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Ezh2 knockout in B cells impairs plasmablast differentiation and ameliorates lupus-like disease in MRL/ lpr mice

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.21.500990Source: DataRank Database

Ezh2 knockout in B cells impairs plasmablast differentiation and ameliorates lupus-like disease in MRL/ lpr mice is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (1 grants)OA: greenTopics (42)IDs (PubMed, OpenAlex)SDGs (2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Mikhail G. Dozmorov ORCID,Colleen E Strohlein ORCID,Sheldon Bastacky ORCID,Amr H. Sawalha ORCID,Xiaoqing Zheng ORCID

Live enrichment

PubMed:20819859 OpenAlex:https://openalex.org/W4286615516

National Institutes of Health

Grant: 1R01AI097134-01A1

Role of DNA methylation in lupus

greenLicense: Wiley Online Library User Agreement

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/07/22/2022.07.21.500990.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.07.21.500990

repositoryhttps://doi.org/10.1101/2022.07.21.500990

https://doi.org/10.1002/art.42492

Fields of Study

Immune Cell Function and InteractionT-cell and B-cell ImmunologySingle-cell and spatial transcriptomics0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

CD19BiologyB cellImmunoglobulin class switchingSystemic lupus erythematosusNaive B cellXBP1Molecular biologyCD40EZH2Cellular differentiationT cellImmunologyAntibodyFlow cytometryIn vitroGene expressionCytotoxic T cellRNAImmune systemAntigen-presenting cellInternal medicineMedicineGeneMice, KnockoutMice, Inbred MRL lprReceptors, Antigen, B-CellCell DifferentiationMiceLeukocytes, MononuclearAnimalsHumansLupus Erythematosus, SystemicEnhancer of Zeste Homolog 2 ProteinRNA, MessengerAutoantibodies

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being