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FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.22.529557Source: DataRank Database

FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0.

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Authors (9)

Samantha L. Yuen ORCID,Andrew R. Thompson ORCID,Lauren N. Roelike,Robyn T. Rebbeck ORCID,Philip A. Bidwell ORCID

Live enrichment

PubMed:36865289 OpenAlex:https://openalex.org/W4321486634

National Institutes of Health

Grant: 5R01HL139065-37

Structural Dynamics of Cardiac Muscle Calcium ATPase Regulation

National Institutes of Health

Grant: 5R37AG026160-14

Site-Directed Modification of Muscle Protein Structural Dynamics

greenLicense: CC BY

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/02/22/2023.02.22.529557.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.02.22.529557

repositoryhttp://dx.doi.org/10.1101/2023.02.22.529557

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36865289

Fields of Study

Cardiac electrophysiology and arrhythmiasNeuroscience and Neural EngineeringReceptor Mechanisms and Signaling0303 health sciences03 medical and health sciences

Keywords

SERCASmall moleculeEndoplasmic reticulumAllosteric regulationHigh-throughput screeningFörster resonance energy transferChemistryATPaseDrug discoveryBiosensorBiophysicsP-type ATPaseComputational biologyBiochemistryFluorescenceBiologyEnzymeArticle

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being