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Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

eLife(2021)10.7554/elife.70992Source: DataRank Database

Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells is a research paper published in eLife (2021). On theSindex it has a DataRank of 1.9. It has been cited 96 times, with 79 citing works in its 1-hop citation network.

N/A

1.9DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access96 citations · 79 citing works in its network

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Linked data & code

cellosaurus hpa

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE173206 GSM3040844 GSM3040845 GSM3040852 GSM3040853 GSM3040858 GSM3040859 GSM3040864 GSM3040865 GSM2498580 GSM2498581 GSM2498582 GSM2498583 GSM2498584 GSM2498585 GSM2498586 GSM2498587 GSM3455653 GSM3455654 GSM3455657 GSM3455658 GSM3455661 GSM3455662 GSM3455665 SM3455666 GSM4160534 GSM4160535 GSM4160536 GSM4160537 GSM4160538 GSM4160539 GSM4160540 GSM4160541 GSM4160542 GSM4160543 GSM3980129 GSM4008656 GSM4008657 GSM4008658 GSE76381 GSE119212

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 5.72)OA: goldTopics (36)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 35%Citation Network 65%

Base Score Contribution

0.686

From this paper's citation signal

Citation Network Contribution

1.3

From 59 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 79 citers.

Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes
Stem Cell Reports202429 citations29 referencesContributes 0.117
Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma
Neuro-Oncology202348 citations36 referencesContributes 0.108
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy
Fluids and Barriers of the CNS202141 citations46 referencesContributes 0.081
Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSS-Induced Depressive-Like Behaviors
Neuroscience Bulletin202329 citations55 referencesContributes 0.062
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels
Fluids and Barriers of the CNS202276 citations74 referencesContributes 0.059

Authors (7)

Hideaki Nishihara ORCID,Scott G Canfield,Koji L Foreman,Britta Engelhardt ORCID,Sean P. Palecek ORCID

Live enrichment

PubMed:34755601 PMC:PMC8664294 OpenAlex:https://openalex.org/W3214109191

National Institutes of Health

Grant: R01 NS103844

National Institutes of Health

Grant: R01 NS107461

National Institutes of Health

Grant: T32 GM008349

National Science Foundation

Grant: 1747503

Graduate Research Fellowship Program (GRFP)

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Grant: 310030_189080

Japan Society for the Promotion of Science

Grant: Overseas Research Fellowship

NCI NIH HHS

Grant: P30 CA014520

National Institutes of Health

Grant: 2T32GM008349-16

Biotechnology Training Program

National Institutes of Health

Grant: 5R01NS107461-04

Mechanisms of Shear Induction of Blood-Brain Barrier Phenotypes in Human iPSC-derived Brain Endothelial Progenitors

National Institutes of Health

Grant: 5R01NS103844-05

Investigating Pericyte Roles in Blood-Brain Barrier Formation

National Institutes of Health

Grant: 5P30CA014520-18

CANCER CENTER SUPPORT

Swiss National Science Foundation

Grant: 189080

Brain Barriers ID: Identifying and detailing the molecular mechanisms regulating integrity and immune function of the brain barriers

Bern Center for Precision Medicine

FWCI

5.72

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://elifesciences.org/articles/70992.bib

publisherhttps://elifesciences.org/articles/70992.bib

publisherhttps://cdn.elifesciences.org/articles/70992/elife-70992-v3.pdf

publisherhttps://cdn.elifesciences.org/articles/70992/elife-70992-v3.xml

publisherhttps://elifesciences.org/articles/70992

Fields of Study

Barrier Structure and Function StudiesNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

MeSH Terms

Blood-Brain BarrierCell LineHumansPluripotent Stem CellsEndothelial CellsWnt Signaling Pathway

Keywords

Wnt signaling pathwayInduced pluripotent stem cellTranscriptomeEndothelial stem cellSignal transductionStem cellIn vitroPhenotypeHumanNeurosciencedevelopmental biologyEndothelial CellsWnt signalingHuman Pluripotent Stem CellsBlood–brain BarrierBarriergenesisPluripotent Stem CellsQH301-705.5Science610Cell LineHumansBiology (General)QRBlood-Brain BarrierMedicine

Sustainable Development Goals

SDG 3: 3. Good health