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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

Molecular Pharmacology(2020)10.1124/mol.119.117556Source: DataRank Database

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils is a research paper published in Molecular Pharmacology (2020). On theSindex it has a DataRank of 0. It has been cited 24 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access24 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)Impact (FWCI 0.97)OA: bronzeTopics (27)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Naincy R. Chandan ORCID,Alan Y. Hsu ORCID,Prateek Sharma ORCID,Qing Deng ORCID,Alan V. Smrcka ORCID

Live enrichment

PubMed:31900312 PMC:PMC6994817 OpenAlex:https://openalex.org/W2997632522

NHLBI NIH HHS

Grant: R01 HL122416

NCI NIH HHS

Grant: R01 CA221289

NIGMS NIH HHS

Grant: R35 GM127303

NIGMS NIH HHS

Grant: R35 GM119787

NHLBI NIH HHS

Grant: R01 HL071818

FWCI

0.97

Citation Percentile

0.7%

Citation Trend

2019

2020

2021

2022

2023

2024

2025

2026

bronzeLicense: https://www.elsevier.com/legal/tdmrep-license

journalhttps://molpharm.aspetjournals.org/content/molpharm/97/3/226.full.pdf

BRONZEhttps://molpharm.aspetjournals.org/content/molpharm/97/3/226.full.pdf

publisherhttps://molpharm.aspetjournals.org/content/molpharm/97/3/226.full.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0026895X2400974X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0026895X2400974X?httpAccept=text/plain

Fields of Study

Protein Kinase Regulation and GTPase SignalingCell death mechanisms and regulationNeutrophil, Myeloperoxidase and Oxidative MechanismsChemistryMedicine

MeSH Terms

AnimalsBinding SitesCells, CulturedDose-Response Relationship, DrugHumansNeutrophilsZebrafishDrug Delivery SystemsProtein Structure, SecondaryProtein Structure, TertiaryPhosphatidylinositol PhosphatesCrystallography, X-RayGuanine Nucleotide Exchange FactorsDrug Discovery

Keywords

Pleckstrin homology domainGuanine nucleotide exchange factorPhosphatidylinositolChemistryBiochemistrySignal transductionBiologyCell biology

Sustainable Development Goals

SDG 0: Good health and well-being

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

FAIR Checklist

Authors (7)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)