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Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.15.575737Source: DataRank Database

Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2024). On theSindex it has a DataRank of 0.711. It has been cited 21 times, with 17 citing works in its 1-hop citation network.

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0.711DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access21 citations · 17 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

Dryad10.5061/dryad.pk0p2ngvp

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)OA: greenTopics (45)Linked Datasets (3)DataCite Reuse (3)IDs (PubMed, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 65%Citation Network 35%

Base Score Contribution

0.464

From this paper's citation signal

Citation Network Contribution

0.247

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 17 citers.

Sonic Hedgehog Mediates High Frequency-Dependent Deep Brain Stimulation for the Correction of Motor Deficits in a Parkinson’s Disease Model
Neuroscience Bulletin20245 citations21 referencesContributes 0.085
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
Cell Death and Disease20245 citations61 referencesContributes 0.029
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease
eLife202419 citations107 referencesContributes 0.028
Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons
eLife20243 citations68 referencesContributes 0.020
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2 G2019S model of Parkinson’s disease
bioRxiv (Cold Spring Harbor Laboratory)20247 citations106 referencesContributes 0.020

Authors (7)

Ebsy Jaimon ORCID,Yu‐En Lin ORCID,Jonas Nikoloff ORCID,Francesca Tonelli ORCID,Dario R. Alessi ORCID

Live enrichment

PubMed:38293195 OpenAlex:https://openalex.org/W4390918418

National Institutes of Health

Grant: 2P30AG019610-11

Education and Information Transfer Core

National Institutes of Health

Grant: 5T32GM007276-36

Cellular and Molecular Biology Training Program

National Institutes of Health

Grant: 5U24NS072026-03

National Brain and Tissue Resource for Parkinson's Disease and Related Disorders

UK Research and Innovation

Grant: MC_UU_00018/1

Understanding Signalling Pathways Mutated in Inherited Disorders

National Institutes of Health

Grant: 5P30AG072980-02

Arizona Alzheimer's Disease Research Center

NIA NIH HHS

Grant: P30 AG019610

NIA NIH HHS

Grant: P30 AG072980

NIGMS NIH HHS

Grant: T32 GM007276

NINDS NIH HHS

Grant: U24 NS072026

greenLicense: cc-by

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2024/01/16/2024.01.15.575737.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2024.01.15.575737

repositoryhttps://doi.org/10.1101/2024.01.15.575737

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38293195

Fields of Study

Parkinson's Disease Mechanisms and TreatmentsRNA regulation and diseaseNeurological disorders and treatments0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

CiliumLRRK2NeuroprotectionDopaminergicNeuroscienceBiologyCholinergic neuronStriatumParkinson's diseaseCholinergicMotile ciliumCiliary neurotrophic factorDopamineCell biologyNeurotrophic factorsInternal medicineMedicineDiseaseMaleDopaminergic Neurons610Hedgehog signalingParkinson DiseaseBiological SciencesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 kinaseArticleCorpus StriatumMiceprimary cilianame=General/dk/atira/pure/subjectarea/asjc/1000616MutationParkinson’s diseaseAnimalsHumansCiliaRab GTPase

Sustainable Development Goals

SDG 0: Good health and well-being

Data from: Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2driven and idiopathic Parkinson’s disease

10.5061/dryad.pk0p2ngvpDryad

Data from: Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2driven and idiopathic Parkinson's disease

10.5281/zenodo.10470950Zenodo

Data from: Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2driven and idiopathic Parkinson's disease

10.5281/zenodo.10470951Zenodo