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Dual targeting of brain region‐specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1

The EMBO Journal(2021)10.15252/embj.2020106106Source: DataRank Database

Dual targeting of brain region‐specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1 is a research paper published in The EMBO Journal (2021). On theSindex it has a DataRank of 0.680. It has been cited 17 times, with 13 citing works in its 1-hop citation network.

N/A

0.680DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access17 citations · 13 citing works in its network

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Linked data & code

geo refseq

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE151276

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (22 grants)Impact (FWCI 1.25)OA: hybridTopics (67)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 64%Citation Network 36%

Base Score Contribution

0.434

From this paper's citation signal

Citation Network Contribution

0.247

From 11 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 13 citers.

A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 ( SCA22 ) by impairing ER and Golgi functioning
The Journal of Pathology20244 citations39 referencesContributes 0.041
pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients
Proceedings of the National Academy of Sciences20256 citations55 referencesContributes 0.035
Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex
Cells202210 citations69 referencesContributes 0.035
Dysregulation of alternative splicing in spinocerebellar ataxia type 1
Human Molecular Genetics20238 citations71 referencesContributes 0.031
The extra-cerebellar effects of spinocerebellar ataxia type 1 (SCA1): looking beyond the cerebellum
Cellular and Molecular Life Sciences202213 citations91 referencesContributes 0.029

Authors (20)

Laura A. Lavery ORCID,Maxime W.C. Rousseaux ORCID,Eric B Rutledge ORCID,Youjin Jang ORCID,Ying‐Wooi Wan ORCID

Live enrichment

PubMed:33709453 PMC:PMC8013850 OpenAlex:https://openalex.org/W3134278889

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: 2R37NS027699

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: R01‐NS045667‐17

Intellectual and Developmental Disabilities Research Center

Grant: 15P50HD103555

HHS | NIH | National Institute on Aging

Grant: R01AG057339

HHS | National Institutes of Health

Grant: R21NS096395

Parkinson's Foundation

Grant: JFA‐1762

HHS | NIH | National Institute of General Medical Sciences

Grant: R01GM120033

NIH/NCI

Grant: P30CA125123

Cancer Prevention and Research Institute of Texas

Grant: RP170005

NICHD NIH HHS

Grant: P50 HD103555

NINDS NIH HHS

Grant: R01 NS045667

NINDS NIH HHS

Grant: R37 NS027699

National Institutes of Health

Grant: 3P30CA125123-09S3

Baylor College of Medicine Cancer Center

National Institutes of Health

Grant: 5R37NS027699-30

MOLECULAR STUDIES OF SPINOCEREBELLAR ATAXIS TYPE I

National Institutes of Health

Grant: 5R21NS096395-02

Behavioral and cell-based complementary screens to identify druggable targets modulating tau protein levels

National Institutes of Health

Grant: 5R01NS045667-15

Cell Signaling and Neurodegeneration

National Institutes of Health

Grant: 3R01AG057339-04S1

Functional Dissection of Alzheimer's Disease Networks in Drosophila: from Association to Causal Modulators of Age-Dependent Neurodegeration

National Institutes of Health

Grant: 1P50HD103555-01

Baylor College of Medicine Intellectual and Developmental Disabilities Research Center

National Institutes of Health

Grant: 3R01GM120033-05S1

Advanced Computational Approaches for NMR Data-mining

Howard Hughes Medical Institute

Darrell K Royal Research Fund for Alzheimers Disease

Howard Hughes Medical Institute

FWCI

1.25

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: other-oa

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2020106106

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2020106106

publisherhttps://link.springer.com/content/pdf/10.15252/embj.2020106106.pdf

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.15252/embj.2020106106

publisherhttps://link.springer.com/article/10.15252/embj.2020106106/fulltext.html

Fields of Study

Genetic Neurodegenerative DiseasesMitochondrial Function and Pathology0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsAtaxin-1Brain StemCell Line, TumorCells, CulturedCerebellumDNA-Binding ProteinsDrosophila melanogasterHEK293 CellsHumansMicePhosphorylationProtein StabilityRibosomal Protein S6 Kinases, 90-kDaSpinocerebellar AtaxiasTranscription Factors

MeSH Terms

Ataxin-1AnimalsBrain StemCells, CulturedCerebellumDNA-Binding ProteinsDrosophila melanogasterHumansPhosphorylationTranscription FactorsSpinocerebellar AtaxiasRibosomal Protein S6 Kinases, 90-kDaCell Line, TumorMiceProtein StabilityHEK293 Cells

Keywords

BiologySpinocerebellar ataxiaProtein-Serine-Threonine KinasesKinaseDual (grammatical number)AtaxiaNeuroscienceDual roleGeneticsProtein kinase ASelective VulnerabilitySpinocerebellar Ataxia Type 1Msk1Ataxin-1Rsk3Protein StabilityRibosomal Protein S6 Kinases, 90-kDaDNA-Binding ProteinsMiceDrosophila melanogasterHEK293 CellsCell Line, TumorCerebellumAnimalsHumansSpinocerebellar AtaxiasPhosphorylationCells, CulturedBrain StemTranscription Factors

Sustainable Development Goals

SDG 0: Good health and well-being

Related Papers (2)

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

N/A

1.2DataRank · unranked

eLife(2022)

co-cited

10.7554/elife.75230

Updates to HCOP: the HGNC comparison of orthology predictions tool

Top 14%

1.4DataRank

Briefings in Bioinformatics(2021)

co-cited

10.1093/bib/bbab155

Dual targeting of brain region‐specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (20)

Funding (22 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)

Related Papers (2)