The melanocortin system in leukocyte biology is a research paper published in Journal of Leukocyte Biology (2007). On theSindex it has a DataRank of 3.5. It has been cited 99 times, with 85 citing works in its 1-hop citation network.
AbstractThe melanocortin system is composed of the melanocortin peptides, adrenocorticotropic hormone and α-, β-, and γ-melanocyte-stimulating hormone, the melanocortin receptors (MCRs), and the endogenous antagonists agouti- and agouti-related protein. Melanocortin peptides exert multiple effects upon the host, including anti-inflammatory and immunomodulatory effects. Leukocytes are a source of melanocortins and a major target for these peptides. Because of reduced translocation of the nuclear factor NF-κB to the nucleus, MCR activation by their ligands causes a collective reduction of the most important molecules involved in the inflammatory process. This review examines how melanocortin peptides and their receptors participate in leukocyte biology.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.691
From this paper's citation signal
Citation Network Contribution
2.8
From 74 citing papers with measurable signal
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 20% comes from its base citations and 80% from the citation network (74 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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