Karen L. Mohlke

University of North Carolina at Chapel Hill

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

2.7Author DataRank

Indexed papers

12in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 12 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits

Genome Research(2021)10.1101/gr.268482.120

Top 11%

1.9DataRank

Top 11%61 citations

Nandini Manickam, Christa Ventresca, Swarooparani Vadlamudi, Arushi Varshney, Vivek Rai +7 more

Papers

Driven by 130 papers — median percentile 19. Top paper: “Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19 -associated CTCF-binding sites in colorectal cancer”.

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19 -associated CTCF-binding sites in colorectal cancer

Proceedings of the National Academy of Sciences(2000)10.1073/pnas.98.2.591

N/A

12.0DataRank · unranked

229 citations

George Eliot Hospital NHS Trust, Nuneaton, UK, Päivi Peltomäki, Randi Istrup Pedersen, Karen L. Mohlke, Albert de la Chapelle +2 more

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Cell(2020)10.1016/j.cell.2020.06.045

N/A

8.3DataRank · unranked

739 citations

Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Arden Moscati +95 more

Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database

Genetic Epidemiology(2006)10.1002/gepi.20131

N/A

4.5DataRank · unranked

64 citations

Laura J. Scott, Lori L. Bonnycastle, Anne U. Jackson, Peter Chines, Randall Pruim +12 more

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Nature Communications(2022)10.1038/s41467-022-29143-5

N/A

3.9DataRank · unranked

196 citations

Lap Sum Chan, Debraj Bose, Anne Jackson, Peter VandeHaar, Adam E. Locke +33 more

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Nature Communications(2021)10.1038/s41467-021-23556-4

N/A

2.7DataRank · unranked

110 citations

Moriel Singer‐Berk, Rachel G. Son, Abigail Sveden, Jordan C. Wood, Eleina England +95 more

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

Nature Communications(2020)10.1038/s41467-020-18581-8

N/A

2.4DataRank · unranked

164 citations

Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda J. Bennett +31 more

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

PLoS Genetics(2020)10.1371/journal.pgen.1009018

N/A

2.0DataRank · unranked

71 citations

Marcus Alvarez, Arthur Ko, Yash Bhagat, Elior Rahmani, Brandon Jew +11 more

Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits

Genome Research(2021)10.1101/gr.268482.120

Top 11%

1.9DataRank

Top 11%61 citations

Nandini Manickam, Christa Ventresca, Swarooparani Vadlamudi, Arushi Varshney, Vivek Rai +7 more

Genetic effects on liver chromatin accessibility identify disease regulatory variants

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.05.001

N/A

1.6DataRank · unranked

70 citations

Michael R. Erdos, Narisu Narisu, Vivek Rai, Swarooparani Vadlamudi, Hannah J. Perrin +41 more

Model-based assessment of replicability for genome-wide association meta-analysis

Nature Communications(2021)10.1038/s41467-021-21226-z

N/A

1.5DataRank · unranked

40 citations

Yu Jiang, Mengzhen Liu, J. Dylan Weissenkampen, Scott A. Eckert, Lina Yang +125 more

Identification of genetic effects underlying type 2 diabetes in South Asian and European populations

Communications Biology(2022)10.1038/s42003-022-03248-5

N/A

1.5DataRank · unranked

62 citations

Weihua Zhang, Hong Kiat Ng, Katharina T. Schmid, Amel Lamri, Tong Lin +42 more

ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19

International Journal of Obesity(2022)10.1038/s41366-022-01136-w

N/A

1.3DataRank · unranked

44 citations

Anne Jackson, Sarah M. Brotman, Li Guan, Sergio Villicaña, Amy L. Roberts +31 more

Partitioning heritability by functional annotation using genome-wide association summary statistics

Nature Genetics(2015)10.1038/ng.3404

N/A

1.2DataRank · unranked

3020 citations

Hilary K. Finucane, Anders D. Børglum, The RACI Consortium, Brendan K Bulik-Sullivan, Alexander Gusev +22 more

Clinical use of current polygenic risk scores may exacerbate health disparities

Nature Genetics(2019)10.1038/s41588-019-0379-x

N/A

1.2DataRank · unranked

2850 citations

Masahiro Kanai, Yoichiro Kamatani, Karen L. Mohlke, Michael C O'Donovan, Coleen Damcott +1 more

