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Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin

Frontiers in Cellular and Infection Microbiology(2020)10.3389/fcimb.2020.00066Source: DataRank Database

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin is a research paper published in Frontiers in Cellular and Infection Microbiology (2020). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (12 grants)Impact (FWCI 0.49)OA: goldTopics (114)IDs (PubMed, PMC, OpenAlex)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Roman Leontovyč ORCID,Tomáš Macháček ORCID,Anthony J. O’Donoghue ORCID,Ondřej Šedo ORCID,Zbyněk Zdráhal ORCID

Live enrichment

PubMed:32175287 PMC:PMC7054455 OpenAlex:https://openalex.org/W3008859878

Univerzita Karlova v Praze

Grant: PROGRES Q43

Univerzita Karlova v Praze

Grant: UNCE/SCI/012 - 204072/2018

Ministerstvo Å kolstvÃ, MlÃ¡deÅ¾e a TÄ›llovÃ½chovy

Grant: LM2015042

Ministerstvo Å kolstvÃ, MlÃ¡deÅ¾e a TÄ›llovÃ½chovy

Grant: LM2015043

Ministerstvo Å kolstvÃ, MlÃ¡deÅ¾e a TÄ›llovÃ½chovy

Grant: LQ1601

National Institutes of Health

Grant: P50 GM082250

NIGMS NIH HHS

Grant: R01 GM104659

NIAID NIH HHS

Grant: P50 AI150476

National Institutes of Health

Grant: 5P50AI150476-14

HARC Center: HIV Accessory and Regulatory Complexes

National Institutes of Health

Grant: 4R01GM104659-04

Allosteric Inhibition of a Family of Proteolytic Enzymes

European Regional Development Fund

GrantovÃ¡ AgenturaÄŒeskÃ©Republiky

FWCI

0.49

Citation Percentile

0.6%

Citation Trend

2020

2023

2024

goldLicense: cc-by

journalhttps://doi.org/10.3389/fcimb.2020.00066

publisherhttps://doi.org/10.3389/fcimb.2020.00066

publisherhttps://www.frontiersin.org/article/10.3389/fcimb.2020.00066/full

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32175287

repositoryhttps://doaj.org/article/6a312c927f794025831e214f8b7b7f3c

Fields of Study

Parasites and Host InteractionsVitamin K Research StudiesParasite Biology and Host Interactions0301 basic medicine0303 health sciences03 medical and health sciencesAmino Acid SubstitutionAnimalsAstrocytesCathepsin BCell SurvivalCystatinsEnzyme PrecursorsHydrolysisIsoenzymesMacrophagesMiceNitric OxideProtein BindingProteolysisRAW 264.7 CellsRecombinant ProteinsSchistosomatidaeSubstrate Specificity

MeSH Terms

RAW 264.7 CellsAnimalsAstrocytesCathepsin BCell SurvivalEnzyme PrecursorsHydrolysisIsoenzymesMacrophagesNitric OxideProtein BindingRecombinant ProteinsSchistosomatidaeSubstrate SpecificityCystatinsAmino Acid SubstitutionMiceProteolysis

Keywords

Gene isoformExopeptidaseBiologyBiochemistryCathepsin LEndopeptidaseCystatinEnzymeActive siteMolecular biologyCathepsin CCathepsin DCathepsinGeneSubstrate specificityCathepsin BHelminthSchistosomePeptidaseprocessingOccluding LoopCell Survival (mesh)Cystatins (mesh)MiceAmino Acid Substitution (mesh)Cathepsin B (mesh)Cellular and Infection Microbiology0605 Microbiology (for)SchistosomatidaeAstrocytes (mesh)Protein Binding (mesh)Animals (mesh)Hydrolysis (mesh)Enzyme Precursors3107 Microbiology (for-2020)HydrolysisMice (mesh)Biological SciencesMedical microbiologyQR1-502Recombinant ProteinsIsoenzymesProteolysis (mesh)Substrate Specificity (mesh)Protein BindingIsoenzymes (mesh)570RAW 264.7 Cells (mesh)Cell Survival1.1 Normal biological development and functioning0601 Biochemistry and Cell Biology (for)Enzyme Precursors (mesh)Nitric OxideMicrobiologyGeneticsRecombinant Proteins (mesh)AnimalsSchistosomatidae (mesh)1.1 Normal biological development and functioning (hrcs-rac)31 Biological Sciences (for-2020)Genetics (rcdc)Macrophages3207 Medical microbiology (for-2020)Cystatins3101 Biochemistry and Cell Biology (for-2020)RAW 264.7 CellsAmino Acid SubstitutionAstrocytesMacrophages (mesh)Nitric Oxide (mesh)ProteolysisBiochemistry and Cell Biology