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Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.29.522270Source: DataRank Database

Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2022). On theSindex it has a DataRank of 0.519. It has been cited 10 times, with 9 citing works in its 1-hop citation network.

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0.519DataRank · unranked

Scored on demand from live citation data

Open Access10 citations · 9 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)OA: greenTopics (42)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 69%Citation Network 31%

Base Score Contribution

0.360

From this paper's citation signal

Citation Network Contribution

0.159

From 7 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 9 citers.

Comparison of methods for building polygenic scores for diverse populations
Human Genetics and Genomics Advances202419 citations52 referencesContributes 0.058
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations
Nature Genetics202518 citations54 referencesContributes 0.055
Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations
The American Journal of Human Genetics20254 citations54 referencesContributes 0.030
The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes
medRxiv20241 citations43 referencesContributes 0.016
Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation
Nature Reviews Endocrinology202515 citations227 referencesContributes 0.012

Authors (13)

Masahiro Kanai ORCID,Taotao Tan ORCID,Mireille Kamariza ORCID,Kristin Tsuo ORCID,Kai Yuan ORCID

Live enrichment

PubMed:26207759 OpenAlex:https://openalex.org/W4313314535

National Institutes of Health

Grant: 5U01HG011719-03

Enabling improved applicability and transferability of polygenic scores across diverse populations- a focus on South Asians

National Institutes of Health

Grant: 5R00AG062787-04

Genome-wide analysis of late-onset Alzheimer's disease using intergenerational, multi-trait, and cross-ancestry data

European Commission

Grant: 101016775

International consortium for integrative genomics prediction

National Institutes of Health

Grant: 3U01MH109539-04S1

2/7 Psychiatric Genomics Consortium: Finding Actionable Variation

National Institutes of Health

Grant: 1ZIADK013039-04

Molecular modeling of soluble proteins

National Institutes of Health

Grant: 3K01DK114379-04S1

Genetics and gene regulation in the inflammatory bowel diseases

National Institutes of Health

Grant: 4R00MH117229-03

Generalizing polygenic risk prediction methods across populations for insights into psychiatric disease

National Institutes of Health

Grant: 5K01MH121659-04

A framework enabling the genomic analysis of psychiatric traits across admixed populations.

National Institutes of Health

Grant: 5R01DK129364-02

Identification and characterization of inflammatory bowel disease causal variants

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/06/21/2022.12.29.522270.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2022.12.29.522270

repositoryhttps://doi.org/10.1101/2022.12.29.522270

repositoryhttps://zenodo.org/record/8218147

Fields of Study

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and Animals0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Genome-wide association studyBiobankGenetic architectureGenetic genealogyGeneralizability theoryBiologyGenetic associationPopulationEvolutionary biologyGeneticsDemographyQuantitative trait locusSingle-nucleotide polymorphismStatisticsGenotypeGeneMathematicsMedical SciencesCell Phenomenamulti-ancestryLife Sciences610Genetics and GenomicsQH426-470RC31-1245ArticleBiomedical Informaticspolygenic risk scoresMedical Molecular Biologygenome-wide association studiesMedical SpecialtiesMedicine and Health Sciencesand ImmunityMedical GeneticsInternal medicineBiological Phenomena

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