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

Proceedings of the National Academy of Sciences(2017)10.1073/pnas.1705859115

N/A

1.2DataRank · unranked

36 citations

Alisa Manning, Marcio Almeida, Matthew Zawistowski, Katharina Domschke, Tanya M. Teslovich +82 more

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Nature Genetics(2019)10.1038/s41588-018-0307-5

N/A

1.1DataRank · unranked

2128 citations

Mengzhen Liu, HUNT All-In Psychiatry, Yu Jiang, Robbee Wedow, Yue Li +120 more

Defining the role of common variation in the genomic and biological architecture of adult human height

Nature Genetics(2014)10.1038/ng.3097

N/A

1.1DataRank · unranked

2093 citations

Emilio Rodríguez-Ruiz, The PAGE Consortium, Diana O. Perkins, Tonu Esko, Jian Yang +479 more

Deciphering the impact of genomic variation on function

Nature(2024)10.1038/s41586-024-07510-0

N/A

1.1DataRank · unranked

89 citations

Jesse M. Engreitz, Heather A. Lawson, Harinder Singh, Lea M. Starita, Gary C. Hon +95 more

The genetic architecture of type 2 diabetes

Nature(2016)10.1038/nature18642

N/A

1.1DataRank · unranked

1106 citations

Menachem Fromer, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton +334 more

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Nature Genetics(2018)10.1038/s41588-018-0047-6

N/A

1.0DataRank · unranked

901 citations

Masato Akiyama, Atsushi Takahashi, Nana Matoba, Yukihide Momozawa, Masashi Ikeda +8 more

Seven new loci associated with age-related macular degeneration

Nature Genetics(2013)10.1038/ng.2578

N/A

1.0DataRank · unranked

798 citations

Lars G. Fritsche, Wei Chen, Brian L. Yaspan, Yi Yu, Guðmar Þorleifsson +141 more

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Cell(2020)10.1016/j.cell.2020.08.008

N/A

0.988DataRank · unranked

722 citations

Erik L. Bao, Parsa Akbari, Caleb A. Lareau, Abdou Mousas, Tao Jiang +95 more

Loci for insulin processing and secretion provide insight into type 2 diabetes risk

The American Journal of Human Genetics(2023)10.1016/j.ajhg.2023.01.002

N/A

0.984DataRank · unranked

46 citations

Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P Wilson, Anne H. Moxley +66 more

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Science(2014)10.1126/science.1249547

N/A

0.948DataRank · unranked

556 citations

Sara Mostafavi, Chun Jimmie Ye, Mark N. Lee, Joseph M. Replogle, Ting Feng +22 more

Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research

Genetics(2020)10.1534/genetics.120.303596

N/A

0.710DataRank · unranked

113 citations

Matthew W Blanchard, Ralph S. Baric, Timothy A. Bell, Jennifer Brennan, Gudrun A. Brockmann +64 more

High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools

Proceedings of the National Academy of Sciences(2002)10.1073/pnas.262661399

N/A

0.702DataRank · unranked

107 citations

Michael R. Erdos, Laura J. Scott, Tasha E. Fingerlin, Anne U. Jackson, Kaisa Silander +4 more

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

European Journal of Epidemiology(2020)10.1007/s10654-020-00638-z

N/A

0.670DataRank · unranked

12 citations

Tao Huang, Tiange Wang, Zhendong Mei, Zhonghan Sun, Tao Zhang +95 more

Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

Genome biology(2024)10.1186/s13059-023-03136-z

N/A

0.629DataRank · unranked

16 citations

Rachel L. Kember, Anna Ulrich, Zhanna Balkhiyarova, Akram Alyass, Izzuddin M. Aris +95 more

Current clinical use of polygenic scores will risk exacerbating health disparities

bioRxiv (Cold Spring Harbor Laboratory)(2018)10.1101/441261

N/A

0.568DataRank · unranked

43 citations

Masahiro Kanai, Yoichiro Kamatani, Karen L. Mohlke, Michael C O'Donovan, Coleen Damcott +1 more

Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2021.11.019

N/A

0.489DataRank · unranked

25 citations

Chelsea K. Raulerson, Swarooparani Vadlamudi, Kevin W. Currin, Qiujin Shen, Victoria A. Parsons +10 more

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits

Nature Genetics(2025)10.1038/s41588-024-01982-6

N/A

0.477DataRank · unranked

23 citations

Julia S. El-Sayed Moustafa, Li Guan, K. Alaine Broadaway, Dongmeng Wang, Anne Jackson +29 more

