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DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation

EMBO Reports(2023)10.15252/embr.202255543Source: DataRank Database

DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation is a research paper published in EMBO Reports (2023). On theSindex it has a DataRank of 0.387. It has been cited 8 times, with 6 citing works in its 1-hop citation network.

N/A

0.387DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access8 citations · 6 citing works in its network

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Linked data & code

doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE221847

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 0.72)OA: greenTopics (54)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 85%Citation Network 15%

Base Score Contribution

0.330

From this paper's citation signal

Citation Network Contribution

0.0578

From 6 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 6 citers.

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Epigenetic regulation of human FOXP3+ Tregs: from homeostasis maintenance to pathogen defense
Frontiers in Immunology202443 citations231 referencesContributes 0.016
Deciphering the TET3 interactome in primary thymic developing T cells
iScience20249 citations143 referencesContributes 0.016
Targeting epigenetic regulators to boost T cell immunotherapy against cancer
Cell & Bioscience20261 citations130 referencesContributes 0.005
Targeting glutamine metabolism in CD4+ T‐cell‐mediated autoimmune diseases
Immunology and Cell Biology20251 citations131 referencesContributes 0.005

Authors (11)

Kara Misel‐Wuchter ORCID,Jace Heath ORCID,Andrew L. Thurman ORCID,Priyanjali Pulipati ORCID,Garima Dixit ORCID

Live enrichment

PubMed:36880575 PMC:PMC10157375 OpenAlex:https://openalex.org/W4323347899

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: HL163556

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: HL152960

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: T32 AI007511

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: T32AI007485

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK124207

UI | Holden Comprehensive Cancer Center, University of Iowa

Grant: HL091842

NHLBI NIH HHS

Grant: P01 HL152960

NIDDK NIH HHS

Grant: RC2 DK124207

NHLBI NIH HHS

Grant: P01 HL091842

NHLBI NIH HHS

Grant: R01 HL163024

NHLBI NIH HHS

Grant: R01 HL163556

NHLBI NIH HHS

Grant: K01 HL140261

National Institutes of Health

Grant: 5T32AI007511-08

Training in Mechanisms of Parasitism

National Institutes of Health

Grant: 5RC2DK124207-02

Early Pathogenesis of Cystic Fibrosis Related Diabetes

National Institutes of Health

Grant: 5P01HL091842-14

Origins of Cystic Fibrosis Airway Disease

National Institutes of Health

Grant: 5T32AI007485-14

Predoctoral Training Program in Immunology

National Institutes of Health

Grant: 5P01HL152960-02

Molecular Therapies for Cystic Fibrosis Lung Disease

National Institutes of Health

Grant: 1ZIADK013039-04

Molecular modeling of soluble proteins

National Institutes of Health

Grant: 5R01HL163556-02

Testing the Contributions of Airway Submucosal Glands and Surface Epithelia to Lung Health

FWCI

0.72

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

2026

greenLicense: cc-by-nc-nd

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10157375/pdf/EMBR-24-e55543.pdf

publisherhttps://link.springer.com/content/pdf/10.15252/embr.202255543.pdf

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.15252/embr.202255543

publisherhttps://link.springer.com/article/10.15252/embr.202255543/fulltext.html

Fields of Study

T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and InteractionHumansMiceAnimalsInterleukin-2DNA DemethylationThymus GlandT-Lymphocytes, RegulatoryReceptors, Antigen, T-CellCell DifferentiationForkhead Transcription Factors

MeSH Terms

DNA DemethylationAnimalsCell DifferentiationHumansInterleukin-2Receptors, Antigen, T-CellThymus GlandT-Lymphocytes, RegulatoryMiceForkhead Transcription Factors

Keywords

FOXP3BiologyT-cell receptorCell biologyIL-2 receptorAutocrine signallingDNA demethylationTranscription factorCellular differentiationT cellParacrine signallingChromatinImmunologyDNA methylationReceptorGene expressionGeneGeneticsIL-2Treg DevelopmentTet EnzymesMiceReceptors, Antigen, T-CellHumansAnimalsInterleukin-2Cell DifferentiationForkhead Transcription FactorsThymus GlandT-Lymphocytes, RegulatoryReports

Sustainable Development Goals

SDG 0: Good health and well-being