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Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488Source: DataRank Database

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia is a research paper published in eLife (2024). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)OA: goldTopics (59)IDs (PubMed, OpenAlex)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Thomas E. Wales ORCID,Sandrine Jayne ORCID,Robert G. Britton ORCID,D. Bruce Fulton,John R. Engen ORCID

Live enrichment

PubMed:39728925 OpenAlex:https://openalex.org/W4393111884

National Institute of Allergy and Infectious Diseases

Grant: AI43957

Experimental Cancer Medicine Centre

Grant: C10604/A25151

National Institutes of Health

Grant: 5R01AI043957-05

STRUCTURAL STUDIES OF A T CELL SPECIFIC TYROSINE KINASE

goldLicense: cc-by

journalhttps://elifesciences.org/reviewed-preprints/95488.pdf

publisherhttps://elifesciences.org/reviewed-preprints/95488.pdf

publisherhttps://cdn.elifesciences.org/articles/95488/elife-95488-v1.pdf

publisherhttps://cdn.elifesciences.org/articles/95488/elife-95488-v1.xml

publisherhttps://elifesciences.org/articles/95488

Fields of Study

Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and TreatmentChronic Myeloid Leukemia Treatments0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Agammaglobulinaemia Tyrosine KinaseAdenineBenzamidesHumansImidazolesMutationPiperidinesProtein ConformationPyrazinesPyrazolesPyrimidinesLeukemia, Lymphocytic, Chronic, B-CellDrug Resistance, NeoplasmProtein Kinase Inhibitors

Keywords

Bruton's tyrosine kinaseChronic lymphocytic leukemiaIbrutinibCancer researchMedicineImmunologyMutationLeukemiaBiologyGeneticsTyrosine kinaseInternal medicineGeneReceptorkinase inhibitorQH301-705.5Protein ConformationSciencePiperidinesBruton’s tyrosine kinaseBiochemistry and Chemical BiologyAgammaglobulinaemia Tyrosine KinaseHumansBiology (General)Protein Kinase InhibitorsallosteryAdenineQRImidazolesLeukemia, Lymphocytic, Chronic, B-CellPyrimidinesBTKDrug Resistance, Neoplasmresistance mutationsPyrazinesBenzamidesPyrazolesCLL

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being