FoxO6 regulates memory consolidation and synaptic function
FoxO6 regulates memory consolidation and synaptic function is a research paper published in Genes & Development (2012). On theSindex it has a DataRank of 4.9. It has been cited 139 times, with 133 citing works in its 1-hop citation network.
Abstract
The FoxO family of transcription factors is known to slow aging downstream from the insulin/IGF (insulin-like growth factor) signaling pathway. The most recently discovered FoxO isoform in mammals, FoxO6, is highly enriched in the adult hippocampus. However, the importance of FoxO factors in cognition is largely unknown. Here we generated mice lacking FoxO6 and found that these mice display normal learning but impaired memory consolidation in contextual fear conditioning and novel object recognition. Using stereotactic injection of viruses into the hippocampus of adult wild-type mice, we found that FoxO6 activity in the adult hippocampus is required for memory consolidation. Genome-wide approaches revealed that FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus. Consistently, FoxO6 deficiency results in decreased dendritic spine density in hippocampal neurons in vitro and in vivo. Thus, FoxO6 may promote memory consolidation by regulating a program coordinating neuronal connectivity in the hippocampus, which could have important implications for physiological and pathological age-dependent decline in memory.
›Data sources & pipeline
FAIR Checklist
Context only (not used in score)- Has DOI
- Open Access
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
DataRank Breakdown
Base Score Contribution
0.741
From this paper's citation signal
Citation Network Contribution
4.2
From 118 citing papers with measurable signal
Top 5 citers driving the network score
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
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- Exploration, normalization, and summaries of high density oligonucleotide array probe level dataBiostatistics200310,716 citationsDataRank 25.8Top 1%
- Significance analysis of microarrays applied to the ionizing radiation responseProceedings of the National Academy of Sciences200110,665 citationsDataRank 1.4
Why this DataRank?
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 15% comes from its base citations and 85% from the citation network (118 citing papers contributed measurable signal).
- Base score B(p)
- log1p(citation_count) — grows sub-linearly, so a paper with 1,000 citations is not 10× a paper with 100.
- Network N(p)
- Σ over citers of log1p(Cq) ÷ max(outdegreeq, 1). Being cited by a highly-cited paper with few references counts most.
- Damping factor d = 0.85
- DataRank = (1−d)·B(p) + d·N(p) — the two cards above are each already multiplied by their share.
- Self-citations excluded
- Citers sharing any OpenAlex author ID with this paper are filtered out before the network sum.
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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