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Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission

Science Advances(2024)10.1126/sciadv.adq1383Source: DataRank Database

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission is a research paper published in Science Advances (2024). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Enrichment:Funding (16 grants)OA: goldTopics (28)IDs (PubMed, PMC)Annotations (1)

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Authors (47)

Antima Gupta ORCID,Laura Drought ORCID,Avnish Patel ORCID,John Okombo ORCID,Mariëtte van der Watt ORCID

Live enrichment

PubMed:39642214 PMC:PMC11623267

Wellcome Trust

Grant: 106240/Z/14/Z

Wellcome Trust

Grant: 209367/Z/17/Z

Gates Foundation

Grant: INV-033538

NIAID NIH HHS

Grant: R01 AI139179

Wellcome Trust

Grant: 223849/Z/21/Z

NIAID NIH HHS

Grant: K08 AI163497

NIAID NIH HHS

Grant: R01 AI185559

Wellcome Trust

Grant: 106240

Functional analysis of the cGMP signalling pathway in malaria parasites: a master regulator of life cycle progression .

Wellcome Trust

Grant: 220318

Functional analysis of the downstream mediators of cyclic nucleotide signalling in malaria parasites

Wellcome Trust

Grant: 223849

Optimisation of lead compounds targeting malaria parasite phosphodiesterases

Wellcome Trust

Grant: 221363

Transmission facility for human malaria parasites

National Institutes of Health

Grant: 5K08AI163497-02

tRNA modification reprogramming in artemisinin-resistant Plasmodium falciparum: An epigenetic driver of resistance?

National Institutes of Health

Grant: 5R01AI185559-02

Defining the complex genetic basis of Plasmodium falciparum resistance to artemisinin and quinine and identifying resistance-refractory therapeutics

Wellcome Trust

Grant: 209367

Optimisation of phosphodiesterase inhibitors to provide in vivo proof of concept for development of a new antimalarial drug

National Institutes of Health

Grant: 5R01AI139179-07

Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipeline

Wellcome Trust

goldLicense: cc-by

publisherhttps://www.science.org/doi/pdf/10.1126/sciadv.adq1383?download=true

repositoryhttps://research.vu.nl/en/publications/28ab87e8-9f9d-4b07-ab72-c02d4f85534e

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11623267/pdf/sciadv.adq1383.pdf

repositoryhttps://hdl.handle.net/1871.1/28ab87e8-9f9d-4b07-ab72-c02d4f85534e

Europe_PMChttps://europepmc.org/articles/PMC11623267

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsHumansCulicidaePlasmodium falciparumMalaria, FalciparumPhosphoric Diester HydrolasesCyclic AMP-Dependent Protein KinasesProtozoan ProteinsPhosphodiesterase InhibitorsAntimalarialsLife Cycle Stages3',5'-Cyclic-AMP Phosphodiesterases

Keywords

Life Cycle StagesPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesPlasmodium falciparumProtozoan ProteinsCyclic AMP-Dependent Protein KinasesAntimalarialsCulicidae3',5'-Cyclic-AMP PhosphodiesterasesAnimalsHumansBiomedicine and Life SciencesMalaria, Falciparum