John M. Pascal

MedicineBiochemistry, Genetics and Molecular BiologyEngineeringImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 27 papers. Top paper: “ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification”.

ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105397

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0.574DataRank · unranked

45 citations

John M. Pascal, Élise Rouleau-Turcotte

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

Nucleic Acids Research(2020)10.1093/nar/gkaa718

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0DataRank · unranked

90 citations

Brian J. Lee, Élise Rouleau-Turcotte, Marie-France Langelier, Xiaohui Lin, Verna M. Estes +3 more

Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.10.032

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0DataRank · unranked

21 citations

Rhys C. Brooks, Aleksandr Sverzhinsky, John M. Pascal, Alan E. Tomkinson, Yoshihiro Matsumoto

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Cell Reports(2020)10.1016/j.celrep.2020.107922

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0DataRank · unranked

18 citations

Jonathon Klein, Yumei Zheng, Nicole O. Glenn, Travis Eisemann, Klementina Fon Tacer +14 more

An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

Nucleic Acids Research(2020)10.1093/nar/gkaa1188

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0DataRank · unranked

32 citations

Ishtiaque Rashid, Aleksandr Sverzhinsky, Yasin Pourfarjam, Miaw-Sheue Tsai, Tom Ellenberger +5 more

ADP‐ribosyltransferases, an update on function and nomenclature

FEBS Journal(2021)10.1111/febs.16142

N/A

0DataRank · unranked

330 citations

Ivan Ahel, Matthias Altmeyer, Alan Ashworth, Péter Bai, Paul Chang +42 more

CARM1 regulates replication fork speed and stress response by stimulating PARP1

Molecular Cell(2021)10.1016/j.molcel.2020.12.010

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0DataRank · unranked

113 citations

Jean‐Philippe Gagné, Takaaki Yasuhara, Jessica Jackson, Sneha Saxena, Marie-France Langelier +7 more

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

Nature Communications(2021)10.1038/s41467-021-25252-9

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0DataRank · unranked

75 citations

Jiji Chen, Shar-yin N. Huang, Yijun Su, Wenjie Wang, Keli Agama +5 more

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

Nature Communications(2021)10.1038/s41467-021-27043-8

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0DataRank · unranked

72 citations

Ramya Billur, Aleksandr Sverzhinsky, Ben E. Black, John M. Pascal, Marie-France Langelier

Mechanisms of Nucleosome Reorganization by PARP1

International Journal of Molecular Sciences(2021)10.3390/ijms222212127

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0DataRank · unranked

39 citations

D. K. Nilov, Sergey V. Pushkarev, E. Yu. Kotova, Н. С. Герасимова, М. П. Кирпичников +6 more

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100921

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0DataRank · unranked

14 citations

Michal Hammel, Aleksandr Sverzhinsky, Miaw-Sheue Tsai, John M. Pascal, John A. Tainer +2 more

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP- ribose modifications

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.19.444852

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0DataRank · unranked

6 citations

Ramya Billur, Aleksandr Sverzhinsky, Ben E. Black, John M. Pascal, Marie-France Langelier

Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a new mode of engaging poly(ADP-ribose)

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.15.472832

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0DataRank · unranked

0 citations

Heddy Soufari, Morgan Dasovich, Isabel Uribe, Shang-Jung Cheng, Anthony K. L. Leung +2 more

Structural basis for allosteric PARP-1 retention on DNA breaks

Science(2020)10.1126/science.aax6367

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0DataRank · unranked

336 citations

Marie-France Langelier, Uday Kiran Velagapudi, Mark A. Hancock, Jamin D. Steffen, Ramya Billur +9 more

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro

International Journal of Molecular Sciences(2022)10.3390/ijms23137107

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0DataRank · unranked

17 citations

Fu‐Kai Hsieh, Han-Wen Chang, N. V. Maluchenko, Marie-France Langelier, John M. Pascal +4 more

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

Cell chemical biology(2022)10.1016/j.chembiol.2022.11.006

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0DataRank · unranked

11 citations

Marie-France Langelier, Jessica Gartrell, Ilsa T. Kirby, Daniel J. Sanderson, Daniel S. Bejan +9 more

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.08.515634

N/A

0DataRank · unranked

0 citations

Xiaohui Lin, Shan Zha, John M. Pascal, Marie-France Langelier

PARP1 associates with R-loops to promote their resolution and genome stability

Nucleic Acids Research(2023)10.1093/nar/gkad066

N/A

0DataRank · unranked

90 citations

Parminder Kaur, Sofiane Y. Mersaoui, Daniela Muoio, Zhiyan Silvia Liu, Maxwell Bannister +8 more

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

Science Advances(2023)10.1126/sciadv.adf7175

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0DataRank · unranked

50 citations

Xiaohui Lin, Shan Zha, John M. Pascal, Marie-France Langelier

PARP–nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance

Current Opinion in Structural Biology(2023)10.1016/j.sbi.2023.102643

N/A

0DataRank · unranked

7 citations

John M. Pascal

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)

Molecular Cell(2024)10.1016/j.molcel.2024.10.024

N/A

0DataRank · unranked

25 citations

Manija Mirhasan, Karine Gilbert, Aleksandr Sverzhinksy, Alexandra Fürtös, John M. Pascal +1 more

Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks

Biochemical Journal(2024)10.1042/bcj20230406

N/A

0DataRank · unranked

5 citations

Élise Rouleau-Turcotte, Ramya Billur, Xuwei Shao, Manisha Patil, Ben E. Black +3 more

A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.20.594972

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0DataRank · unranked

0 citations

Ramya Billur, Marie-France Langelier, Tanaji T. Talele, John M. Pascal, Ben E. Black +1 more

A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation

Molecular Cell(2025)10.1016/j.molcel.2025.01.004

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0DataRank · unranked

8 citations

Ramya Billur, Marie-France Langelier, Tanaji T. Talele, John M. Pascal, Ben E. Black +1 more

PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair

DNA repair(2025)10.1016/j.dnarep.2025.103898

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0DataRank · unranked

3 citations

John M. Pascal, Marie-France Langelier

Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13

Nature Communications(2025)10.1038/s41467-024-55666-0

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0DataRank · unranked

5 citations

Temitope Gafaar, Jijin R. A. Kuttiyatveetil, Aleksandr Sverzhinsky, C Y Chen, Minghui Xu +4 more

Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

Cell Reports(2022)10.1016/j.celrep.2022.111529

N/A

0DataRank · unranked

23 citations

Heddy Soufari, Morgan Dasovich, Isabel Uribe, Manija Mirhasan, Shang-Jung Cheng +3 more