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

PLoS Genetics(2020)10.1371/journal.pgen.1009019

N/A

0.470DataRank · unranked

22 citations

Apoorva K. Iyengar, Swarooparani Vadlamudi, Chelsea K. Raulerson, Anne Jackson, Sarah M. Brotman +20 more

Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.26.563798

N/A

0.440DataRank · unranked

13 citations

Julia S. El-Sayed Moustafa, Li Guan, K. Alaine Broadaway, Dongmeng Wang, Anne Jackson +29 more

Opportunities and challenges of local ancestry in genetic association analyses

The American Journal of Human Genetics(2025)10.1016/j.ajhg.2025.03.004

N/A

0.425DataRank · unranked

16 citations

Andrea R.V.R. Horimoto, Brian Chen, Frank Ockerman, Karen L. Mohlke, Elizabeth Blue +3 more

Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits

Diabetes(2023)10.2337/db23-0365

N/A

0.425DataRank · unranked

16 citations

Anniina Oravilahti, Jonathan D. Rosen, Marcus Alvarez, Sini Heinonen, Birgitta W. van der Kolk +17 more

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors

Nature Neuroscience(2024)10.1038/s41593-024-01773-6

N/A

0.425DataRank · unranked

16 citations

Brandon D. Le, Jordan M. Valone, Justin M. Wolter, Jessica Mory, Dan Liang +8 more

Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults

Circulation Genomic and Precision Medicine(2021)10.1161/circgen.121.003421

N/A

0.416DataRank · unranked

15 citations

Laura M. Raffield, Anne H. Moxley, Tyne W. Miller‐Fleming, Paul L. Auer, Franceschini, Nora +12 more

Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

UNC Libraries(2020)10.17615/0pps-1042

N/A

0.400DataRank · unranked

6 citations

Ghenadie Curocichin, Leslie A. Lange, Linda S. Adair, Thomas W. McDade, Damien C. Croteau‐Chonka +7 more

Extensive differential gene expression and regulation by sex in human skeletal muscle

Cell Genomics(2025)10.1016/j.xgen.2025.100915

N/A

0.396DataRank · unranked

13 citations

Abigail S. Mauger, Arushi Varshney, Dan L. Ciotlos, Nandini Manickam, Narisu Narisu +20 more

Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci

Human Genetics and Genomics Advances(2024)10.1016/j.xhgg.2024.100275

N/A

0.396DataRank · unranked

13 citations

Swarooparani Vadlamudi, Kevin W. Currin, Anne H. Moxley, Jayna C. Nicholas, Jessica C. McAfee +3 more

Wnt activity reveals context-specific genetic effects on gene regulation in neural progenitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.07.527357

N/A

0.388DataRank · unranked

7 citations

Brandon D. Le, Jordan M. Valone, Justin M. Wolter, Jessica Mory, Dan Liang +8 more

Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing

The CRISPR Journal(2024)10.1089/crispr.2023.0066

N/A

0.385DataRank · unranked

12 citations

Amy J. Swift, Erin C. Mansell, Angela Lee, Elizabeth Winnicki, Elizabeth S. Li +9 more

ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

medRxiv(2020)10.1101/2020.08.11.20171108

N/A

0.385DataRank · unranked

12 citations

Anne Jackson, Sarah M. Brotman, Li Guan, Sergio Villicaña, Amy L. Roberts +21 more

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations

Nature Communications(2025)10.1038/s41467-025-63546-4

N/A

0.345DataRank · unranked

9 citations

Yanwei Cai, Daeeun Kim, Roelof A. J. Smit, Zhe Wang, Kruthika R. Iyer +169 more

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations

medRxiv(2025)10.1101/2025.02.15.25322341

N/A

0.342DataRank · unranked

4 citations

Yanwei Cai, Daeeun Kim, Roelof A. J. Smit, Zhe Wang, Kruthika Iyer +68 more

Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa

British Journal of Dermatology(2025)10.1093/bjd/ljaf277

N/A

0.330DataRank · unranked

8 citations

Quan Sun, Sharon N. Edmiston, Kevin W. Currin, Swarooparani Vadlamudi, Tyne W. Miller‐Fleming +23 more

