Anthony J. O’Donoghue

MedicineComputer ScienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 62 papers. Top paper: “A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding”.

A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding

Science(2020)10.1126/science.abb7709

N/A

4.2DataRank · unranked

235 citations

Lu Zhao, Rui Chen, Chenxi Liu, Anthony J. O’Donoghue, Conor R. Caffrey +3 more

Development of Potent and Highly Selective Epoxyketone‐Based Plasmodium Proteasome Inhibitors

Chemistry - A European Journal(2023)10.1002/chem.202203958

N/A

0.620DataRank · unranked

25 citations

Pavla Fajtová, Jaeson Calla, Gregory LaMonte, Mudong Feng, Frances Rocamora +10 more

Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

Nature Communications(2022)10.1038/s41467-022-32016-6

N/A

0.581DataRank · unranked

47 citations

Allegra T. Aron, Pavla Fajtová, Paolo Stincone, Berenike Wagner, Alicia Isabel Pérez‐Lorente +23 more

Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity

ACS Sensors(2021)10.1021/acssensors.1c00518

N/A

0.557DataRank · unranked

40 citations

Raina M. Borum, Yash Mantri, Ming Xu, Pavla Fajtová, Anthony J. O’Donoghue +2 more

Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing

Angewandte Chemie International Edition(2022)10.1002/anie.202214394

N/A

0.524DataRank · unranked

32 citations

Yi Li, Ke Li, Jiajing Zhou, Justin Yeung, Chuxuan Ling +13 more

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing

ACS Chemical Neuroscience(2021)10.1021/acschemneuro.1c00133

N/A

0.483DataRank · unranked

24 citations

Christopher B. Lietz, Sonia Podvin, Michael C. Yoon, Thomas Toneff, Vivian Hook +2 more

Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing

Angewandte Chemie(2022)10.1002/ange.202214394

N/A

0.473DataRank · unranked

11 citations

Yi Li, Ke Li, Jiajing Zhou, Justin Yeung, Chuxuan Ling +13 more

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

Nature Communications(2024)10.1038/s41467-024-53022-w

N/A

0.454DataRank · unranked

11 citations

Pavla Fajtová, Jitka Bartošová, Brianna M. Hurysz, Jehad Almaliti, Yukiko Miyamoto +5 more

Endoproteolysis of Oligopeptide-Based Coacervates for Enzymatic Modeling

ACS Nano(2023)10.1021/acsnano.3c04259

N/A

0.434DataRank · unranked

17 citations

Chuxuan Ling, Wonjun Yim, Yu‐Ci Chang, Tengyu He, Ke Li +11 more

A single-cell RNAseq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.03.932004

N/A

0.406DataRank · unranked

14 citations

Lu Zhao, Rui Chen, Chenxi Liu, Anthony J. O’Donoghue, Conor R. Caffrey +2 more

Peptide valence-induced breaks in plasmonic coupling

Chemical Science(2023)10.1039/d2sc05837e

N/A

0.385DataRank · unranked

12 citations

Zhicheng Jin, Ke Li, Jiajing Zhou, Wonjun Yim, Justin Yeung +9 more

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.05.498881

N/A

0.360DataRank · unranked

10 citations

Conner Bardine, Stefan Gahbauer, Isha Singh, Kris M. White, Shuo Gu +19 more

Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions

ACS Omega(2022)10.1021/acsomega.2c02287

N/A

0.345DataRank · unranked

9 citations

Charles Mosier, Michael C. Yoon, Evgenia Glukhov, Conor R. Caffrey, Anthony J. O’Donoghue +3 more

An approach to zwitterionic peptide design for colorimetric detection of the Southampton norovirus SV3CP protease

The Analyst(2023)10.1039/d3an00873h

N/A

0.292DataRank · unranked

6 citations

Zhicheng Jin, Chuxuan Ling, Maurice Retout, Elany Barbosa da Silva, Manan Damani +5 more

A GMR enzymatic assay for quantifying nuclease and peptidase activity

Frontiers in Bioengineering and Biotechnology(2024)10.3389/fbioe.2024.1363186

N/A

0.269DataRank · unranked

5 citations

Ana K. Serrano, Joshua V. Rosenberg, Douglas Conrad, Drew A. Hall, Anthony J. O’Donoghue +1 more

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin

Frontiers in Cellular and Infection Microbiology(2020)10.3389/fcimb.2020.00066

N/A

0.241DataRank · unranked

4 citations

Roman Leontovyč, Tomáš Macháček, Anthony J. O’Donoghue, Ondřej Šedo, Zbyněk Zdráhal +5 more

