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Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.28.573261Source: DataRank Database

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (4 grants)OA: greenTopics (30)IDs (PubMed, OpenAlex)Annotations (1)SDGs (2)

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Authors (12)

Michael P. East ORCID,Tuomo Laitinen ORCID,Carla Alamillo‐Ferrer ORCID,Erkka Hartikainen,Carrow I. Wells ORCID

Live enrichment

PubMed:38234837 OpenAlex:https://openalex.org/W4390367187

National Science Foundation

Grant: 1828183

MRI: Upgrade of a 600 MHz Spectrometer for high-sensitivity Nuclear Magnetic Resonance (NMR)

European Commission

Grant: 115766

Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery

Wellcome Trust

Grant: 106169

A UK Hub to Catalyse Open Target Discovery.

National Science Foundation

Grant: 1726291

MRI: Acquisition of a Mass Spectrometer

greenLicense: cc-by-nc

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/12/28/2023.12.28.573261.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.12.28.573261

repositoryhttp://dx.doi.org/10.1101/2023.12.28.573261

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38234837

Fields of Study

Microbial Natural Products and BiosynthesisMicrotubule and mitosis dynamicsComputational Drug Discovery Methods0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

KinomeOxindoleComputational biologyDrug discoveryKinaseQuantitative structure–activity relationshipProfiling (computer programming)ChemistryBiologyStereochemistryCombinatorial chemistryComputer scienceBiochemistryModels, MolecularMolecular StructureDose-Response Relationship, Drug610Quantitative Structure-Activity RelationshipProtein Serine-Threonine Kinases540ArticleOxindolesHumansProtein Kinase Inhibitors

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Clean water and sanitation

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

FAIR Checklist

Authors (12)

Funding (4 grants)

Open Access

Topics

Annotations (Europe PMC)