Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.016855Source: DataRank Database

Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 18 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access18 citations

Download PDF

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)OA: hybridTopics (50)IDs (PubMed, PMC)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (3)

Kevin D. McCarty ORCID,Jesse G. Chapman ORCID,F. Peter Guengerich ORCID

Live enrichment

PubMed:33449875 PMC:PMC7948456

National Institutes of Health

Grant: R01 GM118122

NIH HHS

Grant: S10 OD023514

National Institutes of Health

Grant: 5R01GM118122-21

Metabolism of Carcinogens and Drugs by Human P450s

hybridLicense: cc-by

publisherhttps://doi.org/10.1074/jbc.ra120.016855

publisherhttps://api.elsevier.com/content/article/PII:S0021925820003385?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925820003385?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA120.016855

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7948456

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsHumansRatsEscherichia coliItraconazoleClotrimazoleKetoconazoleIndinavirRitonavirHydroxyquinolinesSteroid HydroxylasesRecombinant ProteinsCloning, MolecularGene ExpressionKineticsGenetic VectorsCytochrome P-450 CYP3ABiocatalysisEnzyme AssaysCytochrome P-450 CYP3A Inhibitors

Keywords

Enzyme kineticsenzyme inhibitorCytochrome p450Enzyme MechanismUv–visible SpectroscopyPre–steady-state KineticsRitonavirGenetic VectorsGene ExpressionIndinavirRecombinant ProteinsRatsKineticsKetoconazoleSteroid HydroxylasesBiocatalysisEscherichia coliHydroxyquinolinesAnimalsCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsHumansCloning, MolecularClotrimazoleItraconazoleResearch ArticleEnzyme Assays

Sustainable Development Goals

SDG 3: 3. Good health