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Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.02.539100Source: DataRank Database

Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)OA: greenTopics (36)IDs (PubMed, OpenAlex)SDGs (2)

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Accessible (1/2)

Open Access

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Reusable (0/3)

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Authors (11)

Thao N. Huynh ORCID,Catherine C.Y. Chang ORCID,Darcy B. Pooler ORCID,Dylan B. Ness ORCID,Lionel D. Lewis ORCID

Live enrichment

PubMed:19162232 OpenAlex:https://openalex.org/W4367844419

National Institutes of Health

Grant: 7R21CA167418-02

Feasibility of Virtual Agent Cervical Cancer Education for Hispanic Farmworkers

National Institutes of Health

Grant: 5R01AG063544-02

Alleviating lysosomal lipid defects in ADRD by blocking cholesterol storage

National Institutes of Health

Grant: 3P30CA023108-41S8

Cancer Center Support Grant

National Institutes of Health

Grant: 5R37CA212187-06

Paired-agent imaging for resection during surgery (PAIRS) for head & neck cancers

National Institutes of Health

Grant: 5F31NS110317-02

Nanoparticles encapsulating a potent cholesterol storage inhibitor as a novel therapeutic to treat Alzheimer's disease

National Institutes of Health

Grant: 3P20GM113132-05S1

Pellegrini Administrative Supplements for Helium Recovery Systems

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/05/02/2023.05.02.539100.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.05.02.539100

repositoryhttp://dx.doi.org/10.1101/2023.05.02.539100

https://doi.org/10.1101/2023.05.02.539100

Fields of Study

Cholesterol and Lipid MetabolismAlzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Keywords

LiposomePharmacologyPhosphatidylcholineNeuroinflammationChemistryBiodistributionToxicityBiochemistryMedicineInternal medicineDiseaseIn vitroPhospholipidF12511cholesterolamyloidMice, TransgenicArticleMiceAlzheimer DiseaseTandem Mass Spectrometrycholesteryl esterLiposomesACAT1/SOAT1HumansAnimalsnanoparticlesDSPE-PEGTissue DistributionAnilidestauAcetyl-CoA C-AcetyltransferaseAlzheimer’s disease

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being