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Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductase

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.09.434557Source: DataRank Database

Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductase is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)OA: greenTopics (43)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (4)

Irina F. Sevrioukova ORCID,Christopher J. Thibodeaux ORCID,Karine Auclair ORCID,Julie Ducharme

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3135274413

Natural Sciences and Engineering Research Council of Canada

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01ES025767-08

Toxicological importance of CYP3A4 catalysis and inhibition

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/03/09/2021.03.09.434557.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.03.09.434557

repositoryhttps://doi.org/10.1101/2021.03.09.434557

repositoryhttps://escholarship.mcgill.ca/concern/articles/pg15bk65h

Fields of Study

Pharmacogenetics and Drug MetabolismAnalytical Chemistry and ChromatographyComputational Drug Discovery Methods0301 basic medicine03 medical and health sciences

Keywords

CYP3A4ChemistryHydrogen–deuterium exchangeCytochrome P450StereochemistryAllosteric regulationCytochrome P450 reductaseHelix (gastropod)EnzymeLigand (biochemistry)BiophysicsMolecular dynamicsBiochemistryCytochrome cComputational chemistryReceptorHydrogenBiologyCoenzyme Q – cytochrome c reductaseModels, Molecular570Protein ConformationMolecularPeptides and proteinsRatsSubstrate SpecificityModels617Structural dynamicsAnimalsCytochrome P-450 CYP3AHumansReaction rate theorySurface interactionsProtein Interaction MapsHydrogen isotopesNADPH-Ferrihemoprotein ReductaseProtein Binding

Sustainable Development Goals

SDG 0: Good health and well-being