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.05.592567

N/A

0.293DataRank · unranked

5 citations

Seyoun Byun, Philip Coryell, Susan D’Costa, Eliza Thulson, HyunAh Kim +11 more

A cross-population compendium of gene–environment interactions

Nature(2026)10.1038/s41586-025-10054-6

Top 56%

0.292DataRank

Top 56%6 citations

Kyuto Sonehara, Yuriko N. Koyanagi, Takezo Kikuchi, Takafumi Ojima, Ryuya Edahiro +39 more

Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health

UNC Libraries(2020)10.17615/xzdq-2960

Top 57%

0.283DataRank

Top 57%2 citations

Karen L. Mohlke, P. Gordon-Larsen, K. M. Harris, Alyssa Richardson, J. Luo +5 more

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits

Genome Research(2025)10.1101/gr.279741.124

N/A

0.283DataRank · unranked

5 citations

Hannah J. Perrin, Gautam Kumar Pandey, Abdalla A Alkhawaja, Swarooparani Vadlamudi, Annie E Musser +14 more

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Digital Commons@Becker (Washington University School of Medicine)(2020)10.17615/g0kx-0208

N/A

0.241DataRank · unranked

4 citations

Tao Huang, Xiaomin Zhang, Xiaobo Yang, Yuan‐Tsong Chen, Young Jin Kim +71 more

Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci

medRxiv(2024)10.1101/2024.06.11.24308730

Top 61%

0.236DataRank

Top 61%3 citations

Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley, Mohammad Yaser Anwar +23 more

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Oxford University Research Archive (ORA) (University of Oxford)(2020)10.17615/gc55-0r45

N/A

0.221DataRank · unranked

2 citations

Sonsoles Morcillo, Nicholas J. Wareham, Richard A. Jensen, Allan Linnenberg, Josée Dupuis +74 more

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries

The Lancet Diabetes & Endocrinology(2026)10.1016/s2213-8587(25)00405-x

N/A

0.208DataRank · unranked

3 citations

Joohyun Kim, Ravi Mandla, Yingchang Lu, Ken Suzuki, Lauren E Petty +255 more

Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data

Diabetes(2025)10.2337/db25-0042

N/A

0.208DataRank · unranked

3 citations

Beena Akolkar, Melina Claussnitzer, Jose C. Florez, Anna L. Gloyn, Struan F.A. Grant +15 more

Genome-wide association study of 1,391 plasma metabolites in 6,136 Finnish men identifies 303 novel signals and provides biological insights into human diseases

medRxiv(2021)10.1101/2021.10.19.21265094

N/A

0.208DataRank · unranked

3 citations

Lap Sum Chan, Debraj Bose, Anne Jackson, Peter VandeHaar, Adam E. Locke +32 more

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

UNC Libraries(2021)10.17615/xzx9-fd89

N/A

0.187DataRank · unranked

1 citations

Michael W. Barnhart, Timo T. Valle, Karen L. Mohlke, Michael Boehnke, Heather M. Stringham +36 more

Genome-wide Association with C-Reactive Protein Levels in CLHNS: Evidence for the CRP and HNF1A Loci and their Interaction with Exposure to a Pathogenic Environment

UNC Libraries(2020)10.17615/2gye-7151

N/A

0.165DataRank · unranked

2 citations

Linda S. Adair, Thomas W. McDade, Ying Wu, Yun Li, Karen L. Mohlke +3 more

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

Nature Aging(2025)10.1038/s43587-025-01006-w

N/A

0.165DataRank · unranked

2 citations

Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He +56 more

Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index

UNC Libraries(2020)10.17615/k3k9-8r50

N/A

0.165DataRank · unranked

2 citations

Ying Wu, Jinxiu Shi, Ethan M. Lange, Jianfeng Xu, Wentao Yuan +13 more

3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk Genes

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.16.492146

N/A

0.154DataRank · unranked

1 citations

Eric S. Davis, Susan D’Costa, Philip Coryell, Nicole E. Kramer, Karen L. Mohlke +4 more

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

UNC Libraries(2020)10.17615/0ngn-wz27

N/A

0.114DataRank · unranked

1 citations

Juliana C.N. Chan, Karen L. Mohlke, Graeme I. Bell, Robin Young, Steven Wiltshire +53 more

Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits

The American Journal of Human Genetics(2025)10.1016/j.ajhg.2025.11.009

N/A

0.104DataRank · unranked

1 citations

Kevin W. Currin, Hannah J. Perrin, Swarooparani Vadlamudi, Amy S. Etheridge, K. Alaine Broadaway +9 more

