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Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7

International Journal of Molecular Sciences(2021)10.3390/ijms22115831Source: DataRank Database

Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7 is a research paper published in International Journal of Molecular Sciences (2021). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)Impact (FWCI 1.52)OA: goldTopics (78)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (1)

Irina F. Sevrioukova ORCID

Live enrichment

PubMed:34072457 PMC:PMC8198134 OpenAlex:https://openalex.org/W3165607528

National Institutes of Health

Grant: ES025767

NIGMS NIH HHS

Grant: P30 GM133894

NIEHS NIH HHS

Grant: R01 ES025767

National Institutes of Health

Grant: 5R01ES025767-08

Toxicological importance of CYP3A4 catalysis and inhibition

National Institutes of Health

Grant: 3P30GM133894-06S1

A Synchrotron Radiation Structural Biology Resource

FWCI

1.52

Citation Percentile

0.8%

Citation Trend

2022

2023

2025

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/22/11/5831/pdf?version=1622537566

publisherhttps://www.mdpi.com/1422-0067/22/11/5831/pdf?version=1622537566

publisherhttps://www.mdpi.com/1422-0067/22/11/5831/pdf

journalhttps://doi.org/10.3390/ijms22115831

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34072457

Fields of Study

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsMetabolism and Genetic Disorders0301 basic medicine03 medical and health sciences0303 health sciencesAmino Acid SequenceAmino AcidsBinding SitesCatalysisCatalytic DomainCytochrome P-450 CYP3AHumansLigandsMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureMutationPolymorphism, GeneticProtein BindingStructure-Activity RelationshipSubstrate Specificity

MeSH Terms

Amino Acid SequenceAmino AcidsBinding SitesCatalysisHumansLigandsMolecular ConformationMutationPolymorphism, GeneticProtein BindingStructure-Activity RelationshipSubstrate SpecificityMolecular StructureCatalytic DomainCytochrome P-450 CYP3AMolecular Dynamics SimulationMolecular Docking Simulation

Keywords

ChemistryHemeLigand (biochemistry)Active siteBiophysicsBiochemistryEnzymeStereochemistryBiologyReceptorProtein conformationCrystal structureCytochrome p450Surface MutantCyp3a7Protein Plasticity570Molecular ConformationMolecular Dynamics SimulationLigandsArticleCatalysisSubstrate SpecificityStructure-Activity RelationshipGeneticCatalytic DomainCytochrome P-450 CYP3AHumansAmino Acid SequencePolymorphismAmino AcidsBinding SitesPolymorphism, GeneticMolecular Structure540Molecular Docking SimulationMutationProtein Binding

Sustainable Development Goals

SDG 13: 13. Climate action

Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7

FAIR Checklist

Authors (1)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)