025-00918-z

N/A

0DataRank · unranked

2 citations

Melinda Balbirnie, Ke Hou, Naomi S. Sta Maria, Shruti Sahay, Paul Denver +20 more

Structural insights into functional regulation of the human CPEB3 prion by an amyloid-forming segment

Structure(2025)10.1016/j.str.2025.05.007

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0DataRank · unranked

2 citations

M.R. Sawaya, David R. Boyer, Samantha Zink, Susanna Tovmasyan, Adrian Saucedo +6 more

Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.21.654933

N/A

0DataRank · unranked

1 citations

Boyu Zhao, Cameron Flowers, Elizabeth Oroudjeva, J. K. Winter, Vijaya Pandey +6 more

Leveraging structure-informed machine learning for fast steric zipper propensity prediction across whole proteomes

PLoS Computational Biology(2025)10.1371/journal.pcbi.1013395

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0DataRank · unranked

0 citations

Songrong Qu, Thomas Holton, E. Bharani Shankar, P. G. Stanley, David Eisenberg +3 more

Leveraging bioorthogonal conjugation for alpha synuclein fibril surveillance

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.12.675751

N/A

0DataRank · unranked

0 citations

Shuang Wu, Gretchen Fujimura, A Lopez Heredia, Cameron W. Flowers, Chuanqi Sun +4 more

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

Nature Structural & Molecular Biology(2020)10.1038/s41594-020-0435-3

N/A

0DataRank · unranked

149 citations

David R. Boyer, M.R. Sawaya, P. Ge, David Eisenberg, Qin Cao

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

Nature Communications(2020)10.1038/s41467-020-17905-y

N/A

0DataRank · unranked

116 citations

Qin Cao, Michael P. Hughes, M.R. Sawaya, David R. Boyer, Duilio Cascio +2 more