Role of Inflammasome-independent Activation of IL-1β by the Pseudomonas aeruginosa Protease LasB

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.18.101303

N/A

0.241DataRank · unranked

4 citations

Doris L. LaRock, Elaine A. Skowronski, Jacqueline M. Kimmey, Joshua Olson, Zhenze Jiang +4 more

A multiplex method for rapidly identifying viral protease inhibitors

Molecular Systems Biology(2025)10.1038/s44320-024-00082-1

N/A

0.239DataRank · unranked

3 citations

Samuel J. Resnick, Sho Iketani, Ji Won Cha, Benjamin Alexander Albert, Christopher T. Fazekas +19 more

A recombinant expression system for the Plasmodium falciparum proteasome enables structural analysis of its assembly and the design of selective inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.13.670186

N/A

0.208DataRank · unranked

3 citations

Hanxiao Zhang, Liam Urich, Elany Barbosa da Silva, Cesar Hoffmann da Silva, Jehad Almaliti +10 more

Allergen Content and Protease Activity in Milk Feeds from Mothers of Preterm Infants

Breastfeeding Medicine(2022)10.1089/bfm.2022.0115

N/A

0.146DataRank · unranked

1 citations

Diba Mortazavi, Sherry Bai-Tong, Kerri Bertrand, Christina Chambers, Keriann Schulkers-Escalante +8 more

Development of subunit selective substrates for Trichomonas vaginalis proteasome

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.05.535794

N/A

0DataRank · unranked

4 citations

Brianna M. Hurysz, Yukiko Miyamoto, Mateus Sá Magalhães Serafim, Zhenze Jiang, Diego F. Trujillo +11 more

Small Molecule in situ Resin Capture – A Compound First Approach to Natural Product Discovery

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.02.530684

N/A

0DataRank · unranked

2 citations

Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke +7 more

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.17.553660

N/A

0DataRank · unranked

2 citations

Pavla Fajtová, Jitka Bartošová, Brianna M. Hurysz, Jehad Almaliti, Yukiko Miyamoto +5 more

Small molecule in situ resin capture provides a compound first approach to natural product discovery

Nature Communications(2024)10.1038/s41467-024-49367-x

N/A

0DataRank · unranked

25 citations

Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke +7 more

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (S, Se) and Their Azole Derivatives against Chagas Disease

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01535

N/A

0DataRank · unranked

9 citations

Verónica Alcolea, Elany Barbosa da Silva, Miriam A. Giardini, Thaís Helena Maciel Fernandes, Nuria Martínez‐Sáez +4 more

Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome

Protein Science(2024)10.1002/pro.5225

N/A

0DataRank · unranked

8 citations

Brianna M. Hurysz, Yukiko Miyamoto, Mateus Sá Magalhães Serafim, Zhenze Jiang, Julia M. Vazquez +13 more

Evaluating Antimalarial Proteasome Inhibitors for Efficacy in Babesia Blood Stage Cultures

ACS Omega(2024)10.1021/acsomega.4c04564

N/A

0DataRank · unranked

6 citations

Pavla Fajtová, Pavla Šnebergerová, Marie Jalovecká, V. A. Levytska, Elany Barbosa da Silva +9 more

The proteasome as a drug target for treatment of parasitic diseases

Advances in Parasitology/Advances in parasitology(2024)10.1016/bs.apar.2024.04.001

N/A

0DataRank · unranked

4 citations

Anthony J. O’Donoghue, Conor R. Caffrey, Lawrence J. Liu

Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis

PLoS ONE(2024)10.1371/journal.pone.0308672

N/A

0DataRank · unranked

1 citations

Yukiko Miyamoto, Brianna M. Hurysz, Anthony J. O’Donoghue, Lars Eckmann, Noelle M Nieskens

Structure elucidation, biosynthetic gene cluster distribution, and biological activities of ketomemicin analogs in Salinispora

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.29.620863

N/A

0DataRank · unranked

0 citations

Dulce G. Guillén Matus, Elany Barbosa da Silva, Wentao Guo, Alicia Ross, Mateus Sá Magalhães Serafim +5 more

Comprehensive proteolytic profiling of Aedes aegypti mosquito midgut extracts: Unraveling the blood meal protein digestion system

PLoS neglected tropical diseases(2025)10.1371/journal.pntd.0012555

N/A

0DataRank · unranked

9 citations

Chenxi Liu, Carter J. Simington, Saira Montermoso, Elizabeth Moreno-Galvez, Mateus Sá Magalhães Serafim +14 more

Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01520

N/A

0DataRank · unranked

4 citations

Jyoti Vishwakarma, Katharina Sylvester, Nobuyo Higashi‐Kuwata, Agnieszka Dąbrowska, Renee Delgado +16 more

The impact of pH on proteolytic activity in wound fluid: Implications for acid therapy

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110723

N/A

0DataRank · unranked

3 citations

Meredith J. Crane, Lawrence Liu, Danielle Gelsinger, Alexander R. D. Jordon, Phuong Le +7 more

Development of Macrocyclic Peptide-Based Proteasome Inhibitors with Enhanced Blood-Brain Barrier Penetration for Treating Brain Neoplasms

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00544

N/A

0DataRank · unranked

2 citations

Momen Al-Hindy, Pavla Fajtová, Evgenia Glukhov, Theodore W. Berger, Yan Graf +7 more

Repurposing Diflunisal as an Antivirulence Agent Against Staphylococcus aureus

Infectious Microbes & Diseases(2025)10.1097/im9.0000000000000174

N/A

0DataRank · unranked

4 citations

Nina M. Haste, Josh Sun, Mateus Sá Magalhães Serafim, Anna Salvioni, Joshua Olson +8 more

Neutral pH-Selective Inhibition of Cytosolic Cathepsin B: A Novel Drug Targeting Strategy for Traumatic Brain Injury and Alzheimer’s Disease

ACS Chemical Biology(2025)10.1021/acschembio.5c00463

N/A

0DataRank · unranked

3 citations

Sonia Podvin, Michael C. Yoon, Von V. Phan, Jazmin Florio, Brian Spencer +8 more

An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108275

N/A

0DataRank · unranked

2 citations

Mac Kevin E. Braza, Stancho Stanchev, Marina Tauber, Raghad Al-Bawab, Lawrence J. Liu +10 more

Inhibitors of the 20S proteasome β5 subunit as potent and selective agents against Trichomonas vaginalis

Antimicrobial Agents and Chemotherapy(2025)10.1128/aac.00893-25

N/A

0DataRank · unranked

1 citations

Brianna M. Hurysz, Pavla Fajtová, Peter Eckmann, Mateus Sá Magalhães Serafim, Thales Kronenberger +10 more

Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of Ketomemicin Analogs in Salinispora

Marine Drugs(2025)10.3390/md23030126

N/A

0DataRank · unranked

1 citations

Dulce G. Guillén Matus, Elany Barbosa da Silva, Wentao Guo, Alicia Ross, Mateus Sá Magalhães Serafim +5 more

mspms : A Comprehensive R Package and Graphic Interface for Multiplex Substrate Profiling by Mass Spectrometry Analysis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.14.648679

N/A

0DataRank · unranked

0 citations

Brianna M. Hurysz, David J. Gonzalez, Anthony J. O’Donoghue, Charlie Bayne

Chalcogen Derivatives for the Treatment of African Trypanosomiasis: Biological Evaluation of Thio- and Seleno-Semicarbazones and Their Azole Derivatives

ACS Omega(2025)10.1021/acsomega.5c02014

N/A

0DataRank · unranked

0 citations

Thaiz R. Teixeira, Tina P. Nguyen, Mai Shingyoji, Elany Barbosa da Silva, Anthony J. O’Donoghue +4 more

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics(2020)10.1016/j.bbapap.2020.140428

N/A

0DataRank · unranked

170 citations

Michael C. Yoon, Charles Mosier, Gen Ito, Sonia Podvin, Brian P. Head +4 more

Substrate profiling of marine-derived thermotolerant cysteine protease reveals unique cleavage preferences for industrial applications

Scientific Reports(2025)10.1038/s41598-025-11635-1

N/A

0DataRank · unranked

0 citations

Brianna M. Hurysz, Hasan Arsın, Julia M. Vazquez, Anna‐Karina Kaczorowska, Anita‐Elin Fedöy +7 more

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

EBioMedicine(2020)10.1016/j.ebiom.2020.102984

N/A

0DataRank · unranked

59 citations

Doris L. LaRock, Elaine A. Skowronski, Jacqueline M. Kimmey, Joshua Olson, Zhenze Jiang +3 more

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

Molecules(2020)10.3390/molecules25184071

N/A

0DataRank · unranked

21 citations

Zhenze Jiang, Simona Nonnis, Armando Negri, Valentina Romeo, Christopher B. Lietz +8 more

Giant magnetoresistive biosensors for real-time quantitative detection of protease activity

Scientific Reports(2020)10.1038/s41598-020-62910-2

N/A

0DataRank · unranked

45 citations

Sonal Jain, Michael Sveiven, Xiahan Zhou, Anthony J. O’Donoghue, Drew A. Hall +1 more

