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Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.015444Source: DataRank Database

Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 1.1. It has been cited 29 times, with 24 citing works in its 1-hop citation network.

N/A

1.1DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access29 citations · 24 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB1URN 6CMN 6MCE 5DEA 4AL5 6MCF

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 2.01)OA: hybridTopics (61)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 47%Citation Network 53%

Base Score Contribution

0.510

From this paper's citation signal

Citation Network Contribution

0.574

From 21 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 24 citers.

Statistical and thermodynamic analysis of the binding of trans-activation response–binding proteins to HIV-1 TAR RNA
Journal of Biological Chemistry20212 citations5 referencesContributes 0.220
Targeting Ribosomal Frameshifting as an Antiviral Strategy: From HIV-1 to SARS-CoV-2
Accounts of Chemical Research202125 citations64 referencesContributes 0.051
Inferring phase transitions and critical exponents from limited observations with thermodynamic maps
Proceedings of the National Academy of Sciences202424 citations72 referencesContributes 0.045
Conformational dynamics and energetics of viral RNA recognition by lab-evolved proteins
Physical Chemistry Chemical Physics202110 citations59 referencesContributes 0.041
Role of Mutations in Differential Recognition of Viral RNA Molecules by Peptides
Journal of Chemical Information and Modeling20227 citations56 referencesContributes 0.037

Authors (5)

Sachitanand M. Mali ORCID,Jermaine L. Jenkins ORCID,Rudi Fasan ORCID,Joseph E. Wedekind ORCID,Sai Shashank Chavali ORCID

Live enrichment

PubMed:33051202 OpenAlex:https://openalex.org/W3092492541

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R01 AI150463

NIGMS NIH HHS

Grant: P41 GM103393

NIGMS NIH HHS

Grant: R01 GM134076

NIH HHS

Grant: S10 OD030302

FWCI

2.01

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

hybridLicense: cc-by

journalhttps://doi.org/10.1074/jbc.ra120.015444

publisherhttps://doi.org/10.1074/jbc.ra120.015444

publisherhttps://api.elsevier.com/content/article/PII:S0021925817504688?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817504688?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA120.015444

Fields of Study

HIV Research and TreatmentRNA and protein synthesis mechanismsRNA Research and SplicingAmino Acid SequenceArginineCrystallography, X-RayDrug DesignHIV Long Terminal RepeatHIV-1HumansKineticsMolecular Dynamics SimulationMutagenesis, Site-DirectedNucleic Acid ConformationPeptides, CyclicProtein BindingRNA, ViralTATA-Box Binding ProteinThermodynamics

MeSH Terms

Amino Acid SequenceArginineHumansKineticsNucleic Acid ConformationPeptides, CyclicProtein BindingRNA, ViralThermodynamicsDrug DesignHIV-1Mutagenesis, Site-DirectedHIV Long Terminal RepeatCrystallography, X-RayTATA-Box Binding ProteinMolecular Dynamics Simulation

Keywords

RNAPeptideTranscription (linguistics)Cyclic peptideChemistryBiochemistryBinding selectivityBiologyStereochemistryGeneHIV TARHIV TatRNA structureRNA-binding proteinRNA-protein interactionRNA-protein interactionsX-ray crystallographyarginine-rich domaincyclic peptide inhibitordrug discoveryhuman immunodeficiency virus (HIV)isothermal titration calorimetryisothermal titration calorimetry (ITC)peptide chemical synthesissurface plasmon resonancesurface plasmon resonance (SPR)

Sustainable Development Goals

SDG 0: Responsible consumption and production