F. Peter Guengerich

Pharmacology, Toxicology and PharmaceuticsMedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 46 papers. Top paper: “A requirement for an active proton delivery network supports a compound I-mediated C–C bond cleavage in CYP51 catalysis”.

A requirement for an active proton delivery network supports a compound I-mediated C–C bond cleavage in CYP51 catalysis

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.014064

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1.1DataRank · unranked

38 citations

Z. Wawrzak, F. Peter Guengerich, Galina I. Lepesheva, Tatiana Y. Hargrove

Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update

Archives of Toxicology(2021)10.1007/s00204-020-02971-4

N/A

0.665DataRank · unranked

83 citations

F. Peter Guengerich, Slobodan Rendić

Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104841

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0.464DataRank · unranked

21 citations

Molly E. Sullivan, Yasuhiro Tateishi, Tatiana Y. Hargrove, Galina I. Lepesheva, F. Peter Guengerich +1 more

Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100969

N/A

0.406DataRank · unranked

14 citations

Kevin D. McCarty, Jesse G. Chapman, Yasuhiro Tateishi, F. Peter Guengerich

Cytochrome P450BM-3 and P450 11A1 retain Compound I (FeO3+) chemistry with electrophilic substrates poised for Compound 0 (Fe3+O2−) reactions

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110378

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0.241DataRank · unranked

4 citations

Yasuhiro Tateishi, F. Peter Guengerich, Kevin D. McCarty

A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1

Nature Communications(2025)10.1038/s41467-025-66558-2

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0.241DataRank · unranked

4 citations

Yoon-Mi Chung, Mohammad Alyamani, Yijing Dai, Kevin D. McCarty, Evan Roberts +13 more

Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100571

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0DataRank · unranked

29 citations

Vitchan Kim, Kevin D. McCarty, F. Peter Guengerich, Donghak Kim

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants

Drug Metabolism and Pharmacokinetics(2021)10.1016/j.dmpk.2021.100384

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0DataRank · unranked

21 citations

Takeshi Akiyoshi, Go Kawamura, Ayuko Imaoka, Mitsue Miyazaki, F. Peter Guengerich +4 more

Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101142

N/A

0DataRank · unranked

15 citations

F. Peter Guengerich, Sarah M. Glass

Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin

Archives of Biochemistry and Biophysics(2021)10.1016/j.abb.2021.109076

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0DataRank · unranked

12 citations

Stephany N. Webb, F. Peter Guengerich, Sarah M. Glass

Enzymatic bypass of an N6-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100444

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0DataRank · unranked

15 citations

Gabriela Gonzalez-Vasquez, Hui Wang, Kevin M. Johnson, Carl A. Sedgeman, F. Peter Guengerich +1 more

Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides

Genes and Environment(2021)10.1186/s41021-021-00199-x

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0DataRank · unranked

14 citations

Pratibha P. Ghodke, F. Peter Guengerich

Cytochrome b5 Binds Tightly to Several Human Cytochrome P450 Enzymes

Drug Metabolism and Disposition(2021)10.1124/dmd.121.000475

N/A

0DataRank · unranked

7 citations

Vitchan Kim, Yasuhiro Tateishi, F. Peter Guengerich, Donghak Kim

DNA polymerases η and κ bypass N2-guanine-O6-alkylguanine DNA alkyltransferase cross-linked DNA-peptides

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101124

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0DataRank · unranked

7 citations

F. Peter Guengerich, Pratibha P. Ghodke

Correction to Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1

Chemical Research in Toxicology(2021)10.1021/acs.chemrestox.0c00538

N/A

0DataRank · unranked

0 citations

Hyun D. Song, Clayton J. Wilkey, Jere P. Segrest, F. Peter Guengerich, Matthew E. Albertolle

1, N 6 ‐Ethenoadenosine, a Damaged Ribonucleotide in DNA: Impact on Translesion Synthesis and Repair