Trans -ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

Insecta mundi(2020)10.17615/w8m8-6t28

N/A

0.104DataRank · unranked

1 citations

Pasi Soininen, Mete Civelek, Qing Duan, Ying Wu, Markku Laakso +11 more

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

RePEc: Research Papers in Economics(2021)10.17615/ctnf-k559

N/A

0.104DataRank · unranked

1 citations

Nancy J. Cox, T D-GENES, M. Laakso, C. Pihoker, L. Groop +95 more

Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci

International Journal of Obesity(2025)10.1038/s41366-025-01898-z

N/A

0.104DataRank · unranked

1 citations

Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley, Mohammad Yaser Anwar +23 more

TBC1D30 regulates proinsulin and insulin secretion and is the target of a genomic association signal for proinsulin

Diabetologia(2025)10.1007/s00125-025-06391-w

N/A

0.104DataRank · unranked

1 citations

Swarooparani Vadlamudi, Kayleigh M. Voos, Abigail E. Rohy, Anne H. Moxley, Maren E. Cannon +7 more

Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits

The American Journal of Human Genetics(2025)10.1016/j.ajhg.2025.09.003

N/A

0.104DataRank · unranked

1 citations

K. Alaine Broadaway, Victoria A. Parsons, Swarooparani Vadlamudi, Narisu Narisu, Sarah M. Brotman +15 more

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

UNC Libraries(2021)10.17615/j25m-xa12

N/A

0DataRank · unranked

9 citations

Jong‐Young Lee, Shengxu Li, Jyh Ming J.immy Juang, Terri L. Young, Treva Rice +95 more

Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort

UNC Libraries(2021)10.17615/5hgj-vr53

N/A

0DataRank · unranked

5 citations

P. Gordon-Larsen, E.M. Lange, K.M. Harris, A.S. Richardson, Karen L. Mohlke +4 more

A partial loss-of-function variant in AKT2 is associated with reduced insulin-mediated glucose uptake in multiple insulin-sensitive tissues: A genotype-based callback positron emission tomography study

Oxford University Research Archive (ORA) (University of Oxford)(2021)10.17615/djfn-sk41

N/A

0DataRank · unranked

4 citations

Taru Karjalainen, J. Kuusisto, M. Boehnke, L.J. Scott, A. Latva-Rasku +12 more

Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort

UNC Libraries(2021)10.17615/d26b-5j88

N/A

0DataRank · unranked

2 citations

M. Graff, P. Gordon-Larsen, K.M. Harris, Karen L. Mohlke, Leslie A. Lange +4 more

Inferring Regulatory Networks From Mixed Observational Data Using Directed Acyclic Graphs

UNC Libraries(2021)10.17615/awe1-qk20

N/A

0DataRank · unranked

1 citations

Quanpeng Li, Yanwei Li, Daipeng Wu, T.B. Poston, Karen L. Mohlke +5 more

Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study

UNC Libraries(2021)10.17615/s0gj-1r65

N/A

0DataRank · unranked

1 citations

A.S. Richardson, Leslie A. Lange, K.E. North, K.M. Harris, Kristin L. Young +4 more

Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study

UNC Libraries(2020)10.17615/xgey-c257

Top 100%

0DataRank

Top 100%0 citations

Charles B. Eaton, Hyun Min Kang, Logan Dumitrescu, Themistocles L. Assimes, Jeffrey Haessler +27 more

Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults

UNC Libraries(2020)10.17615/73za-5242

N/A

0DataRank · unranked

0 citations

Amanda F. Marvelle, Thomas W. McDade, Yunfei Wang, Damien C. Croteau‐Chonka, Judith B. Borja +9 more

Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels

UNC Libraries(2020)10.17615/ws2p-vq04

N/A

0DataRank · unranked

1 citations

Jin Li, Christopher W. Kuzawa, Alan B. Feranil, Karen L. Mohlke, Linda S. Adair +4 more

Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/vyqs-0e71

N/A

0DataRank · unranked

0 citations

Amy Johnson, Brittney Dietz, Yuanyuan Qin, Melinda A. Beck, Ying Wu +16 more

Multi-SNP mediation intersection-union test

UNC Libraries(2021)10.17615/vtwp-4751

N/A

0DataRank · unranked

0 citations

Xuwei Zheng, Cassandra N. Spracklen, Karen L. Mohlke, Jeremiah Fine, Y. Li +1 more

