Colleen M. Niswender

Also affiliated with Vanderbilt University, Institute of Chemical Biology and Fundamental Medicine, Kennedy Center, Health Advances (United States), Center for Discovery, Vanderbilt Health, Vanderbilt University Medical Center

NeuroscienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 37 papers. Top paper: “Trofinetide: a pioneering treatment for Rett syndrome”.

Trofinetide: a pioneering treatment for Rett syndrome

Trends in Pharmacological Sciences(2023)10.1016/j.tips.2023.06.008

N/A

0.785DataRank · unranked

24 citations

Anthony S. Ferranti, Colleen M. Niswender, Harrison H. Parent

mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits

Cell Reports(2021)10.1016/j.celrep.2021.109950

N/A

0.561DataRank · unranked

41 citations

Nellie Byun, Deborah J. Luessen, Brianna Li, Robert Barry, John C. Gore +5 more

A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes

JCI Insight(2021)10.1172/jci.insight.143324

N/A

0.520DataRank · unranked

31 citations

Aqeela AlHashim, Aditi Buch, Hana Badivuku, Manar Samman, Kelly Weiss +8 more

Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.4c00769

N/A

0.457DataRank · unranked

11 citations

Michael R. Wood, Changho Han, Shaun R. Stauffer, Joseph D. Panarese, Bruce J. Melancon +21 more

Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer

Nature Communications(2024)10.1038/s41467-024-52822-4

N/A

0.406DataRank · unranked

14 citations

Davide Provasi, Colleen M. Niswender, Wesley B. Asher, Jonathan A. Javitch, Xin Lin

MeCP2 gene therapy ameliorates disease phenotype in mouse model for Pitt Hopkins syndrome

Neurotherapeutics(2024)10.1016/j.neurot.2024.e00376

N/A

0.312DataRank · unranked

7 citations

Sheryl Anne D. Vermudez, Robert J.M. Deacon, Julieth A. Sierra-Delgado, Kelly Rich, Xiaojin Zhang +12 more

Exploration of group II metabotropic glutamate receptor modulation in mouse models of Rett syndrome and MECP2 Duplication syndrome

Neuropharmacology(2022)10.1016/j.neuropharm.2022.109022

N/A

0.292DataRank · unranked

6 citations

Aditi Buch, Kelly Weiss, Rocco G. Gogliotti, Colleen M. Niswender, Sheryl Anne D. Vermudez

Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128923

N/A

0.208DataRank · unranked

3 citations

Alice L. Rodriguez, Jacob J. Kalbfleisch, Mabel Seto, Matthew T. Jenkins, Anna L. Blobaum +4 more

Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102458

N/A

0DataRank · unranked

23 citations

Nicole M. Fisher, Shalini Dogra, Rebecca K. Senter, Carson W. Reed, Jacob J. Kalbfleisch +6 more

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

Neurotherapeutics(2022)10.1007/s13311-022-01254-3

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0DataRank · unranked

14 citations

Bright Arthur, Jakub Cikowski, Calista Holt, Sonia Gonzalez, Nicole M. Fisher +5 more

GRM7 gene mutations and consequences for neurodevelopment

Pharmacology Biochemistry and Behavior(2023)10.1016/j.pbb.2023.173546

N/A

0DataRank · unranked

18 citations

Colleen M. Niswender, Geanne A. Freitas

Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits

Biological Psychiatry(2023)10.1016/j.biopsych.2023.11.023

N/A

0DataRank · unranked

3 citations

Caleb Aguayo, Zixiu Xiang, Jason Putnam, J. R. Smith, Curran Johnston +5 more

Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor

Molecular Pharmacology(2023)10.1124/molpharm.122.000643

N/A

0DataRank · unranked

6 citations

Haley E. Kling, Natasha B. Billard, Alice L. Rodriguez, Peng Li, Jonathan W. Dickerson +7 more

Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7

Molecular Pharmacology(2023)10.1124/molpharm.123.000678

N/A

0DataRank · unranked

3 citations

Christopher S. Hofmann, Alice L. Rodriguez, Colleen M. Niswender, Xia Lei

Profiling Context-Dependent Activity of Allosteric Modulators at mGlu7

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.153810

N/A

0DataRank · unranked

0 citations

Alice L. Rodriguez, Colleen M. Niswender, Xia Lei

Novel pharmacological targets for GABAergic dysfunction in ADHD

Neuropharmacology(2024)10.1016/j.neuropharm.2024.109897

N/A

0DataRank · unranked

40 citations

Deborah J. Luessen, Colleen M. Niswender, Anthony S. Ferranti

The cannabinoid CB 2 receptor positive allosteric modulator EC21a exhibits complicated pharmacology in vitro

Journal of Receptors and Signal Transduction(2024)10.1080/10799893.2024.2431986

N/A

0DataRank · unranked

7 citations

Xueqing Han, Marc Quitalig, Jessica Wu, Plamen P. Christov, KyuOk Jeon +7 more

Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.4c00508

N/A

0DataRank · unranked

8 citations

Katrina A. Bollinger, Rory A. Capstick, Madeline F. Long, Aaron M. Bender, Jonathan W. Dickerson +14 more

Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile

ACS Medicinal Chemistry Letters(2024)10.1021/acsmedchemlett.4c00249

N/A

0DataRank · unranked

6 citations

Sean R. Bollinger, Julie L. Engers, Madeline F. Long, Sichen Chang, Vincent B. Luscombe +9 more

Discovery of VU6024578/BI02982816: An mGlu1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c02554

N/A

0DataRank · unranked

3 citations

Jacob F. Kalbfleisch, Jeremy A. Turkett, Trevor A. Trombley, Anthony F. Nastase, Paul K. Spearing +17 more

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

Molecular Pharmacology(2024)10.1124/molpharm.124.000874

N/A

0DataRank · unranked

5 citations

Colleen M. Niswender, Harrison H. Parent

Potentiation of the muscarinic acetylcholine receptor 1 modulates neurophysiological features in a mouse model of Rett syndrome

Neurotherapeutics(2024)10.1016/j.neurot.2024.e00384

N/A

0DataRank · unranked

4 citations

Kelly Weiss, Kathryn Baugh, Mac Meadows, Colleen M. Niswender, Jeffrey L. Neul +1 more

Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

ACS Medicinal Chemistry Letters(2025)10.1021/acsmedchemlett.5c00119

N/A

0DataRank · unranked

2 citations

Scott H. Henderson, Rory A. Capstick, David Whomble, Aaron M. Bender, Andrew S. Felts +18 more

Profiling the Impact of mGlu7/Elfn1 Protein Interactions on the Pharmacology of mGlu7 Allosteric Modulators

ACS Chemical Neuroscience(2025)10.1021/acschemneuro.5c00174

N/A

0DataRank · unranked

2 citations

Zixiu Xiang, Alice L. Rodriguez, M Wilson, Colleen M. Niswender, Xia Lei

Characterization of Novel and Known Activators of Cannabinoid Receptor Subtype 2 Reveals Mixed Pharmacology That Differentiates Mycophenolate Mofetil and GW-842,166X from MDA7

International Journal of Molecular Sciences(2025)10.3390/ijms26104956

N/A

0DataRank · unranked

1 citations

Aidong Qi, Allie Han, Haley E. Kling, Marc Quitalig, Aaron M. Bender +5 more

Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.08.652716

N/A

0DataRank · unranked

1 citations

Geanne A. Freitas, MacKenzie Smith, Rocco D. Gogliotti, Colleen M. Niswender, Sheryl Anne D. Vermudez

Further Optimization of the mGlu1 PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685

ACS Chemical Neuroscience(2025)10.1021/acschemneuro.5c00014

N/A

0DataRank · unranked

0 citations

Jacob F. Kalbfleisch, Jeremy A. Turkett, Trevor A. Trombley, Paul K. Spearing, Daniel H. Haymer +16 more

Characterization of Novel and Known Activators of Cannabinoid Receptor Subtype 2 Reveals Mixed Pharmacology that Differentiates Mycophenolate Mofetil and GW-842,166X from MDA7

Preprints.org(2025)10.20944/preprints202504.1842.v1

N/A

0DataRank · unranked

0 citations

Aidong Qi, Allie Han, Haley E. Kling, Marc Quitalig, Aaron M. Bender +5 more

Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity

Bioorganic & Medicinal Chemistry Letters(2020)10.1016/j.bmcl.2020.127212

N/A

0DataRank · unranked

7 citations

Matthew T. Loch, Alice L. Rodriguez, Xin Lin, Jonathan A. Javitch, P. Jeffrey Conn +3 more

Strategies and requirements for the detection of RNA editing in G protein coupled-receptor RNA

Methods in Enzymology(2002)10.1016/s0076-6879(02)43153-9

N/A

0DataRank · unranked

0 citations

Colleen M. Niswender

Discovery of the first selective M 4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.12.324152

N/A

0DataRank · unranked

1 citations

Aaron M. Bender, Jonathan W. Dickerson, Daniel J. Foster, Yuping Donsante, Weimin Peng +14 more

Activating mGlu 3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.27.356196

N/A

0DataRank · unranked

1 citations

Branden J. Stansley, Zixiu Xiang, Weilun Qian, Rocco G. Gogliotti, Ferdinando Nicoletti +5 more

Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Biological Psychiatry(2021)10.1016/j.biopsych.2021.02.970

N/A

0DataRank · unranked

47 citations

Branden J. Stansley, Zixiu Xiang, Weilun Qian, Rocco G. Gogliotti, Ferdinando Nicoletti +5 more

Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model

Genes Brain & Behavior(2021)10.1111/gbb.12752

N/A

0DataRank · unranked

14 citations

Rocco G. Gogliotti, Bright Arthur, Aditi Buch, Clarissa Morales, Yuta Moxley +4 more

Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128416

N/A

0DataRank · unranked

8 citations

Rory A. Capstick, Paul K. Spearing, Julie L. Engers, Alison R. Gregro, Sean R. Bollinger +11 more

Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors

Neuropsychopharmacology(2021)10.1038/s41386-021-01041-2

N/A

0DataRank · unranked

12 citations

Chiaki I. Santiago, Sheryl Anne D. Vermudez, Nicole M. Fisher, Shalini Dogra, Colleen M. Niswender +2 more

Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00192

N/A

0DataRank · unranked

23 citations

Douglas L. Orsi, Rory A. Capstick, David Whomble, Jinming Li, Trever R. Carter +21 more