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Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells

eLife(2024)10.7554/elife.82809Source: DataRank Database

Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells is a research paper published in eLife (2024). On theSindex it has a DataRank of 0.597. It has been cited 19 times, with 18 citing works in its 1-hop citation network.

N/A

0.597DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access19 citations · 18 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

Dryad10.5061/dryad.6wwpzgn5v

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)OA: goldTopics (29)IDs (PubMed, PMC)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 75%Citation Network 25%

Base Score Contribution

0.449

From this paper's citation signal

Citation Network Contribution

0.148

From 10 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 18 citers.

Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits
Cell202593 citations108 referencesContributes 0.042
The power of human stem cell-based systems in the study of neurodevelopmental disorders
Current Opinion in Neurobiology20248 citations64 referencesContributes 0.034
The epilepsy–autism phenotype associated with developmental and epileptic encephalopathies: New mechanism‐based therapeutic options
Epilepsia202524 citations147 referencesContributes 0.022
p70 ribosomal protein S6 Kinase (p70S6K) as a potential peripheral biomarker for mental symptoms in 16p11.2 deletion and duplication syndromes
bioRxiv (Cold Spring Harbor Laboratory)20261 citations33 referencesContributes 0.021
Dysregulation of the mTOR-FMRP pathway and synaptic plasticity in an environmental model of ASD
Molecular Psychiatry202411 citations132 referencesContributes 0.019

Authors (12)

Bharati Dev,Cynthia Peng,Monal Mehta,Rohan Alibutud,Robert Connacher ORCID

Live enrichment

PubMed:38525876 PMC:PMC11003747

New Jersey Governor's Council for Medical Research and Treatment of Autism

Grant: CAUT13APS010

New Jersey Governor's Council for Medical Research and Treatment of Autism

Grant: CAUT14APL031

New Jersey Governor's Council for Medical Research and Treatment of Autism

Grant: CAUT15APL041

New Jersey Governor's Council for Medical Research and Treatment of Autism

Grant: CAUT19APL014

New Jersey Health Foundation

Grant: PC 63-19

Autism Science Foundation

Grant: Summer Undergraduate Research Grant

Rutgers School of Graduate Studies

Grant: Thesis Finishing Grant

New Jersey Governor's Council for Medical Research and Treatment of Autism

Grant: CAUT19APL028

National Institutes of Health

Grant: R25 5R25MH119043-05

NIMH NIH HHS

Grant: R25 MH119043

National Institutes of Health

Grant: 5R25MH119043-05

Educating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientists

Mindworks Charitable Lead Trust

Nancy Lurie Marks Family Foundation

Jewish Community Foundation of Greater MetroWest NJ

goldLicense: CC BY

publisherhttps://cdn.elifesciences.org/articles/82809/elife-82809-v2.pdf

publisherhttps://cdn.elifesciences.org/articles/82809/elife-82809-v2.xml

publisherhttps://elifesciences.org/articles/82809

Europe_PMChttps://europepmc.org/articles/PMC11003747

Europe_PMChttps://europepmc.org/articles/PMC11003747?pdf=render

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

NeuritesHumansAutistic DisorderTOR Serine-Threonine KinasesNeural Stem CellsAutism Spectrum Disorder

Keywords

HumanNeurodevelopmentNeurosciencedevelopmental biologycell migrationAutismMtorNeuritesIpscQH301-705.5Autism Spectrum DisorderScienceTOR Serine-Threonine KinasesQRNeural Stem CellsMedicineHumansBiology (General)Autistic Disorder

Sustainable Development Goals

SDG 3: 3. Good healthSDG 10: 10. No inequality