Content and performance of the MiniMUGA genotyping array: A new tool to improve rigor and reproducibility in mouse research

UNC Libraries(2021)10.17615/tfcg-gt15

N/A

0DataRank · unranked

0 citations

C. Franklin, B.J. Vilen, Lisa M. Tarantino, L. O apos Brien, Ralph S. Baric +64 more

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

UNC Libraries(2021)10.17615/4xxe-xj37

N/A

0DataRank · unranked

0 citations

Samantha Brotman, F.S. Collins, N. Narisu, A.K. Iyengar, A.T. Crain +20 more

Identification of ten loci associated with height highlights new biological pathways in human growth

UNC Libraries(2021)10.17615/jwbr-0w10

N/A

0DataRank · unranked

0 citations

Frank B. Hu, Peter Kraft, S. Eyheramendy, Candace Guiducci, H.‐Erich Wichmann +26 more

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

UNC Libraries(2020)10.17615/4t9n-sj07

N/A

0DataRank · unranked

0 citations

Yonghong Zhang, Yun Kyoung Kim, Wen‐Harn Pan, Woon‐Puay Koh, E. Shyong Tai +95 more

Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

UNC Libraries(2020)10.17615/cygg-8723

N/A

0DataRank · unranked

0 citations

Amanda F. Marvelle, Leslie A. Lange, Sang Lee, Karen L. Mohlke, Linda S. Adair +2 more

Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2022.08.007

N/A

0DataRank · unranked

62 citations

Debraj Bose, Annie Kwon, Sarah C. Hanks, Anne Jackson, Heather M. Stringham +24 more

Genome-wide analysis of copy-number variation in humans with cleft lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as clefting genes

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2022.11.012

N/A

0DataRank · unranked

20 citations

Amanda Dickinson, Sydney Arlis, Huan Liu, Arman Hlas, Alyssa Hahn +15 more

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

UNC Libraries(2020)10.17615/455d-6a15

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Anne Jackson, Mete Civelek, Charles Tilford, Karen L. Mohlke, Calvin Q. Pan +21 more

Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans

UNC Libraries(2020)10.17615/t61g-n927

N/A

0DataRank · unranked

0 citations

Sarah C. Nelson, Adrienne M. Stilp, Robert L. Hanson, Chani J. Hodonsky, Anna Plantinga +33 more

3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes

Genetics(2022)10.1093/genetics/iyac141

N/A

0DataRank · unranked

16 citations

Eric S. Davis, Susan D’Costa, Philip Coryell, Nicole E. Kramer, Karen L. Mohlke +4 more

Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis

Epigenetics(2022)10.1080/15592294.2022.2088145

N/A

0DataRank · unranked

4 citations

Caroline Comenho, David Z. Pan, Marcus Alvarez, Karen L. Mohlke, Markku Laakso +3 more

Pla2g12b is Essential for Expansion of Nascent Lipoprotein Particles

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.02.502564

N/A

0DataRank · unranked

5 citations

Ombretta Foresti, Pradeep Kumar Yadav, Meredith H. Wilson, Tabea Moll, Meng‐Chieh Shen +8 more

A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell

UNC Libraries(2020)10.17615/gfrr-b738

N/A

0DataRank · unranked

0 citations

Christian Fuchsberger, Johanna Kuusisto, Markku Laakso, Michael Boehnke, Michael L. Stitzel +5 more

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

UNC Libraries(2020)10.17615/b3ee-r077

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Mete Civelek, Ying Wu, Marie P. Fogarty, Amanda F. Marvelle +17 more

Fine-Mapping and Initial Characterization of QT Interval Loci in African Americans

UNC Libraries(2020)10.17615/arb6-r827

N/A

0DataRank · unranked

0 citations

Qianchuan He, Nona Sotoodehnia, Megan D. Fesinmeyer, Christopher A. Haiman, D. Y. Lin +17 more

Genetic risk score and adiposity interact to influence triglyceride levels in a cohort of Filipino women

UNC Libraries(2020)10.17615/pskx-g586

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Linda S. Adair, Nida Zubair Zubair, Kari E. North, Elizabeth J. Mayer‐Davis +1 more

