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Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488.2Source: DataRank Database

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia is a research paper published in eLife (2024). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (1 grants)OA: goldTopics (45)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (8)

Thomas E. Wales ORCID,Sandrine Jayne ORCID,Robert G. Britton ORCID,D. Bruce Fulton,John R. Engen ORCID

Live enrichment

PubMed:26657633 OpenAlex:https://openalex.org/W4404372816

National Institutes of Health

Grant: 5R01AI043957-05

STRUCTURAL STUDIES OF A T CELL SPECIFIC TYROSINE KINASE

goldLicense: cc-by

journalhttps://elifesciences.org/reviewed-preprints/95488v2.pdf

publisherhttps://elifesciences.org/reviewed-preprints/95488v2.pdf

publisherhttps://cdn.elifesciences.org/preprints/95488/elife-preprint-95488-v2.pdf

publisherhttps://cdn.elifesciences.org/preprints/95488/elife-preprint-95488-v2.xml

publisherhttps://elifesciences.org/reviewed-preprints/95488v2/pdf

Fields of Study

Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and TreatmentChronic Myeloid Leukemia Treatments0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

Bruton's tyrosine kinaseChronic lymphocytic leukemiaIbrutinibMedicineMutationCancer researchImmunologyGeneticsLeukemiaInternal medicineBiologyGeneTyrosine kinaseReceptorkinase inhibitorQH301-705.5Protein ConformationSciencePiperidinesBruton’s tyrosine kinaseBiochemistry and Chemical BiologyAgammaglobulinaemia Tyrosine KinaseHumansBiology (General)Protein Kinase InhibitorsallosteryAdenineQRImidazolesLeukemia, Lymphocytic, Chronic, B-CellPyrimidinesBTKDrug Resistance, Neoplasmresistance mutationsPyrazinesBenzamidesPyrazolesCLL

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being