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Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects

Drug Metabolism and Disposition(2020)10.1124/dmd.120.091041Source: DataRank Database

Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects is a research paper published in Drug Metabolism and Disposition (2020). On theSindex it has a DataRank of 0. It has been cited 17 times.

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Open Access17 citations

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Enrichment:Funding (1 grants)Impact (FWCI 1.44)OA: bronzeTopics (47)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Dandan Tian ORCID,Kenneth E. Thummel ORCID,Mary F. Paine ORCID,Allan E. Rettie ORCID,Matthew G. McDonald

Live enrichment

PubMed:32591416 PMC:PMC7543482 OpenAlex:https://openalex.org/W3038075533

NCCIH NIH HHS

Grant: U54 AT008909

FWCI

1.44

Citation Percentile

0.8%

Citation Trend

2020

2021

2022

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2025

bronzeLicense: https://www.elsevier.com/legal/tdmrep-license

journalhttps://dmd.aspetjournals.org/content/dmd/48/10/1018.full.pdf

publisherhttps://dmd.aspetjournals.org/content/dmd/48/10/1018.full.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0090955624078681?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0090955624078681?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1124/dmd.120.091041

Fields of Study

Berberine and alkaloids researchPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsAlkaloidsAllosteric RegulationArabidopsis ProteinsCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDrug Evaluation, PreclinicalDrug InteractionsHumansHydrastisInhibitory Concentration 50Microsomes, LiverNuclear ProteinsOxidation-ReductionPlant ExtractsPrescription Drugs

MeSH Terms

AlkaloidsAllosteric RegulationCytochrome P-450 Enzyme SystemDrug InteractionsDrug Evaluation, PreclinicalHumansMicrosomes, LiverNuclear ProteinsOxidation-ReductionPlant ExtractsInhibitory Concentration 50Arabidopsis ProteinsHydrastisPrescription DrugsCytochrome P-450 Enzyme Inhibitors

Keywords

Allosteric regulationBerberineChemistryStereochemistryHydroxylationCYP3A4IsoquinolineMicrosomeDextromethorphanCytochrome P450EnzymeBiochemistryPharmacologyBiology