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses

Molecular & Cellular Proteomics(2020)10.1074/mcp.ra120.002079

N/A

0DataRank · unranked

44 citations

Alexander C. Jones, Qing Liu, Brent Aulston, Linnea Ransom, Janneca Ames +10 more

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.23.347534

N/A

0DataRank · unranked

17 citations

Chien‐Te K. Tseng, Aleksandra Drelich, Pavla Fajtová, Balachandra Chenna, Demetrios H. Kostomiris +24 more

Giant magnetoresistive biosensors for real-time quantitative detection of protease activity

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.26.917476

N/A

0DataRank · unranked

1 citations

Sonal Jain, Michael Sveiven, Xiahan Zhou, Anthony J. O’Donoghue, Drew A. Hall +1 more

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2108728118

N/A

0DataRank · unranked

120 citations

Vishnu C. Damalanka, Michael A. Tartell, Dong hee Chung, André Luiz Lourenço, Dustin Pwee +18 more

Native Metabolomics Identifies the Rivulariapeptolide Family of Protease Inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.03.458897

N/A

0DataRank · unranked

8 citations

Allegra T. Aron, Pavla Fajtová, Paolo Stincone, Chenxi Liu, Ido Ben‐Shalom +12 more

Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer’s Disease Brain

ACS Chemical Neuroscience(2022)10.1021/acschemneuro.2c00222

N/A

0DataRank · unranked

38 citations

Zhenze Jiang, Ben Boyarko, Leigh‐Ana Rossitto, Anthony J. O’Donoghue, Robert A. Rissman +2 more

Peptidic Sulfhydryl for Interfacing Nanocrystals and Subsequent Sensing of SARS-CoV-2 Protease

Chemistry of Materials(2022)10.1021/acs.chemmater.1c03871

N/A

0DataRank · unranked

19 citations

Justin Yeung, Jiajing Zhou, Yong Cheng, Yi Li, Yash Mantri +12 more

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

Pharmaceuticals(2022)10.3390/ph15060744

N/A

0DataRank · unranked

15 citations

Jacob Kattoula, Julius Y. Kattoula, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini +6 more

A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease

Analytical Chemistry(2022)10.1021/acs.analchem.2c02381

N/A

0DataRank · unranked

10 citations

Jiajing Zhou, Yong Cheng, Zhicheng Jin, Alex E. Clark, Tengyu He +10 more

Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases

ACS Chemical Neuroscience(2022)10.1021/acschemneuro.1c00653

N/A

0DataRank · unranked

8 citations

Janneca Ames, Charles Mosier, Zhenze Jiang, Sonia Podvin, Anthony J. O’Donoghue +2 more

Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.25.501481

N/A

0DataRank · unranked

0 citations

Taylor H. Nguyen, Lawrence Liu, Markus Lakemeyer, Danielle J. Gelsinger, Rachael B. Chanin +10 more

Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

Research Square(2022)10.21203/rs.3.rs-1918112/v1

N/A

0DataRank · unranked

0 citations

Taylor H. Nguyen, Lawrence Liu, Markus Lakemeyer, Danielle Gelsinger, Rachel Chanin +10 more

Large library docking for novel SARS‐CoV ‐2 main protease non‐covalent and covalent inhibitors

Protein Science(2023)10.1002/pro.4712

N/A

0DataRank · unranked

43 citations

Conner Bardine, Stefan Gahbauer, Isha Singh, Tyler C. Detomasi, Kris M. White +26 more

Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome

Cell chemical biology(2023)10.1016/j.chembiol.2023.03.002

N/A

0DataRank · unranked

29 citations

Barbara H. Stokes, Kurt E. Ward, Kate J. Fairhurst, Charisse Flerida A. Pasaje, Tomas Yeo +21 more

A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of Porphyromonas gingivalis Enzymatic Activity

ACS Nano(2023)10.1021/acsnano.3c05268

N/A

0DataRank · unranked

28 citations

Lubna Amer, Wonjun Yim, Matthew N. Creyer, Benjamin Lam, Diego F. Trujillo +5 more

Empirical Optimization of Peptide Sequence and Nanoparticle Colloidal Stability: The Impact of Surface Ligands and Implications for Colorimetric Sensing

ACS Applied Materials & Interfaces(2023)10.1021/acsami.3c00862

N/A

0DataRank · unranked

23 citations

Justin Yeung, Jiajing Zhou, Maurice Retout, Wonjun Yim, Pavla Fajtová +7 more