Posttranslational regulation of the GCN5 and PCAF acetyltransferases is a research paper published in PLOS Genetics (2022). On theSindex it has a DataRank of 0.582. It has been cited 11 times, with 11 citing works in its 1-hop citation network.
General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate. While decades of studies have uncovered a vast network of cellular processes impacted by these acetyltransferases, including gene transcription and metabolism, far less is known about how these enzymes are themselves regulated. In this review, we summarize the type and functions of posttranslational modifications proposed to control Gcn5 in both yeast and human cells. We further outline common themes, open questions, and strategies to guide future work.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.373
From this paper's citation signal
Citation Network Contribution
0.210
From 8 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 64% comes from its base citations and 36% from the citation network (8 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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