CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase is a dataset published in Nucleic Acids Research (2022). On theSindex it has a DataRank of 1.0, placing it in the top 19.5% of the data-sharing corpus. It has been cited 46 times, with 34 citing works in its 1-hop citation network. Its calibrated FAIR score is 52/100.
Ranks in the top 19% for downstream scientific impact
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
“CIViC data is available under a creative commons CC0 (public domain dedication) and can be viewed onhttps: //civicdb.org.”
The paper gives a web address (https://civicdb.org) rather than a persistent-identifier scheme string for its own dataset. [majority verdict 'partial' (3/4 passes agreed)]
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“CIViC data is available under a creative commons CC0 (public domain dedication) and can be viewed on https://civicdb.org.”— not found in the paper; verdict downgraded
The host is a project website (civicdb.org), not a recognised curated repository from re3data/FAIRsharing. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/4 passes agreed)]
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
“CIViC data is available under a creative commons CC0 (public domain dedication) and can be viewed on https://civicdb.org.”— not found in the paper; verdict downgraded
The dataset identifier (URL) appears only in the body text, not as a reference-list entry. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/4 passes agreed)]
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“CIViC data is available under a creative commons CC0 (public domain dedication) and can be viewed on https://civicdb.org. All underlying code is available on GitHub under an MIT license (https://github.com/griffithlab/civic-v2). Data is available via API (https://griffithlab.github.io/civic-v2/) and regular releases in TSV and VCF format (https://civicdb.org/releases/main).”— not found in the paper; verdict downgraded
The statement points to a website (CIViCdb) and a GitHub repository, not to a repository record with an accession or DOI. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (2/4 passes agreed)]
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“Table 1. CIViC curation statistics from original publication to current”
The paper includes a table that itemises the dataset's content (variants, genes, sources, etc.), serving as an itemised inventory. [majority verdict 'yes' (3/4 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“CIViC data is available under a creative commons CC0 (public domain dedication) and can be viewed on https://civicdb.org.”— not found in the paper; verdict downgraded
The data availability statement provides a direct link to the data with no precondition stated. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (2/4 passes agreed)]
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“CIViC is an open-access, open-source, fully transparent knowledgebase for the expert crowdsourcing of Clinical Interpretation of Variants in Cancer ( civicdb.org) first released in 2017 (1)( F i g u r e1).”
The paper labels the data as 'open-access' and as being under a 'public domain dedication', which are explicit access-level labels. [majority verdict 'yes' (3/4 passes agreed)]
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
The CIViC data are literature-derived variant interpretations, not sensitive human-subject data, and no gatekeeper is named.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
The paper does not state how long the data will remain available or make any persistence commitment. [majority verdict 'no' (3/4 passes agreed)]
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
“TSV and VCF”— not found in the paper; verdict downgraded
The paper states that data are released in TSV and VCF formats, both of which are open, community-standard formats. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (2/4 passes agreed)]
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
“Human Phenotype Ontology (HPO) (23) terms were added as anewfieldtoEIDs.”
The paper names Human Phenotype Ontology (HPO), an OBO ontology and a community data standard. [majority verdict 'yes' (3/4 passes agreed)]
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
The paper does not give a specific identifier (accession, DOI, RRID) for any external resource it builds on; external resources appear only as bare names or reference-list entries.
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
“CIViC data is available under a creative commons CC0 (public domain dedication)”
CC0 is an open standard licence conformant with the Open Definition.
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
“(N = 328 as of 15 August 2022, Supplemental Figure S1)”
The paper uses a date ('15 August 2022') to pin the snapshot of the data, but no version token is given.
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
“All underlying code is available on GitHub under an MIT license (https://github.com/griffithlab/civic-v2).”
The paper gives a machine-resolvable code-repository URL (GitHub) for the study's own code.
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“U01CA209936, U24CA237719”
The paper lists specific grant numbers (e.g., U01CA209936, U24CA237719) attached to named funders.
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“CIViC Curators extract detailed evidence of the clinical significance of variants in cancer from the peer-reviewed, published literature and selected conference abstracts to contribute to the resource.”— not found in the paper; verdict downgraded
The production method is described in generic terms (curation from literature) without naming specific instruments, kits, or software versions. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/4 passes agreed)]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
“Additional documentation and help can be found in our help documentation: https://civicdb.org/pages/help.”
The paper references external documentation but does not include a codebook within the article or state that it ships with the data. [majority verdict 'partial' (2/4 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.578
From this paper's citation signal
Citation Network Contribution
0.463
From 21 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 34 citers.
NCI
Grant: U01CA209936
NCI
Grant: U24CA237719
NCI
Grant: K22CA188163
Washington University Institute of Clinical and Translational Sciences
Grant: UL1TR002345
Clinical Genome Resource
Grant: 5U24HG009649
NHGRI
Grant: 861329
Studying Ciliary Signaling in Development and Disease
NHGRI
Grant: U41 HG008735
NHGRI
Grant: R00HG010157
NIH
Grant: R00HG007940
NHGRI NIH HHS
Grant: U24 HG009650
NCI NIH HHS
Grant: P30 CA008748
NHGRI NIH HHS
Grant: U24 HG012557
NCI NIH HHS
Grant: U24 CA258115
NHGRI NIH HHS
Grant: U24 HG009649
NCATS NIH HHS
Grant: UH3 TR002881
National Institutes of Health
Grant: 5U41HG008735-02
The Disease Ontology Project: mechanistic profiles of human disease for biomedical and clinical research
National Institutes of Health
Grant: 4R00HG007940-03
Integrated Analysis & Interpretation of Whole Genome Exome & Transcriptome Sequen
National Institutes of Health
Grant: 5U01CA209936-03
DEVELOPMENT OF INFORMATICS RESOURCES FOR INTERPRETATION OF CLINICALLY ACTIONABLE VARIANTS IN CANCER
National Institutes of Health
Grant: 5U24HG009649-06
Baylor College of Medicine/Stanford University Clinical Genome Resource (CLINGEN)
National Institutes of Health
Grant: 1UL1TR002345-01
Washington University Institute of Clinical and Translational Sciences
National Institutes of Health
Grant: 4R00HG010157-04
Tools for Normalizing and Interpreting the Clinical Actionability of Genomic Variants
National Institutes of Health
Grant: 1K22CA188163-01
DEFINING THE REGULATORY, NON-CODING, MUTATIONAL LANDSCAPE OF BREAST CANCER
National Institutes of Health
Grant: 1U24CA237719-01
Standardized and Genome-Wide Clinical Interpretation of Complex Genotypes for Cancer Precision Medicine
Amazon Web Services Open Data
Berlin Institute of Health
Google Big Query
National Center for Advancing Translational Sciences
VHL Alliance Research
St. Louis Children's Hospital and Washington University School of Medicine
Starbucks Clinical Genetics/Genomics Research Studentship
Bhalwani Family Charitable Foundation
Charité - Universitätsmedizin Berlin
Cancer Moonshot and Childhood Cancer Data Initiative
National Institutes of Health
Fields of Study
MeSH Terms
Keywords
Sustainable Development Goals