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Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.08.515634Source: DataRank Database

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.

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Enrichment:Funding (5 grants)OA: greenTopics (23)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (4)

Xiaohui Lin ORCID,Shan Zha ORCID,John M. Pascal ORCID,Marie-France Langelier ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W4308564938

National Institutes of Health

Grant: 1R01CA271595-01A1

The non-catalytic function of PARP2 in DNA repair and cancer therapy

National Institutes of Health

Grant: 5R01CA259037-03

Tuning PARP-1 retention and release on DNA breaks

Canadian Institutes of Health Research

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01CA226852-02

The catalytic and non-catalytic functions of PARP1 in cancer biology

National Institutes of Health

Grant: 5R01LM013039-02

HealthyMe/MiSalud Smartphone Application: Identifying Mechanisms to Engage African Americans and Hispanics in Personal Health Libraries

greenLicense: http://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2022/11/08/2022.11.08.515634.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.11.08.515634

repositoryhttps://doi.org/10.1101/2022.11.08.515634

https://doi.org/10.1126/sciadv.adf7175

Fields of Study

PARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisElectrostatic Discharge in Electronics0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Allosteric regulationPARP1DNA damagePoly ADP ribose polymeraseDNAChemistryDNA repairCell biologyBiologyCancer researchBiochemistryEnzymePolymeraseBiomedicine and Life SciencesPoly(ADP-ribose) Polymerase InhibitorsNaphthyridinesPiperazines

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being