Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Bile Acids Are Potential Negative Allosteric Modulators of M1 Muscarinic Receptors

Biomolecules(2025)10.3390/biom15091326Source: DataRank Database

Bile Acids Are Potential Negative Allosteric Modulators of M1 Muscarinic Receptors is a research paper published in Biomolecules (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access1 citations

Download PDF

Cite:

Linked data & code

pdb doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 0.46)OA: goldTopics (45)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (4)

Alexander D. MacKerell ORCID,David J. Weber ORCID,Jean‐Pierre Raufman ORCID,Wenbo Yu ORCID

Live enrichment

PubMed:41008633 PMC:PMC12467027 OpenAlex:https://openalex.org/W4414288292

United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development Program

Grant: BX004890

United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development Program

Grant: R01 GM129327

United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development Program

Grant: R35 GM131710

BLRD VA

Grant: I01 BX004890

NIH HHS

Grant: 5R35GM131710-07

NIH HHS

Grant: 5R01GM129327-04

National Institutes of Health

Grant: 5R01GM129327-03

Signal Propagation in Protein Allostery: Mechanism and Evolution

National Institutes of Health

Grant: 5R35GM131710-02

Macromolecular Conformational Heterogeneity

FWCI

0.46

Citation Percentile

0.7%

Citation Trend

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/2218-273X/15/9/1326/pdf?version=1758101481

publisherhttps://www.mdpi.com/2218-273X/15/9/1326/pdf?version=1758101481

publisherhttps://www.mdpi.com/2218-273X/15/9/1326/pdf

journalhttps://doi.org/10.3390/biom15091326

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41008633

Fields of Study

Drug Transport and Resistance MechanismsReceptor Mechanisms and SignalingSphingolipid Metabolism and Signaling0301 basic medicine03 medical and health sciencesBile Acids and SaltsAllosteric RegulationHumansMolecular Dynamics SimulationReceptor, Muscarinic M1Binding SitesProtein BindingAllosteric Site

MeSH Terms

Allosteric RegulationAllosteric SiteBile Acids and SaltsBinding SitesHumansProtein BindingReceptor, Muscarinic M1Molecular Dynamics Simulation

Keywords

Allosteric regulationG protein-coupled bile acid receptorBile acidReceptorMuscarinic acetylcholine receptorAmino acidNuclear receptorCholic acidAllosteric modulatorMolecular dynamicsmuscarinic receptorsBile acidsDockingCholinergic SignalingAllosteric BindingSite Identification By Ligand Competitive SaturationBile Acids and SaltsBinding SitesReceptor, Muscarinic M1HumansMolecular Dynamics SimulationArticleAllosteric SiteProtein Binding

Bile Acids Are Potential Negative Allosteric Modulators of M1 Muscarinic Receptors

FAIR Checklist

Authors (4)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)