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PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB

Nucleic Acids Research(2025)10.1093/nar/gkaf540Source: DataRank Database

PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB is a research paper published in Nucleic Acids Research (2025). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (19 grants)Impact (FWCI 6.30)OA: goldTopics (37)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Lindsey Doyle ORCID,Maria Puiu ORCID,Abigail Kelly ORCID,Andrew Nelson ORCID,Alex Kaiser

Live enrichment

PubMed:40548935 PMC:PMC12205998 OpenAlex:https://openalex.org/W4411623087

Biotechnology and Biological Sciences Research Council

Grant: BB/T008695/1

NLD (Newcastle-Liverpool-Durham) Doctoral Training Partnership 3

responsive mode

Grant: BB/Y003659/1

BREX phage defence: expanding the role of cyclic nucleotide signalling in the prokaryotic immune system

NIH

Grant: R01GM105691

NIH

Grant: R35GM148166

BKK

Grant: R15GM140375

NIGMS NIH HHS

Grant: R01 GM129325

NCI NIH HHS

Grant: P30 CA015704

National Institutes of Health

Grant: 5R35GM148166-03

Biophysical and structural studies of protein and enzyme mechanism, evolution, and engineering

National Institutes of Health

Grant: 3R15GM140375-01A1S1

Characterization of the Bacterial BREX Phage Restriction System - Administrative Supplement

National Institutes of Health

Grant: 5R01GM105691-02

MegaTALS: hyperspecific reagents for targeted gene modification and correction

National Institutes of Health

Grant: 3P30CA015704-42S2

Cancer Center Support Grant

National Institutes of Health

Grant: 6R01GM105691-09

MegaTALS: hyperspecific reagents for targeted gene modification and correction

National Institutes of Health

Grant: 5R01GM129325-08

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling

Fred Hutchinson Cancer Center

Lister Institute Prize Fellowship to A.K. and T.R.B.

New England Biolabs

Lister Institute Prize Fellowship to A.K. and T.R.B.

New England Biolabs

Fred Hutchinson Cancer Center

FWCI

6.30

Citation Percentile

1.0%

Citation Trend

2026

goldLicense: cc-by

journalhttps://academic.oup.com/nar/article-pdf/53/12/gkaf540/63551167/gkaf540.pdf

publisherhttps://academic.oup.com/nar/article-pdf/53/12/gkaf540/63551167/gkaf540.pdf

journalhttps://doi.org/10.1093/nar/gkaf540

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40548935

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12205998

Fields of Study

Bacteriophages and microbial interactionsBacterial Genetics and BiotechnologyRNA modifications and cancer0301 basic medicine03 medical and health sciencesBacteriophagesBacterial ProteinsModels, MolecularViral ProteinsMetalsDNA-Binding Proteins

MeSH Terms

Bacterial ProteinsBacteriophagesDNA-Binding ProteinsMetalsModels, MolecularViral Proteins

Keywords

BiologyNucleaseBacteriophagePhagemidDNAPlasmidGeneticsEffectorOligonucleotideBiochemistryGeneEscherichia coliModels, MolecularDNA-Binding ProteinsViral ProteinsBacterial ProteinsMetalsMolecular and Structural BiologyBacteriophagesArticle

Sustainable Development Goals

SDG 0: Life below waterSDG 0: Reduced inequalities