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Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.21.913772Source: DataRank Database

Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 5 times.

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0DataRank · unranked

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Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)OA: greenTopics (46)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Tony Ngo ORCID,Irina Kufareva ORCID,Tracy M. Handel ORCID,Bryan S. Stephens ORCID

Live enrichment

PubMed:19965766 OpenAlex:https://openalex.org/W3001632865

National Institutes of Health

Grant: 5R01GM117424-02

Chemokine interaction with CXCR4 and ACKR3: structure and activation mechanisms

National Institutes of Health

Grant: 5R01AI118985-04

The structural plasticity of chemokine and gp120 recognition by CCR5

National Institutes of Health

Grant: 5T32GM007752-12

CELLULAR AND MOLECULAR PHARMACOLOGY

National Institutes of Health

Grant: 5T32GM008326-09

MOLECULAR BIOPHYSICS TRAINING PROGRAM

National Health and Medical Research Council (NHMRC)

Grant: 1145746

Computational and structural studies of protein-GPCR interactions underlying HIV infection

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/01/21/2020.01.21.913772.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.01.21.913772

repositoryhttps://doi.org/10.1101/2020.01.21.913772

https://doi.org/10.1126/scisignal.aay5024

Fields of Study

Chemokine receptors and signalingvaccines and immunoinformatics approachesImmunotherapy and Immune Responses0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

Chemokine receptorG protein-coupled receptorChemokineBiologyC-C chemokine receptor type 7MutagenesisLigand (biochemistry)Computational biologyCell biologyReceptorCXCR4Signal transductionChemistryBiochemistryMutationGeneModels, Molecular570Protein StructureReceptors, CXCR4610CHO CellsQuaternaryCricetulusModelsReceptors2.1 Biological and endogenous factorsSite-DirectedAnimalsHumansProtein Structure, QuaternaryCancerMolecularBiological SciencesChemokine CXCL12HEK293 CellsBiochemistry and cell biologyMultiprotein ComplexesMutagenesis, Site-DirectedGeneric health relevance

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being