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Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

eLife(2022)10.7554/elife.79348Source: DataRank Database

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation is a dataset published in eLife (2022). On theSindex it has a DataRank of 1.3, placing it in the top 15.3% of the data-sharing corpus. It has been cited 45 times, with 34 citing works in its 1-hop citation network.

Top 15%percentile

1.3DataRank

Ranks in the top 15% for downstream scientific impact

Data paper Open Access45 citations · 34 citing works in its network

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Linked data & code

refsnp doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 8.73)OA: goldTopics (48)Linked Datasets (17)DataCite Reuse (17)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (1/3)

Dataset classification

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DataRank Breakdown

Base Score 43%Citation Network 57%

Base Score Contribution

0.574

From this paper's citation signal

Citation Network Contribution

0.774

From 28 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 34 citers.

Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases
BMC Medicine202411 citations29 referencesContributes 0.086
Exploiting the mediating role of the metabolome to unravel transcript-to-phenotype associations
eLife202338 citations46 referencesContributes 0.080
Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank
The American Journal of Human Genetics202327 citations50 referencesContributes 0.067
Healthy Lifestyle, Metabolic Signature, and Risk of Cardiovascular Diseases: A Population-Based Study
Nutrients202411 citations46 referencesContributes 0.054
Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to the Development of Hypertension and Coronary Heart Disease
Hypertension202421 citations60 referencesContributes 0.052

Authors (7)

Nicholas A. Sinnott-Armstrong ORCID,Anna Cichońska ORCID,Heli Julkunen ORCID,Eric B. Fauman ORCID,Peter Würtz ORCID

Live enrichment

PubMed:36073519 PMC:PMC9536840 OpenAlex:https://openalex.org/W4294905117

Stanford Knight-Hennessy Scholars Program

Grant: Graduate Student Fellowship

National Institute of Health

Grant: 5R01HG011432 and 5R01AG066490

NHGRI NIH HHS

Grant: R01 HG011432

Medical Research Council

Grant: MC_PC_17228

Medical Research Council

Grant: MC_QA137853

NHGRI NIH HHS

Grant: R01 HG008140

NIA NIH HHS

Grant: R01 AG066490

National Institutes of Health

Grant: 1R01AG066490-01

Mapping Molecular and Phenotypic Interactions in Alzheimers Disease

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01HG011432-03

New methods for constructing and evaluating polygenic scores

FWCI

8.73

Citation Percentile

1.0%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.7554/elife.79348

publisherhttps://doi.org/10.7554/elife.79348

publisherhttps://cdn.elifesciences.org/articles/79348/elife-79348-v2.pdf

publisherhttps://cdn.elifesciences.org/articles/79348/elife-79348-v2.xml

publisherhttps://elifesciences.org/articles/79348

Fields of Study

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry StudiesBioinformatics and Genomic Networks0301 basic medicine0303 health sciences03 medical and health sciencesAmino AcidsGenetic PleiotropyGenome-Wide Association StudyKetonesPhenotypePolymorphism, Single Nucleotide

MeSH Terms

Amino AcidsKetonesPhenotypePolymorphism, Single NucleotideGenome-Wide Association StudyGenetic Pleiotropy

Keywords

PleiotropyGenome-wide association studyBiologyMetabolomicsComputational biologyContext (archaeology)MetabolomeGeneticsGenetic associationGenePhenotypeBioinformaticsSingle-nucleotide polymorphismGenotypeHumanMetabolitesGenomicsGwasGenetic ArchitectureQH301-705.5ScienceQRGenetics and GenomicsGenetic PleiotropyKetonesPolymorphism, Single NucleotideMedicineBiology (General)Amino Acids

Additional file 1 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641372.v1figshare

Additional file 1 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641372figshare

Additional file 2 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641375.v1figshare

Additional file 2 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641375figshare

Pleiotropy of UK Biobank metabolites

10.5061/dryad.79cnp5hxsDryad

Additional file 7 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641393.v1figshare

Additional file 6 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641390.v1figshare

Additional file 6 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641390figshare

Additional file 7 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641393figshare

Additional file 4 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641384figshare

Additional file 5 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641387figshare

Additional file 3 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641378figshare

Additional file 4 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641384.v1figshare

Additional file 5 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641387.v1figshare

Additional file 3 of Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke

10.6084/m9.figshare.26641378.v1figshare

Pleiotropy of UK Biobank metabolites

10.5281/zenodo.6480199Zenodo

Pleiotropy of UK Biobank metabolites

10.5281/zenodo.6480200Zenodo

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Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (7)

Funding (10 grants)

Impact

Open Access

Topics

Linked Datasets (17)

Annotations (Europe PMC)

Related Papers (10)