ArfGAP1 Activity and COPI Vesicle Biogenesis is a research paper published in Traffic (2009). On theSindex it has a DataRank of 1.9. It has been cited 55 times, with 39 citing works in its 1-hop citation network.
Golgi‐derived coat protein I (COPI) vesicles mediate transport in the early secretory pathway. The minimal machinery required for COPI vesicle formation from Golgi membranesin vitroconsists of (i) the hetero‐heptameric protein complex coatomer, (ii) the small guanosine triphosphatase ADP‐ribosylation factor 1 (Arf1) and (iii) transmembrane proteins that function as coat receptors, such as p24 proteins. Various and opposing reports exist on a role of ArfGAP1 in COPI vesicle biogenesis. In this study, we show that, in contrast to data in the literature, ArfGAP1 is not required for COPI vesicle formation. To investigate roles of ArfGAP1 in vesicle formation, we titrated the enzyme into a defined reconstitution assay to form and purify COPI vesicles. We find that catalytic amounts of Arf1GAP1 significantly reduce the yield of purified COPI vesicles and that Arf1 rather than ArfGAP1 constitutes a stoichiometric component of the COPI coat. Combining the controversial reports with the results presented in this study, we suggest a novel role for ArfGAP1 in membrane trafficking.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.604
From this paper's citation signal
Citation Network Contribution
1.3
From 36 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 31% comes from its base citations and 69% from the citation network (36 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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