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A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance

The Journal of Experimental Medicine(2021)10.1084/jem.20210759Source: DataRank Database

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance is a research paper published in The Journal of Experimental Medicine (2021). On theSindex it has a DataRank of 0. It has been cited 56 times.

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Open Access56 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 6.83)OA: greenTopics (99)Linked Datasets (4)DataCite Reuse (4)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (3)

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Context only (not used in score)

Findable (2/2)

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Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
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Reusable (0/3)

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Authors (16)

Julia A. Belk ORCID,Alice Chan ORCID,Jiaxi Wang ORCID,Alexander R. Gupta ORCID,Quanming Shi ORCID

Live enrichment

PubMed:34115115 PMC:PMC8203485 OpenAlex:https://openalex.org/W3134272917

National Institutes of Health

Grant: 2T32DK007418-36A1

Diabetes, Endocrinology & Metabolism Training Grant

National Institutes of Health

Grant: P30 DK063720

National Institutes of Health

Grant: 1S10OD021822-01

BD FACSAria Fusion Cell Sorter

National Institutes of Health

Grant: K08CA230188

NIH HHS

Grant: S10 OD021822

NIDDK NIH HHS

Grant: T32 DK007418

NIAID NIH HHS

Grant: T32 AI007334

NIAID NIH HHS

Grant: T32 AI125222

NIGMS NIH HHS

Grant: T32 GM136534

National Institutes of Health

Grant: 5P30DK063720-03

ISLET PRODUCTION FACILITY CORE

National Institutes of Health

Grant: 5K08CA230188-03

Single cell epigenomics in cancer immunity and immunotherapy

Arsenal Biosciences

Parker Institute for Cancer Immunotherapy

Juvenile Diabetes Research Foundation Center of Excellence in Northern California

Larry L. Hillblom Foundation

Burroughs Wellcome Fund

Cancer Research Institute

Endocrine Fellows Foundation

FWCI

6.83

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: cc-by-nc-sa

repositoryhttps://escholarship.org/uc/item/61f9b398

publisherhttps://rupress.org/jem/article-pdf/doi/10.1084/jem.20210759/1792795/jem_20210759.pdf

journalhttps://doi.org/10.1084/jem.20210759

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34115115

Fields of Study

Diabetes and associated disordersImmune Cell Function and InteractionT-cell and B-cell Immunology0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsAutoimmunityCD8-Positive T-LymphocytesCell ProliferationChemotaxisCross-PrimingCytotoxicity, ImmunologicDiabetes Mellitus, Type 1Disease Models, AnimalEpigenesis, GeneticGain of Function MutationHeterozygoteHumansImmune ToleranceMiceMutationPhenotypeSTAT3 Transcription FactorUp-Regulation

MeSH Terms

Gain of Function MutationAnimalsChemotaxisCytotoxicity, ImmunologicDiabetes Mellitus, Type 1Disease Models, AnimalHeterozygoteHumansImmune ToleranceMutationPhenotypeAutoimmunityUp-RegulationCD8-Positive T-LymphocytesEpigenesis, GeneticCross-PrimingCell ProliferationSTAT3 Transcription FactorMice

Keywords

BiologyCD8T-cell receptorEffectorSTAT3T cellCell biologyCytotoxic T cellImmunologyTransgeneMutationAntigenImmune systemGeneticsSignal transductionGeneIn vitroCytotoxicity, ImmunologicSTAT3 Transcription Factor570Pediatric Research InitiativeHeterozygoteCytotoxicity610AutoimmunityCD8-Positive T-LymphocytesAutoimmune DiseaseMedical and Health SciencesEpigenesis, GeneticMiceCross-PrimingGeneticImmunologicDiabetes MellitusImmune Tolerance2.1 Biological and endogenous factorsAnimalsHumansAetiologyMetabolic and endocrineCell ProliferationPediatricAnimalChemotaxisDiabetesBrief Definitive ReportUp-RegulationDisease Models, AnimalGood Health and Well BeingDiabetes Mellitus, Type 1PhenotypeGain of Function MutationDisease ModelsType 1Epigenesis

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

10.6084/m9.figshare.16551022.v1figshare

Additional file 1 of AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

10.6084/m9.figshare.16551022figshare

Additional file 2 of AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

10.6084/m9.figshare.16551025.v1figshare

Additional file 2 of AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

10.6084/m9.figshare.16551025figshare

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance

FAIR Checklist

Authors (16)

Funding (18 grants)

Impact

Open Access

Topics

Linked Datasets (4)

Annotations (Europe PMC)