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Regulatory approved monoclonal antibodies contain framework mutations predicted from human antibody repertoires

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.22.449488Source: DataRank Database

Regulatory approved monoclonal antibodies contain framework mutations predicted from human antibody repertoires is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2021). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (1 grants)OA: greenTopics (27)IDs (PubMed)SDGs (1)

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Authors (7)

Sophia A. Ulmer,Emily R. Rhodes,Matías Gutiérrez-González ORCID,Brandon J. DeKosky ORCID,Kayla G. Sprenger ORCID

Live enrichment

PubMed:19767382

National Institutes of Health

Grant: 5R01AI141452-04

The influence of evolutionary landscapes on protective antibody development

greenLicense: CC BY

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2021/06/22/2021.06.22.449488.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2021.06.22.449488

https://doi.org/10.1101/2021.06.22.449488

https://europepmc.org/articles/pmc8503325?pdf=render

https://doi.org/10.3389/fimmu.2021.728694

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

antibody repertoiresImmunologyDNA Mutational AnalysisImmunoglobulin Variable RegionEpitopes, T-LymphocyteMolecular Dynamics Simulationdeep sequencingDrug DevelopmentDrug StabilityDatabases, GeneticHumansDrug Approvalantibody therapeuticsaffinity maturationModels, GeneticProtein StabilityUnited States Food and Drug AdministrationAntibodies, MonoclonalRC581-607United StatesMutationmonoclonal antibodiesImmunologic diseases. AllergyImmunoglobulin Heavy Chains

Sustainable Development Goals

SDG 3: 3. Good health