Neuropeptide Y in Sympathetic Co‐Transmission: Recent Advances in the Search for Neuropeptide Y Antagonists is a research paper published in Pharmacology & Toxicology (1994). On theSindex it has a DataRank of 1.2. It has been cited 21 times, with 12 citing works in its 1-hop citation network.
Since the discovery of neuropeptide Y which is co‐stored and co‐operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non‐peptide antagonists have been proposed but they are mostly of low potency and non‐selective. Our recent observations that α‐trinositol (D‐myo‐inositol 1.2.6‐trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non‐peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down‐regulating neuropeptide Y receptors with antisense oligodeoxynucleotides is also discussed. Neuropeptide Y antagonistic agents would help us to understand the physiological role of neuropeptide Y and may serve as useful medication in circulation disorders.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.464
From this paper's citation signal
Citation Network Contribution
0.785
From 12 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 37% comes from its base citations and 63% from the citation network (12 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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