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Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

eLife(2021)10.7554/elife.59067Source: DataRank Database

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development is a research paper published in eLife (2021). On theSindex it has a DataRank of 0.889. It has been cited 27 times, with 22 citing works in its 1-hop citation network.

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0.889DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access27 citations · 22 citing works in its network

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Linked data & code

geo cellosaurus gen refsnp uniprot doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE149148 GSE115327 GSE51311 GSE54471 GSE16256 GSE16368 GSE17312 GSE18927

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)OA: goldTopics (73)IDs (PubMed, PMC)Annotations (6)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 56%Citation Network 44%

Base Score Contribution

0.500

From this paper's citation signal

Citation Network Contribution

0.389

From 16 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 22 citers.

Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism
Nature Genetics202267 citations50 referencesContributes 0.084
TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation
Nature Communications202237 citations69 referencesContributes 0.053
TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling
Stem Cell Reports20249 citations60 referencesContributes 0.038
Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster
Developmental Cell202225 citations86 referencesContributes 0.038
Enhancer grammar in development, evolution, and disease: dependencies and interplay
Developmental Cell2021173 citations142 referencesContributes 0.036

Authors (14)

Allen Wang ORCID,Joshua Chiou ORCID,Joseph J. Lancman,Nichole Wetton,Samy Kefalopoulou ORCID

Live enrichment

PubMed:33544077 PMC:PMC7864636

NIDDK NIH HHS

Grant: R01 DK064391

NIDDK NIH HHS

Grant: R01 DK068471

NIGMS NIH HHS

Grant: T32 GM008666

NIDDK NIH HHS

Grant: U01 DK105541

National Institutes of Health

Grant: P30 DK064391

National Institutes of Health

Grant: 1DP2DK098092

NIDDK NIH HHS

Grant: DP2 DK098092

Diabetes Research Connection

Grant: Project #08

W.M. Keck Foundation

Grant: 2017-01

National Institutes of Health

Grant: 1DP2DK098092-01

Unlocking Regenerative Potential through in Vivo Genetic Reprogramming

National Institutes of Health

Grant: 5R01DK068471-17

Epigenetic determinants of beta cell development and function

National Institutes of Health

Grant: 5T32GM008666-17

Training Program in Basic and Clinical Genetics

National Institutes of Health

Grant: 5R01DK064391-04

Genetic Regulation of Adiposity and Associated CVD Risks

National Institutes of Health

Grant: 3U01DK105541-02S1

Functional Analysis of T2D Associated Non-coding SNPs

goldLicense: cc-by

publisherhttps://doi.org/10.7554/elife.59067

repositoryhttps://doaj.org/article/ae2ad6bb2f8440508324b4fcde2ff75c

repositoryhttps://escholarship.org/uc/item/8qh1h6jt

repositoryhttp://europepmc.org/pmc/articles/PMC7864636

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7864636

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

AnimalsZebrafishHumansDiabetes Mellitus, Type 2Intracellular Signaling Peptides and ProteinsZebrafish ProteinsTranscription FactorsEpigenome

Keywords

HumanPancreasGeneticsZebrafishGenomicsType 2 diabeteschromatindevelopmental biologyGwasHescPrevention (rcdc)Type 2 (mesh)Regenerative Medicine3105 Genetics (for-2020)Regenerative Medicine (rcdc)Epigenome31 Biological sciences (for-2020)2.1 Biological and endogenous factorsAnimals (mesh)Biology (General)32 Biomedical and Clinical Sciences (for-2020)Humans (mesh)DiabetesQRIntracellular Signaling Peptides and ProteinsTranscription Factors (mesh)Biological SciencesEpigenome (mesh)Stem Cell Research - Embryonic - Human (rcdc)MedicineType 2QH301-705.51.1 Normal biological development and functioningScienceIntracellular Signaling Peptides and Proteins (mesh)0601 Biochemistry and Cell Biology (for)61042 Health sciences (for-2020)Diabetes MellitusAnimalsHumansObesityStem Cell Research - Embryonic - HumanZebrafish Proteins (mesh)Metabolic and endocrine1.1 Normal biological development and functioning (hrcs-rac)Obesity (rcdc)Biomedical and Clinical SciencesGenetics (rcdc)PreventionHealth sciences2.1 Biological and endogenous factors (hrcs-rac)Zebrafish ProteinsStem Cell ResearchStem Cell Research (rcdc)Zebrafish (mesh)Metabolic and endocrine (hrcs-hc)Diabetes Mellitus, Type 2Cardiovascular and Metabolic DiseasesDiabetes (rcdc)Biochemistry and Cell BiologyTranscription Factors

Sustainable Development Goals

SDG 13: 13. Climate action