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Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells

PLoS Computational Biology(2021)10.1371/journal.pcbi.1009125Source: DataRank Database

Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells is a research paper published in PLoS Computational Biology (2021). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Scored on demand from live citation data

Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 0.22)OA: goldTopics (70)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Adrian V. Lee ORCID,D. Lansing Taylor ORCID,Timothy R. Lezon ORCID,Cemal Erdem ORCID

Live enrichment

PubMed:34191793 PMC:PMC8277016 OpenAlex:https://openalex.org/W3174290516

National Institutes of Health

Grant: P30 CA047904

NCI NIH HHS

Grant: U01 CA204826

NCATS NIH HHS

Grant: UL1 TR001857

National Institutes of Health

Grant: 1UL1TR001857

National Institutes of Health

Grant: 3P30CA047904-07S1

CANCER CENTER SUPPORT GRANT

National Institutes of Health

Grant: 5U01CA204826-02

Informatics Tools for Tumor Heterogeneity in Multiplexed Fluorescence Images

National Institutes of Health

Grant: 3UL1TR001857-07S1

University of Pittsburgh Clinical and Translational Science Institute

FWCI

0.22

Citation Percentile

0.5%

Citation Trend

2022

2023

goldLicense: cc-by

journalhttps://doi.org/10.1371/journal.pcbi.1009125

publisherhttps://doi.org/10.1371/journal.pcbi.1009125

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34191793

repositoryhttp://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-218250

repositoryhttps://doaj.org/article/5a50932ee04e4320af6e668981cb0eb3

Fields of Study

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Phosphoinositide-3 Kinase InhibitorsBreast NeoplasmsComputer SimulationFemaleHumansInsulinInsulin-Like Growth Factor IModels, BiologicalReceptor, InsulinSignal TransductionAntigens, CDReceptor, IGF Type 1Computational BiologyGenes, BRCA1Phosphatidylinositol 3-KinasesRibosomal Protein S6 KinasesMAP Kinase Signaling SystemGenes, BRCA2Cell Line, TumorProto-Oncogene Proteins c-aktMCF-7 Cells

Keywords

Protein kinase BInsulin-like growth factor 1 receptorRibosomal s6 kinaseSignal transductionInsulin-like growth factorContext (archaeology)BiologyRibosomal protein s6Cell biologyStimulationInsulin receptorCancer researchGrowth factorReceptorInsulinEndocrinologyP70-S6 Kinase 1GeneticsInsulin resistanceQH301-705.5MAP Kinase Signaling SystemGenes, BRCA2Bioinformatics and Computational BiologyGenes, BRCA1Breast NeoplasmsModels, BiologicalReceptor, IGF Type 1Phosphatidylinositol 3-KinasesAntigens, CDCell Line, TumorHumansComputer SimulationBiology (General)Insulin-Like Growth Factor IPhosphoinositide-3 Kinase InhibitorsRibosomal Protein S6 KinasesComputational BiologyReceptor, InsulinBioinformatik och beräkningsbiologiMCF-7 CellsFemaleProto-Oncogene Proteins c-aktResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being