Lysosomal Proteins as a Therapeutic Target in Neurodegeneration is a research paper published in Annual Review of Medicine (2017). On theSindex it has a DataRank of 0.974. It has been cited 30 times, with 21 citing works in its 1-hop citation network.
Several proteins that are mutated in lysosomal storage diseases are linked to neurodegenerative disease. This review focuses on some of these lysosomal enzymes and transporters, as well as current therapies that have emerged from the lysosomal storage disease field. Given the deeper genetic understanding of lysosomal defects in neurodegeneration, we explore why some of these orphan disease drug candidates are also attractive targets in subpopulations of individuals with neurodegenerative disease.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.515
From this paper's citation signal
Citation Network Contribution
0.459
From 19 citing papers with measurable signal
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 53% comes from its base citations and 47% from the citation network (19 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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