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.01596

N/A

0DataRank · unranked

0 citations

F. Peter Guengerich, Pratibha P. Ghodke

Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future

Advances in pharmacology(2022)10.1016/bs.apha.2021.12.001

N/A

0DataRank · unranked

40 citations

F. Peter Guengerich

Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13

Xenobiotica(2022)10.1080/00498254.2022.2062486

N/A

0DataRank · unranked

5 citations

Haruna Nagayoshi, Norie Murayama, Atsuki Sawai, Vitchan Kim, Donghak Kim +4 more

Cytochrome P450 Enzymes as Drug Targets in Human Disease

Drug Metabolism and Disposition(2023)10.1124/dmd.123.001431

N/A

0DataRank · unranked

23 citations

F. Peter Guengerich

The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105495

N/A

0DataRank · unranked

19 citations

Lu Liu, Yasuhiro Tateishi, Hannah L. Wapshott‐Stehli, F. Peter Guengerich, Kevin D. McCarty

Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1

Chemical Research in Toxicology(2023)10.1021/acs.chemrestox.3c00229

N/A

0DataRank · unranked

10 citations

Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki +3 more

Effects of 7-ketocholesterol on tamoxifen efficacy in breast carcinoma cell line models in vitro

The Journal of Steroid Biochemistry and Molecular Biology(2023)10.1016/j.jsbmb.2023.106354

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0DataRank · unranked

7 citations

Marie Ehrlichová, Shouzou Wei, F. Peter Guengerich, Pavel Souček, Alžběta Spálenková

3,4-Desaturation of retinoic acid by cytochrome P450 27C1 prevents P450-mediated catabolism

Archives of Biochemistry and Biophysics(2023)10.1016/j.abb.2023.109669

N/A

0DataRank · unranked

9 citations

Yasuhiro Tateishi, F. Peter Guengerich, Hong-Jaan Wang, Sarah M. Glass

Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1)

Methods in enzymology on CD-ROM/Methods in enzymology(2023)10.1016/bs.mie.2023.04.001

N/A

0DataRank · unranked

8 citations

Kevin D. McCarty, Yasuhiro Tateishi, Lu Liu, F. Peter Guengerich

Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases

Nucleic Acids Research(2023)10.1093/nar/gkad190

N/A

0DataRank · unranked

7 citations

Kevin D. McCarty, Jo Ann W. Byl, F. Peter Guengerich, Keir C. Neuman, Neil Osheroff +1 more

A history of the roles of cytochrome P450 enzymes in the toxicity of drugs

Toxicological Research(2020)10.1007/s43188-020-00056-z

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0DataRank · unranked

138 citations

F. Peter Guengerich

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro

Xenobiotica(2023)10.1080/00498254.2023.2248498

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0DataRank · unranked

1 citations

Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji +8 more

Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism

Pharmacological Reviews(2024)10.1124/pharmrev.124.001173

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0DataRank · unranked

53 citations

F. Peter Guengerich

Oxygen‐18 Labeling Reveals a Mixed Fe−O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α‐Demethylation

Angewandte Chemie International Edition(2024)10.1002/anie.202317711

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0DataRank · unranked

24 citations

Yasuhiro Tateishi, Tatiana Y. Hargrove, Galina I. Lepesheva, F. Peter Guengerich, Kevin D. McCarty

Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4

ACS Catalysis(2024)10.1021/acscatal.4c00106

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0DataRank · unranked

16 citations

Kevin D. McCarty, Martha V. Martin, F. Peter Guengerich, Yasuhiro Tateishi

Roles of Ferric Peroxide Anion Intermediates (Fe3+O2−, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model

Angewandte Chemie International Edition(2024)10.1002/anie.202406542

N/A

0DataRank · unranked

16 citations

Kevin D. McCarty, Martha V. Martin, Francis K. Yoshimoto, F. Peter Guengerich, Yasuhiro Tateishi

Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes

Archives of Toxicology(2024)10.1007/s00204-024-03710-9

N/A

0DataRank · unranked

15 citations

F. Peter Guengerich, Slobodan Rendić

Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations

International Journal of Molecular Sciences(2024)10.3390/ijms25169020

N/A

0DataRank · unranked

13 citations

Yasuhiro Tateishi, Kevin D. McCarty, Francis K. Yoshimoto, F. Peter Guengerich

Proteomics, modeling, and fluorescence assays delineate cytochrome b5 residues involved in binding and stimulation of cytochrome P450 17A1 17,20-lyase

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.105688

N/A

0DataRank · unranked

6 citations

Stephany N. Webb, Bian Li, Lu Liu, Kristie L. Rose, Micheal Leser +3 more

Roles of Ferric Peroxide Anion Intermediates (Fe3+O2−, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model

Angewandte Chemie(2024)10.1002/ange.202406542

N/A

0DataRank · unranked

1 citations

Kevin D. McCarty, Martha V. Martin, Francis K. Yoshimoto, F. Peter Guengerich, Yasuhiro Tateishi

Ninety-eight semesters of cytochrome P450 enzymes and related topics—What have I taught and learned?

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.105625

N/A

0DataRank · unranked

0 citations

F. Peter Guengerich

Liver fatty acid binding protein FABP1 transfers substrates to cytochrome P450 4A11 for catalysis

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108168

N/A

0DataRank · unranked

6 citations

F. Peter Guengerich, Kevin D. McCarty

Mass Spectral Analysis of Sterols and Other Steroids in Different Ionization Modes: Sensitivity and Oxidation Artifacts

Journal of the American Society for Mass Spectrometry(2025)10.1021/jasms.5c00099

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0DataRank · unranked

3 citations

F. Peter Guengerich, Kevin D. McCarty

A synthesis of 1β-hydroxytestosterone, a metabolite of xenobiotic human cytochrome P450 enzymes, beginning with a borylation of boldione

Organic & Biomolecular Chemistry(2025)10.1039/d5ob01218j

N/A

0DataRank · unranked

1 citations

Kevin D. McCarty, Hadi D. Arman, F. Peter Guengerich, Francis K. Yoshimoto, Anna I. Elizondo

Four germline POLH variants, including two found in skin tumors, impair DNA polymerase η function and cellular tolerance to UV radiation and cisplatin

Chemico-Biological Interactions(2025)10.1016/j.cbi.2025.111551

N/A

0DataRank · unranked

0 citations

Mina Yeom, Hye-Yeon Hwang, Eunji Mun, Jae-Hyeon Woo, Yeho Kim +6 more

Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells

International Journal of Molecular Sciences(2023)10.3390/ijms24065198

N/A

0DataRank · unranked

4 citations

Jin‐Kyung Hong, Joo‐Ho Shin, Yunjong Lee, F. Peter Guengerich, Jeong‐Yun Choi +1 more

Cytochrome P450 2E1 and its roles in disease

Chemico-Biological Interactions(2020)10.1016/j.cbi.2020.109056

N/A

0DataRank · unranked

114 citations

F. Peter Guengerich

Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.016855

N/A

0DataRank · unranked

18 citations

Kevin D. McCarty, Jesse G. Chapman, F. Peter Guengerich

Characterization of human adrenal cytochrome P450 11B2 products of progesterone and androstenedione oxidation

The Journal of Steroid Biochemistry and Molecular Biology(2020)10.1016/j.jsbmb.2020.105787

N/A

0DataRank · unranked

11 citations

Michael J. Reddish, Stella A. Child, Clayton J. Wilkey, Donald F. Stec, F. Peter Guengerich +1 more

Impact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.012829

N/A

0DataRank · unranked

7 citations

F. Peter Guengerich, Pratibha P. Ghodke

Inhibition of Cytochrome P450 Enzymes by Drugs-Molecular Basis and Practical Applications

Biomolecules & Therapeutics(2021)10.4062/biomolther.2021.102

N/A

0DataRank · unranked

60 citations

F. Peter Guengerich