Thomas E. Wales

Also affiliated with Universidad del Noreste

ChemistryBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 34 papers. Top paper: “The heme-regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation”.

The heme-regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.012803

N/A

0.722DataRank · unranked

25 citations

Amanda L. Gunawan, Brent Kochert, Liu Liu, Thomas E. Wales, Maelyn C. Borowy +3 more

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

Molecular Cell(2021)10.1016/j.molcel.2021.11.033

N/A

0.663DataRank · unranked

82 citations

Hao Li, Daniele Peterle, Joao A. Paulo, Scott B. Ficarro, Thomas E. Wales +5 more

Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α

Molecular Cell(2023)10.1016/j.molcel.2023.05.008

N/A

0.628DataRank · unranked

65 citations

Thomas E. Wales, Haixia Zhou, Sorin-Valeriu Draga-Coletă, Christoph Gorgulla, Katherine Blackmore +17 more

Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization

Molecular Cell(2020)10.1016/j.molcel.2020.05.029

N/A

0.598DataRank · unranked

53 citations

Edward P. Harvey, Catherine E. Newman, Thomas E. Wales, Joel C. Bucci, Julian Mintseris +14 more

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core

Nature Communications(2021)10.1038/s41467-021-25200-7

N/A

0.561DataRank · unranked

41 citations

Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen, Loren D. Walensky +1 more

Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering

Cell chemical biology(2020)10.1016/j.chembiol.2020.04.004

N/A

0.546DataRank · unranked

37 citations

Zachary J. Hauseman, Daniel T. Cohen, T.J. Rettenmaier, Susan Lee, Annissa J. Huhn +11 more

Identification of a Structural Determinant for Selective Targeting of HDMX

Structure(2020)10.1016/j.str.2020.04.011

N/A

0.345DataRank · unranked

9 citations

Hyuk‐Soo Seo, Edward P. Harvey, Zachary J. Hauseman, Thomas E. Wales, Catherine E. Newman +5 more

Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis

Journal of Molecular Biology(2024)10.1016/j.jmb.2024.168837

N/A

0.330DataRank · unranked

8 citations

Tatiana Prokaeva, Brian Spencer, Sherry Wong, Shreya Ghosh, Angela Urdaneta +4 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488

N/A

0.330DataRank · unranked

8 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.21.465358

N/A

0.312DataRank · unranked

7 citations

Hao Li, Daniele Peterle, Joao A. Paulo, Scott B. Ficarro, Thomas E. Wales +5 more

Inhibition of oligomeric BAX by an anti-apoptotic dimer

Cell(2025)10.1016/j.cell.2025.10.037

N/A

0.292DataRank · unranked

6 citations

Micah A. Gygi, Haleh Alimohamadi, Thomas M. DeAngelo, Christina M. Camara, Julian Mintseris +16 more

Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices

Nature Communications(2025)10.1038/s41467-025-63657-y

N/A

0.292DataRank · unranked

6 citations

Utsarga Adhikary, Kyle J. Korshavn, Hyuk‐Soo Seo, Clara R. Brotzen-Smith, Christina M. Camara +5 more

Resolving chaperone-assisted protein folding on the ribosome at the peptide level

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.23.509153

N/A

0.269DataRank · unranked

5 citations

Aleksandra Pajak, Alžběta Roeselová, Santosh Shivakumaraswamy, Steven Howell, F. Ulrich Hartl +3 more

An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.108088

N/A

0.165DataRank · unranked

2 citations

Gabriella Gerlach, Giancarlo Gonzalez-Areizaga, Thomas E. Wales, Stephanie Y. Cui, Prema Iyer +5 more

A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.167310

N/A

0DataRank · unranked

23 citations

Elena S. Klimtchuk, Thomas E. Wales, Florian Georgescauld, Lawreen H. Connors, John R. Engen +2 more

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

eLife(2023)10.7554/elife.89489

N/A

0DataRank · unranked

13 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2

N/A

0DataRank · unranked

4 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.18.572223

N/A

0DataRank · unranked

2 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.02.543453

N/A

0DataRank · unranked

1 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Reviewer #2 (Public Review): Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2.sa1

N/A

0DataRank · unranked

0 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Reviewer #1 (Public Review): Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2.sa2

N/A

0DataRank · unranked

0 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Author Response: Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2.sa4

N/A

0DataRank · unranked

0 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Covalent inhibition of pro-apoptotic BAX

Nature Chemical Biology(2024)10.1038/s41589-023-01537-6

N/A

0DataRank · unranked

23 citations

Peiwen Shi, Christina M. Camara, Daniel T. Cohen, T.J. Rettenmaier, Utsarga Adhikary +8 more

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX

Cell Reports(2020)10.1016/j.celrep.2020.02.057

N/A

0DataRank · unranked

32 citations

Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky, Daniel T. Cohen

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

eLife(2024)10.7554/elife.89489.3

N/A

0DataRank · unranked

1 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer

Nature Chemical Biology(2020)10.1038/s41589-020-0625-7

N/A

0DataRank · unranked

8 citations

Gregory H. Bird, Thomas E. Wales, Henry D. Herce, Edward P. Harvey, Zachary J. Hauseman +8 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488.1

N/A

0DataRank · unranked

1 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488.2

N/A

0DataRank · unranked

0 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Rigorous Analysis of Multimodal HDX-MS Spectra

Journal of the American Society for Mass Spectrometry(2025)10.1021/jasms.4c00471

N/A

0DataRank · unranked

22 citations

Ellie I. James, Florian Georgescauld, Thomas E. Wales, David D. Weis, John R. Engen +4 more

Allosteric activation mechanism of DriD, a WYL-domain containing transcription regulator

Communications Biology(2025)10.1038/s42003-025-08111-x

N/A

0DataRank · unranked

8 citations

Bindu Y. Srinivasu, Jose Chavez Orozco, Kevin Gozzi, Thomas E. Wales, Maria A. Schumacher +1 more

Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.01.029

N/A

0DataRank · unranked

22 citations

Meera Kumanan, Thomas E. Wales, Asanga Bandara, Marcus Fändrich, John E. Straub +3 more

ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr

Structure(2022)10.1016/j.str.2022.08.008

N/A

0DataRank · unranked

16 citations

John J. Alvarado, Thomas E. Wales, Jamie A. Moroco, John R. Engen, Thomas E. Smithgall +1 more

The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.167422

N/A

0DataRank · unranked

9 citations

Jacques Lowe, D. Bruce Fulton, John R. Engen, Thomas E. Wales, Amy H. Andreotti +1 more

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency

Nature Communications(2022)10.1038/s41467-022-31466-2

N/A

0DataRank · unranked

13 citations

Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy +10 more