Recent advances in understanding the genetic architecture of type 2 diabetes

UNC Libraries(2020)10.17615/w177-8276

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Michael Boehnke

HUGIn: Hi-C Unifying Genomic Interrogator

UNC Libraries(2020)10.17615/mkb6-1p15

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Xu Zheng, Bing Ren, Ming Hu, Joshua S. Martin +3 more

Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

Genome Medicine(2024)10.1186/s13073-024-01291-x

N/A

0DataRank · unranked

30 citations

Marcus Alvarez, Kristina M. Garske, Huiling Huang, Seung Hyuk Lee, Milena Deal +9 more

Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.07.017

N/A

0DataRank · unranked

23 citations

Sarah M. Brotman, Jonathan D. Rosen, Kevin W. Currin, Abdalla A Alkhawaja, Amy S. Etheridge +8 more

Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK

UNC Libraries(2020)10.17615/s8d4-0y68

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Xiao, Rui, Marie P. Fogarty, Laura J. Scott, Ludmila Prokunina‐Olsson

Finding genes and variants for lipid levels after genome-wide association analysis

UNC Libraries(2020)10.17615/1nrs-zs32

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Cristen J. Willer

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

UNC Libraries(2020)10.17615/bd2w-eh24

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Francis S. Collins, Karen L. Mohlke, Alena Stančáková, Päivi Pajukanta, Markku Laakso +4 more

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

UNC Libraries(2020)10.17615/63sx-0c91

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0DataRank · unranked

0 citations

Mark J. Daly, Johanna Kuusisto, Francis S. Collins, Markku Laakso, Kimberly F. Doheny +24 more

Population-specific coding variant underlies genome-wide association with adiponectin level

UNC Libraries(2020)10.17615/yty3-p481

N/A

0DataRank · unranked

0 citations

Leslie A. Lange, Ying Wu, Terry P. Combs, Damien C. Croteau‐Chonka, Marie P. Fogarty +9 more

Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles

UNC Libraries(2020)10.17615/m202-4735

N/A

0DataRank · unranked

0 citations

Swarooparani Vadlamudi, Marie P. Fogarty, Guillaume Lettre, Ken Sin Lo, Karen L. Mohlke

Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci

UNC Libraries(2024)10.17615/pzd2-aw73

N/A

0DataRank · unranked

0 citations

Swarooparani Vadlamudi, K. Alaine Broadaway, Karen L. Mohlke, Kevin W. Currin, Anne H. Moxley +3 more

Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

UNC Libraries(2024)10.17615/c75g-gz70

N/A

0DataRank · unranked

0 citations

Maties Torrent, Struan F.A. Grant, Jonathan A. Mitchell, Joseph M. Kindler, Emily Oken +95 more

Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults

UNC Libraries(2020)10.17615/72ee-y271

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Qin Li, Thomas W. McDade, Leslie A. Lange, Ghenadie Curocichin +5 more

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

Cell Genomics(2025)10.1016/j.xgen.2024.100738

N/A

0DataRank · unranked

19 citations

Seyoun Byun, Philip Coryell, Susan D’Costa, Eliza Thulson, HyunAh Kim +11 more

What Will Diabetes Genomes Tell Us?

UNC Libraries(2020)10.17615/5bv7-zf46

N/A

0DataRank · unranked

0 citations

Laura J. Scott, Karen L. Mohlke

Association Studies with Imputed Variants Using Expectation-Maximization Likelihood-Ratio Tests

UNC Libraries(2020)10.17615/takt-vv35

N/A

0DataRank · unranked

0 citations

Karen L. Mohlke, Wei Sun, Mengjie Chen, Leslie A. Lange, Yun Li +2 more

Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses

UNC Libraries(2020)10.17615/d2rw-pb90

N/A

0DataRank · unranked

0 citations

Matthew R. Schaner, Mark J. Koruda, Dermot McGovern, Matthew Weiser, Karen L. Mohlke +11 more

Quantifying prion disease penetrance using large population control cohorts

UNC Libraries(2020)10.17615/m8r0-g416

N/A

0DataRank · unranked

1 citations

Hidehiro Mizusawa, Pamela Sklar, Nobuo Sanjo, Miguel Calero, Theo F. J. Kraus +58 more

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

UNC Libraries(2020)10.17615/aw16-yw40

N/A

0DataRank · unranked

0 citations

Claudia Langenberg, Majken K. Jensen, Louis T. Pasquale, Camilla H. Sandholt, Robert W. Koivula +27 more

INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

UNC Libraries(2020)10.17615/bdbx-cj52

N/A

0DataRank · unranked

11 citations

Karen L. Mohlke, Chad Torrice, Christin E. Burd, Norman E. Sharpless, Hanna K. Sanoff +4 more

Replication of LIN28B SNP association with age of menarche in young Filipino women: LIN28Bassociation with age of menarche

UNC Libraries(2020)10.17615/fj4d-fb90

N/A

0DataRank · unranked

0 citations

D. C. Croteau‐Chonka, Karen L. Mohlke, Leslie A. Lange, L. S. Adair, N. R. Lee

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

medRxiv(2020)10.1101/2020.09.22.20195529

N/A

0DataRank · unranked

11 citations

Moriel Singer‐Berk, Rachel G. Son, Abigail Sveden, Jordan C. Wood, Eleina England +95 more

Higher eQTL power reveals signals that boost GWAS colocalization

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.05.668745

N/A

0DataRank · unranked

3 citations

K. Alaine Broadaway, Sarah M. Brotman, Karen L. Mohlke, Michael I. Love, Jonathan D. Rosen

Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits

UNC Libraries(2025)10.17615/84d2-8s94

N/A

0DataRank · unranked

0 citations

Federico Innocenti, Paul J. Gallins, Jonathan D. Rosen, Michael I. Love, Kevin W. Currin +8 more

Inferring Regulatory Networks From Mixed Observational Data Using Directed Acyclic Graphs

Frontiers in Genetics(2020)10.3389/fgene.2020.00008

N/A

0DataRank · unranked

17 citations

Dong Li, Taylor B. Poston, Toni Darville, Cassandra N. Spracklen, Di Wu +5 more

Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell typae abundance and fiber-type-level gene expression

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.27.683567

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Sarah C. Hanks, Arushi Varshney, Michael R. Erdos, Nandini Manickam, Heather M. Stringham +16 more

Association of metabolomics measurements with blood cell phenotypes

Blood Cells Molecules and Diseases(2025)10.1016/j.bcmd.2025.102966

N/A

0DataRank · unranked

0 citations

Amanda L. Tapia, Eric Boerwinkle, Clary B. Clish, Robert E. Gerszten, Misa Graff +15 more

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

UNC Libraries(2025)10.17615/x77k-dc42

N/A

0DataRank · unranked

0 citations

Seyoun Byun, Michael I. Love, Emma R. Klein, Nicole E. Kramer, Brian O. Diekman +11 more

Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits

UNC Libraries(2025)10.17615/nsv1-m508

N/A

0DataRank · unranked

0 citations

Anniina Oravilahti, Morgan N. Narain, Jonathan D. Rosen, Michael I. Love, Marcus Alvarez +17 more

Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

UNC Libraries(2025)10.17615/n93c-4612

N/A

0DataRank · unranked

0 citations

Markku Laakso, Milena Deal, Amogha Koka, Kristina M. Garske, Seung Hyuk Lee +9 more

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits

UNC Libraries(2025)10.17615/vj0s-7k07

N/A

0DataRank · unranked

0 citations

Chelsea K. Raulerson, Kerrin S. Small, Julia S. El-Sayed Moustafa, Sarah M. Brotman, Laura J. Scott +29 more

Identification of a Regulatory Variant That Binds FOXA1 and FOXA2 at the CDC123/CAMK1D Type 2 Diabetes GWAS Locus

UNC Libraries(2020)10.17615/3q6g-hp04

N/A

0DataRank · unranked

0 citations

Kyle J. Gaulton, Maren E. Cannon, Swarooparani Vadlamudi, Marie P. Fogarty, Karen L. Mohlke

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Genome Medicine(2021)10.1186/s13073-021-00939-2

N/A

0DataRank · unranked

46 citations

Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk Lee +16 more

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

PLoS Genetics(2021)10.1371/journal.pgen.1009865

N/A

0DataRank · unranked

33 citations

Kevin W. Currin, Swarooparani Vadlamudi, Gautam Kumar Pandey, Kenneth K.H. Ng, Martin Wabitsch +4 more

Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 GeneHighlights

UNC Libraries(2020)10.17615/3y7x-9f70

N/A

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0 citations

Yash Bhagat, Carlos A. Aguilar‐Salinas, Alejandra Rodríguez, Arthur Ko, Karen L. Mohlke +12 more

Karen L. Mohlke

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