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Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

Retrovirology(2021)10.1186/s12977-021-00575-zSource: DataRank Database

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators is a research paper published in Retrovirology (2021). On theSindex it has a DataRank of 0. It has been cited 6 times.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (14 grants)Impact (FWCI 0.41)OA: goldTopics (84)Linked Datasets (4)DataCite Reuse (4)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Accessible (1/2)

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Interoperable (2/2)

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Authors (8)

Andrew P. Holmes ORCID,Alexej Dick ORCID,Adel A. Rashad ORCID,Lucía Enríquez ORCID,Gabriela Canziani ORCID

Live enrichment

PubMed:34627310 PMC:PMC8501640 OpenAlex:https://openalex.org/W3205066747

national institute of allergy and infectious diseases

Grant: AI150471

national institute of allergy and infectious diseases

Grant: R01AI128815

national institute of allergy and infectious diseases

Grant: AI150490

national institute of general medical sciences

Grant: P01GM56550

national institute of general medical sciences

Grant: R01GM066682

NIH HHS

Grant: S10 OD027009

NIAID NIH HHS

Grant: P01 AI150471

NIAID NIH HHS

Grant: R01 AI150490

National Institutes of Health

Grant: 3P01GM056550-16S1

Structure-Based Antagonism of HIV-1 Envelope Function in Cell Entry

National Institutes of Health

Grant: 7R01AI150490-14

Mechanisms of HIV-1 Env-Mediated Membrane Fusion

National Institutes of Health

Grant: 5R01GM066682-05

HIV-1 Entry Inhibition by C-Peptide and 5-Helix Protein

National Institutes of Health

Grant: 5R01AI128815-02

Bifunctional Chimeras Targeting Both HIV-1 Env and Host Cell Co-receptors

National Institutes of Health

Grant: 5P01AI150471-26

Structure-Based Antagonism of HIV-1 Envelope Function in Cell Entry

National Institutes of Health

Grant: 5P41GM103311-36

Resource for Biocomputing Visualization and Informatics

FWCI

0.41

Citation Percentile

0.6%

Citation Trend

2022

2023

2025

2026

goldLicense: cc-by

journalhttps://retrovirology.biomedcentral.com/track/pdf/10.1186/s12977-021-00575-z

publisherhttps://retrovirology.biomedcentral.com/track/pdf/10.1186/s12977-021-00575-z

publisherhttps://link.springer.com/content/pdf/10.1186/s12977-021-00575-z.pdf

publisherhttps://link.springer.com/article/10.1186/s12977-021-00575-z/fulltext.html

journalhttps://doi.org/10.1186/s12977-021-00575-z

Fields of Study

HIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions0301 basic medicine03 medical and health sciences0303 health sciencesAnti-HIV AgentsBinding SitesDrug Resistance, ViralHIV Envelope Protein gp120HIV InfectionsHIV-1HumansMolecular Docking SimulationMutationPeptidesProtein ConformationTriazolesVirus Internalization

MeSH Terms

Binding SitesHumansMutationPeptidesProtein ConformationTriazolesHIV-1HIV InfectionsHIV Envelope Protein gp120Anti-HIV AgentsDrug Resistance, ViralVirus InternalizationMolecular Docking Simulation

Keywords

Gp41MutantPeptideChemistryDocking (animal)Steric effectsInfectivityResistance mutationPotencyPharmacophoreMolecular dynamicsIn vitroMolecular biologyBiochemistryStereochemistryBiologyVirologyVirusAntibodyGeneticsReverse transcriptaseRNAMedicineEpitopeGeneHIV-1Resistance mechanismConformational DynamicsSurface Plasmon Resonance (Spr)Entry InhibitorIsothermal Titration Calorimetry (Itc)Virus EscapeEnvelope GlycoproteinsMacrocyclic PeptideGp120 SheddingAnti-HIV AgentsProtein ConformationHIV InfectionsHIV Envelope Protein gp120https://purl.org/becyt/ford/1.6Drug Resistance, ViralHumanshttps://purl.org/becyt/ford/1Binding SitesResearchRC581-607TriazolesVirus InternalizationMolecular Docking SimulationMutationImmunologic diseases. AllergyPeptides

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

10.6084/m9.figshare.16779523.v1figshare

Additional file 1 of Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

10.6084/m9.figshare.16779523figshare

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

10.6084/m9.figshare.c.5655112figshare

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

10.6084/m9.figshare.c.5655112.v1figshare